Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.

1992 • 577 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine

1998 • 420 citations

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

1999 • 412 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

Nucleotide Pyrophosphatases/Phosphodiesterases on the Move

2000 • 283 citations

A single receptor encoded by vzg-1 / lp _A1 / edg- 2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1998 • 280 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Characterization of plasma unsaturated lysophosphatidylcholines in human and rat

1999 • 233 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.

1994 • 202 citations

Induction of in Vitro Tumor Cell Invasion of Cellular Monolayers by Lysophosphatidic Acid or Phospholipase D

1993 • 185 citations

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

1989 • 185 citations

Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)

1999 • 169 citations

Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma

1986 • 165 citations

Autotaxin Is an Exoenzyme Possessing 5′-Nucleotide Phosphodiesterase/ATP Pyrophosphatase and ATPase Activities

1997 • 159 citations

Elevated levels and altered fatty acid composition of plasma lysophosphatidlycholine(lysoPC) in ovarian cancer patients

1997 • 148 citations

Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid

1999 • 119 citations

Phorbol 12-Myristate 13-Acetate Stimulates Lysophosphatidic Acid Secretion from Ovarian and Cervical Cancer Cells but Not from Breast or Leukemia Cells

1998 • 113 citations

Role of lysophosphatidic acid and Rho in glioma cell motility

2000 • 104 citations

Enzymatic Determination of Phospholipase D Activity with Choline Oxidase

1978 • 92 citations

Stimulation of Tumor Cell Motility Linked to Phosphodiesterase Catalytic Site of Autotaxin

1996 • 91 citations

Autotaxin, tumor motility-stimulating exophosphodiesterase

1997 • 90 citations

New water-soluble hydrogen donors for the enzymatic spectrophotometric determination of hydrogen peroxide

1982 • 88 citations

Exogenous phospholipase D generates Iysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways

1998 • 84 citations

New water-soluble hydrogen donors for the enzymatic photometric determination of hydrogen peroxide. II. N-ethyl-N-(2-hydroxy-3-sulfopropyl)aniline derivatives.

1982 • 81 citations

Increased formation of lysophosphatidic acids by lysophospholipase D in serum of hypercholesterolemic rabbits

2002 • 50 citations

Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats

1999 • 40 citations

Lysophosphatidic Acids Produced by Lysophospholipase D in Mammalian Serum and Body Fluid

2000 • 34 citations

Cell Cycle-dependent Interaction of Mad2 with Conserved Box1/2 Region of Human Granulocyte-Macrophage Colony-stimulating Factor Receptor Common βc

2001 • 9 citations