Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The emerging role of lysophosphatidic acid in cancer

2003 • 1,086 citations

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 458 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2

2004 • 350 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

2000 • 276 citations

Implications for the Catalytic Mechanism of the Vanadium-Containing Enzyme Chloroperoxidase from the Fungus Curvularia inaequalis by X-Ray Structures of the Native and Peroxide Form

1997 • 275 citations

Mammalian Lipid Phosphate Phosphohydrolases

1998 • 253 citations

2-Arachidonoylglycerol and the cannabinoid receptors

2000 • 225 citations

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.

2003 • 223 citations

Ceramide Kinase Mediates Cytokine- and Calcium Ionophore-induced Arachidonic Acid Release

2003 • 213 citations

The Drosophila protein Wunen repels migrating germ cells

1997 • 205 citations

Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation

2004 • 202 citations

Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages

2004 • 201 citations

Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions

1997 • 200 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

Molecular mechanisms of lysophosphatidic acid action

2003 • 181 citations

Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2

2003 • 172 citations

The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning

2003 • 166 citations

Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells

2001 • 161 citations

Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability

2003 • 161 citations

Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

1997 • 157 citations

The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.

2003 • 142 citations

Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters

1999 • 141 citations

Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1

2003 • 136 citations

Lysophosphatidic Acid-induced Mitogenesis Is Regulated by Lipid Phosphate Phosphatases and Is Edg-receptor Independent

2001 • 136 citations

A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting

2003 • 133 citations

Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction

1999 • 131 citations

Lipid Metabolism and Regulation of Membrane Trafficking

2000 • 126 citations

Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids

2002 • 119 citations

Sequential Actions of Phospholipase D and Phosphatidic Acid Phosphohydrolase 2b Generate Diglyceride in Mammalian Cells

1999 • 116 citations

Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action

2000 • 110 citations

Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes

1996 • 109 citations

G-protein-coupled Receptor Stimulation of the p42/p44 Mitogen-activated Protein Kinase Pathway Is Attenuated by Lipid Phosphate Phosphatases 1, 1a, and 2 in Human Embryonic Kidney 293 Cells

2001 • 94 citations

Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids

2002 • 90 citations

Sphingosine‐1‐phosphate modulates growth and adhesion of ovarian cancer cells

1999 • 87 citations

Tight Binding Inhibition of Protein Phosphatase-1 by Phosphatidic Acid

2002 • 83 citations

Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets

2003 • 83 citations

Lipid mediators of angiogenesis and the signalling pathways they initiate

2002 • 72 citations

The Dri 42 Gene, Whose Expression Is Up-regulated during Epithelial Differentiation, Encodes a Novel Endoplasmic Reticulum Resident Transmembrane Protein

1996 • 71 citations

Mice mutant forPpap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile

2000 • 71 citations

Involvement of Phospholipase D2 in Lysophosphatidate-induced Transactivation of Platelet-derived Growth Factor Receptor-β in Human Bronchial Epithelial Cells

2003 • 68 citations

Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP

2003 • 66 citations

Inhibition of cell adhesion to glycoproteins of the extracellular matrix by peptides corresponding to serum amyloid A

1994 • 66 citations

Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level

2003 • 65 citations

Molecular cloning and expression regulation of PRG‐3, a new member of the plasticity‐related gene family

2003 • 65 citations

Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo

2003 • 55 citations

Molecular Cloning of Two Alternatively Spliced Forms of Human Phosphatidic Acid Phosphatase cDNAs that Are Differentially Expressed in Normal and Tumor Cells

1998 • 52 citations

Histidine 167 Is the Phosphate Acceptor in Glucose-6-phosphatase-β Forming a Phosphohistidine Enzyme Intermediate during Catalysis

2004 • 51 citations

A Gonadotropin-Releasing Hormone-Responsive Phosphatase Hydrolyses Lysophosphatidic Acid within the Plasma Membrane of Ovarian Cancer Cells

2000 • 50 citations

Identification of the Phosphatidic Acid Phosphatase Type 2a Isozyme as an Androgen-regulated Gene in the Human Prostatic Adenocarcinoma Cell Line LNCaP

1998 • 48 citations

Pulmonary lipid phosphate phosphohydrolase in plasma membrane signalling platforms

2001 • 45 citations

Expression of Ectolipid Phosphate Phosphohydrolases in 3T3F442A Preadipocytes and Adipocytes

2002 • 43 citations

Isolation of a cDNA Encoding Human Lysophosphatidic Acid Phosphatase That Is Involved in the Regulation of Mitochondrial Lipid Biosynthesis

1999 • 42 citations

Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators

2000 • 41 citations

Transmembrane topology of sphingoid long‐chain base‐1‐phosphate phosphatase, Lcb3p

2003 • 38 citations

Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells

2003 • 37 citations

Regulation of Cyclooxygenase-2 Expression by Phosphatidate Phosphohydrolase in Human Amnionic WISH Cells

1999 • 35 citations

Regulation of Phosphatidic Acid Phosphohydrolase by Epidermal Growth Factor

1996 • 29 citations

Injury-elicited differential transcriptional regulation of phospholipid growth factor receptors in the cornea

2002 • 28 citations

Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity.

2004 • 26 citations

Lipid phosphate phosphatase-1 dephosphorylates exogenous lysophosphatidate and thereby attenuates its effects on cell signalling

2001 • 22 citations

Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin‒Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor

2002 • 18 citations

A Gonadotropin-Releasing Hormone-Responsive Phosphatase Hydrolyses Lysophosphatidic Acid within the Plasma Membrane of Ovarian Cancer Cells

2000 • 17 citations

Cholecystokinin expression after hippocampal deafferentiation: molecular evidence revealed by differential display-reverse transcription–polymerase chain reaction

2003 • 11 citations

A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting

2003 • 5 citations