The sphingosine 1‐phosphate receptor S1P₄ regulates cell shape and motility via coupling to G_i and G_12/13

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

1999 • 412 citations

Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins

1999 • 329 citations

Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3

2000 • 328 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Comparison of Intrinsic Activities of the Putative Sphingosine 1-Phosphate Receptor Subtypes to Regulate Several Signaling Pathways in Their cDNA-transfected Chinese Hamster Ovary Cells

1999 • 219 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association with Suppression of Bax

1999 • 219 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Ligand-induced Trafficking of the Sphingosine-1-phosphate Receptor EDG-1

1999 • 180 citations

G protein-coupled receptor adaptation mechanisms

1998 • 177 citations

EDG3 Is a Functional Receptor Specific for Sphingosine 1-Phosphate and Sphingosylphosphorylcholine with Signaling Characteristics Distinct from EDG1 and AGR16

1999 • 176 citations

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

2000 • 174 citations

Recombinant Human G Protein-Coupled Lysophosphatidic Acid Receptors Mediate Intracellular Calcium Mobilization

1998 • 163 citations

Gonadotropin-releasing Hormone Receptor Initiates Multiple Signaling Pathways by Exclusively Coupling to Gq/11Proteins

2000 • 162 citations

Edg-6 as a Putative Sphingosine 1-Phosphate Receptor Coupling to Ca2+ Signaling Pathway

2000 • 154 citations

A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs)

1999 • 153 citations

Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate

2002 • 129 citations

Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors.

1999 • 123 citations

Urokinase Stimulates Human Vascular Smooth Muscle Cell Migration via a Phosphatidylinositol 3-Kinase-Tyk2 Interaction

2000 • 77 citations

The Mouse Gene for the Inducible G-Protein-Coupled Receptoredg-1

1997 • 75 citations

N‐Glycans of sphingosine 1‐phosphate receptor Edg‐1 regulate ligand‐induced receptor internalization

2002 • 71 citations

[25] Identification of receptor-activated G proteins with photoreactive GTP analog, [α-32P]GTP azidoanilide

1991 • 70 citations

Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles.

1998 • 63 citations

Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1‐phosphate

2000 • 61 citations

Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles.

1998 • 56 citations

[22] Identification of receptor-activated G proteins: Selective immunoprecipitation of photolabeled G-protein α subunits

1994 • 55 citations

Activation of phospholipase C‐Ca²⁺ system by sphingosine 1‐phosphate in CHO cells transfected with Edg‐3, a putative lipid receptor

1999 • 55 citations

Embryonic expression pattern of H218, a G-protein coupled receptor homolog, suggests roles in early mammalian nervous system development

1997 • 35 citations

Activation of Gi1by Lysophosphatidic Acid Receptor without Ligand in the Baculovirus Expression System

1999 • 28 citations

A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids

1999 • 28 citations

Topological Characterization of the Lymphoid-Specific Seven Transmembrane Receptor BLR1 by Epitope Tagging and High Level Expression

1993 • 15 citations

Tandem genomic arrangement of a G protein (Gna15) and G protein‐coupled receptor (s1p₄/lp_C1/Edg6) gene

2002 • 15 citations