Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Quantitative analysis of phospholipids by thin-layer chromatography

1964 • 1,414 citations

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

2002 • 527 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors

2002 • 309 citations

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

2002 • 305 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association with Suppression of Bax

1999 • 219 citations

Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide Production

2001 • 201 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.

1989 • 192 citations

Sphingosine‐1‐phosphate: dual messenger functions

2002 • 188 citations

Identification of the First Mammalian Sphingosine Phosphate Lyase Gene and Its Functional Expression in Yeast

1998 • 168 citations

TNF-α-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes

2001 • 163 citations

Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability

2003 • 161 citations

Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma.

1991 • 154 citations

Chromosomal alterations in the clonal evolution to the metastatic stage of squamous cell carcinomas of the lung

2000 • 146 citations

Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades

1998 • 145 citations

Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver

1991 • 142 citations

Analysis of Phosphorylated Sphingolipid Long-Chain Bases Reveals Potential Roles in Heat Stress and Growth Control in Saccharomyces

1999 • 133 citations

Sphingosine 1-phosphate as a therapeutic agent

2002 • 124 citations

Splyregulation of sphingolipid signaling molecules is essential for Drosophila development

2003 • 114 citations

BcR-induced Apoptosis Involves Differential Regulation of C16 and C24-Ceramide Formation and Sphingolipid-dependent Activation of the Proteasome

2003 • 111 citations

Sphingosine-1-phosphate and lipid phosphohydrolases

2002 • 109 citations

Analysis of Sphingomyelin, Glucosylceramide, Ceramide, Sphingosine, and Sphingosine 1-Phosphate by Tandem Mass Spectrometry

2000 • 108 citations

Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q2211DNA sequence was deposited in the EMBL database (AJ011304).

2000 • 108 citations

Sphingosine-1-Phosphate Phosphatases

2001 • 101 citations

[28] Sphingosine-1-phosphate lyase

2000 • 97 citations

Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinoma

1990 • 97 citations

Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases.

1990 • 96 citations

Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility

2002 • 95 citations

Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation

2001 • 94 citations

Analysis of natural and synthetic sphingomyelins using high‐performance thin‐layer chromatography

1999 • 88 citations

Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors

2002 • 87 citations

Two tumor suppressive loci on chromosome 10 involved in human glioblastomas

1995 • 86 citations

cis-4-Methylsphingosine Decreases Sphingolipid Biosynthesis by Specifically Interfering with Serine Palmitoyltransferase Activity in Primary Cultured Neurons

1997 • 76 citations

Sphingosine-1-phosphate Lyase Is Involved in the Differentiation of F9 Embryonal Carcinoma Cells to Primitive Endoderm

2003 • 75 citations

Allelic loss on chromosome 10q in human lung cancer: association with tumour progression and metastatic phenotype

1998 • 72 citations

TheDPL1Gene Is Involved in Mediating the Response to Nutrient Deprivation inSaccharomyces cerevisiae

1999 • 70 citations

Chromosomal Imbalances in Brain Metastases of Solid Tumors

2000 • 68 citations

Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum

2001 • 67 citations

Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans

2003 • 65 citations

Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria

2003 • 53 citations

Genetic imbalances in 67 synovial sarcomas evaluated by comparative genomic hybridization

1998 • 46 citations

Microsatellite instability and deletion analysis of chromosome 10 in human prostate cancer

1996 • 41 citations

Asnc1Endocytosis Mutant: Phenotypic Analysis and Suppression by Overproduction of Dihydrosphingosine Phosphate Lyase

2000 • 41 citations

Oxidative cleavage of lipids with sodium metaperiodate in pyridine

1969 • 38 citations

Molecular Cytogenetic Analysis of 17 Renal Cancer Cell Lines: Increased Copy Number at 5q31‐33 in Cell Lines from Nonpapillary Carcinomas

2000 • 31 citations

Molecular and cytogenetic characterization of a t(1;10;21) translocation in the human papillary thyroid cancer cell line TPC-1 expressing the ret/H4 chimeric transcript

1995 • 30 citations

Sphingolipid metabolism and cell signaling

2000 • 29 citations

Molecular analysis of a myxoid chondrosarcoma with rearrangements of chromosomes 10 and 22

1990 • 25 citations

Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies

2006 • 23 citations

Deletionen des Chromosoms 10q - Marker für die Metastasierung bei Kopf-Hals-Karzinomen?

2000 • 7 citations