Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

2001 • 1,012 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

Phosphatidic acid, a key intermediate in lipid metabolism

1999 • 379 citations

Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway

1999 • 297 citations

Mammalian Lipid Phosphate Phosphohydrolases

1998 • 253 citations

Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic Acid

2004 • 205 citations

Human Type 2 Phosphatidic Acid Phosphohydrolases

1998 • 178 citations

The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning

2003 • 166 citations

Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

1997 • 157 citations

Tethering of the Platelet-derived Growth Factor β Receptor to G-protein-coupled Receptors

2001 • 153 citations

The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.

2003 • 142 citations

Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters

1999 • 141 citations

Lysophosphatidic Acid-induced Mitogenesis Is Regulated by Lipid Phosphate Phosphatases and Is Edg-receptor Independent

2001 • 136 citations

A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting

2003 • 133 citations

A Novel Sphingosine-dependent Protein Kinase (SDK1) Specifically Phosphorylates Certain Isoforms of 14-3-3 Protein

1998 • 130 citations

Identification of a Phosphothionate Analogue of Lysophosphatidic Acid (LPA) as a Selective Agonist of the LPA3 Receptor

2003 • 121 citations

Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids

2002 • 119 citations

Sequential Actions of Phospholipase D and Phosphatidic Acid Phosphohydrolase 2b Generate Diglyceride in Mammalian Cells

1999 • 116 citations

Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action

2000 • 110 citations

Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes

1996 • 109 citations

Photolysis of intracellular caged sphingosine‐1‐phosphate causes Ca²⁺ mobilization independently of G‐protein‐coupled receptors

2003 • 97 citations

G-protein-coupled Receptor Stimulation of the p42/p44 Mitogen-activated Protein Kinase Pathway Is Attenuated by Lipid Phosphate Phosphatases 1, 1a, and 2 in Human Embryonic Kidney 293 Cells

2001 • 94 citations

Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets

2003 • 83 citations

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells

2005 • 75 citations

The Dri 42 Gene, Whose Expression Is Up-regulated during Epithelial Differentiation, Encodes a Novel Endoplasmic Reticulum Resident Transmembrane Protein

1996 • 71 citations

Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level

2003 • 65 citations

Enantioselective Responses to a Phosphorothioate Analogue of Lysophosphatidic Acid with LPA₃Receptor-Selective Agonist Activity

2003 • 58 citations

Geldanamycin decreases Raf‐1 and Akt levels and induces apoptosis in neuroblastomas

2002 • 55 citations

Molecular Cloning of Two Alternatively Spliced Forms of Human Phosphatidic Acid Phosphatase cDNAs that Are Differentially Expressed in Normal and Tumor Cells

1998 • 52 citations

Pulmonary lipid phosphate phosphohydrolase in plasma membrane signalling platforms

2001 • 45 citations

Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle

1997 • 40 citations

Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells

2003 • 37 citations

Cell Surface Activities of the Human Type 2b Phosphatidic Acid Phosphatase

2000 • 29 citations

Pulmonary lipid phosphate phosphohydrolase in plasma membrane signalling platforms

2001 • 28 citations

Concerted action of cytosolic Ca2+ and protein kinase C in receptor-mediated phospholipase D activation in Chinese hamster ovary cells expressing the cholecystokinin-A receptor

1999 • 19 citations

Molecular Cloning of Magnesium-Independent Type 2 Phosphatidic Acid Phosphatases from Airway Smooth Muscle

1999 • 16 citations

Interaction of caspase‐3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

2003 • 12 citations