Sphingosine kinase: a mediator of vital cellular functions

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

A vital role for glycosphingolipid synthesis during development and differentiation

1999 • 482 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction

1997 • 354 citations

Involvement of Yeast Sphingolipids in the Heat Stress Response of Saccharomyces cerevisiae

1997 • 294 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response

1998 • 244 citations

Cell regulation by sphingosine and more complex sphingolipids

1991 • 242 citations

Sphingolipids Are Potential Heat Stress Signals inSaccharomyces

1997 • 242 citations

High Density Lipoproteins (HDL) Interrupt the Sphingosine Kinase Signaling Pathway

1999 • 235 citations

The BST1 Gene of Saccharomyces cerevisiaeIs the Sphingosine-1-phosphate Lyase

1997 • 235 citations

Sphingolipid metabolites: Members of a new class of lipid second messengers

1995 • 226 citations

Purification and Characterization of Rat Kidney Sphingosine Kinase

1998 • 221 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association with Suppression of Bax

1999 • 219 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

Functions of a new family of sphingosine-1-phosphate receptors

2000 • 194 citations

The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases

1998 • 184 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Sphingosine 1-phosphate: a prototype of a new class of second messengers

1999 • 176 citations

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

1999 • 175 citations

FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking

1998 • 172 citations

Identification of the First Mammalian Sphingosine Phosphate Lyase Gene and Its Functional Expression in Yeast

1998 • 168 citations

Discussion

1999 • 154 citations

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase

1997 • 154 citations

Bimodal Regulation of Ceramidase by Interleukin-1β

1997 • 152 citations

Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells

1992 • 144 citations

Analysis of Phosphorylated Sphingolipid Long-Chain Bases Reveals Potential Roles in Heat Stress and Growth Control in Saccharomyces

1999 • 133 citations

Calcium Release-activated Calcium Current (I CRAC) Is a Direct Target for Sphingosine

1998 • 113 citations

1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.

1998 • 107 citations

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades

1996 • 106 citations

Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selection

1992 • 100 citations

Formyl Peptide Receptor Signaling in HL-60 Cells through Sphingosine Kinase

1999 • 99 citations

Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors

1997 • 99 citations

De Novo Synthesis of Sphingolipids Is Required for Cell Survival by Down-Regulating c-Jun N-Terminal Kinase in Drosophila Imaginal Discs

1999 • 96 citations

Identification of a Saccharomyces Gene,LCB3, Necessary for Incorporation of Exogenous Long Chain Bases into Sphingolipids

1997 • 93 citations

Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells

2000 • 89 citations

Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.

1999 • 87 citations

Regulatory Effect of Phorbol Esters on Sphingosine Kinase in BALB/C 3T3 Fibroblasts (Variant A31): Demonstration of Cell Type-Specific Response - A Preliminary Note

1994 • 87 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity

1996 • 78 citations

Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ

1999 • 77 citations

TheDPL1Gene Is Involved in Mediating the Response to Nutrient Deprivation inSaccharomyces cerevisiae

1999 • 70 citations

Role of sphingosine kinase in Ca²⁺ signalling by epidermal growth factor receptor

1999 • 70 citations

Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants

1998 • 62 citations

Sphingosine Kinase Mediates Cyclic AMP Suppression of Apoptosis in Rat Periosteal Cells

1998 • 55 citations

Evidence for the presence of multiple forms of Sph kinase in human platelets

1998 • 54 citations

Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate—caged SPP

1998 • 41 citations

Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation

1999 • 38 citations

Cell cycle control of PDGF‐induced Ca²⁺signaling through modulation of sphingolipid metabolism

1999 • 20 citations

Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation

1999 • 16 citations

Sphingosine 1-phosphate

2003 • 6 citations

[Biosynthesis of sphingolipids].

2002 • 3 citations