Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

2002 • 723 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.

1992 • 577 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways

2002 • 413 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Sphingosine 1-Phosphate Induces Angiogenesis: Its Angiogenic Action and Signaling Mechanism in Human Umbilical Vein Endothelial Cells

1999 • 359 citations

Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3

2000 • 328 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood

2002 • 254 citations

Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

2001 • 245 citations

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

2001 • 242 citations

Electrospray Ionization Mass Spectrometry Analysis of Lysophospholipids in Human Ascitic Fluids: Comparison of the Lysophospholipid Contents in Malignant vs Nonmalignant Ascitic Fluids

2001 • 234 citations

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

1992 • 223 citations

Sphingosine-1-Phosphate, a Platelet-Derived Lysophospholipid Mediator, Negatively Regulates Cellular Rac Activity and Cell Migration in Vascular Smooth Muscle Cells

2002 • 219 citations

cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.

1994 • 202 citations

Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor.

2001 • 194 citations

Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist

2002 • 191 citations

Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells

2000 • 188 citations

Induction of in Vitro Tumor Cell Invasion of Cellular Monolayers by Lysophosphatidic Acid or Phospholipase D

1993 • 185 citations

Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors

2002 • 172 citations

Induction of Endothelial Cell Chemotaxis by Sphingosine 1-Phosphate and Stabilization of Endothelial Monolayer Barrier Function by Lysophosphatidic Acid, Potential Mediators of Hematopoietic Angiogenesis

1999 • 159 citations

Autotaxin Is an Exoenzyme Possessing 5′-Nucleotide Phosphodiesterase/ATP Pyrophosphatase and ATPase Activities

1997 • 159 citations

Ecto‐phosphodiesterase/pyrophosphatase of lymphocytes and non‐lymphoid cells: structure and function of the PC‐1 family

1998 • 152 citations

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

2001 • 142 citations

Sphingosylphosphorylcholine—biological functions and mechanisms of action

2002 • 132 citations

Phosphodiesterase I, A Novel Adhesion Molecule and/or Cytokine Involved in Oligodendrocyte Function

1997 • 107 citations

Sphingosine-1-Phosphate and Lysophosphatidic Acid Stimulate Endothelial Cell Migration

2000 • 103 citations

Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane

2001 • 96 citations

Enzymatic Determination of Phospholipase D Activity with Choline Oxidase

1978 • 92 citations

Stimulation of Tumor Cell Motility Linked to Phosphodiesterase Catalytic Site of Autotaxin

1996 • 91 citations

Integrin αvβ3 Mediates Chemotactic and Haptotactic Motility in Human Melanoma Cells through Different Signaling Pathways

1996 • 91 citations

New water-soluble hydrogen donors for the enzymatic spectrophotometric determination of hydrogen peroxide

1982 • 88 citations

Developmental expression analysis of murine autotaxin (ATX)

1999 • 88 citations

Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.

1999 • 87 citations

Inhibition of chemotactic motility and trans‐endothelial migration of human neutrophils by sphingosine 1‐phosphate

1997 • 83 citations

Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers

2000 • 66 citations

Migration of Vascular Smooth Muscle Cells Induced by Sphingosine 1-Phosphate and Related Lipids: Potential Role in the Angiogenic Response

2002 • 65 citations

Dual Regulation of Actin Rearrangement through Lysophosphatidic Acid Receptor in Neuroblast Cell Lines: Actin Depolymerization by Ca²⁺-α-Actinin and Polymerization by Rho

2002 • 61 citations

Site-directed mutations in the tumor-associated cytokine, autotaxin, eliminate nucleotide phosphodiesterase, lysophospholipase D, and motogenic activities.

2003 • 52 citations

Differential regulation of the expression of nucleotide pyrophosphatases/phosphodiesterases in rat liver

1999 • 49 citations

Sphingosine‐1‐phosphate Inhibits Haptotactic Motility by Overproduction of Focal Adhesion Sites in B16 Melanoma Cells through EDG‐Induced Activation of Rho

2000 • 30 citations

A sensitive screening assay for secreted motility-stimulating factors

2000 • 18 citations