Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

2002 • 462 citations

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation

2003 • 373 citations

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory

2000 • 364 citations

Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3

2000 • 328 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

First Human Trial of FTY720, a Novel Immunomodulator, in Stable Renal Transplant Patients

2002 • 272 citations

Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3

2001 • 271 citations

Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5

1999 • 255 citations

Activation‐regulated expression and chemotactic function of sphingosine 1‐phosphate receptors in mouse splenic T cells

2002 • 229 citations

Lysophospholipid receptor nomenclature

2002 • 225 citations

Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols

2000 • 214 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

FTY720: ALTERED LYMPHOCYTE TRAFFIC RESULTS IN ALLOGRAFT PROTECTION

2001 • 175 citations

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

2001 • 142 citations

Cell Type-specific Localization of Human Cardiac S1P Receptors

2002 • 120 citations

Sphingosine 1-phosphate and control of vascular tone

2003 • 119 citations

Sphingosine-1-Phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4+ T Cells

2003 • 119 citations

S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate

2003 • 119 citations

Activation of muscarinic K+ current in guinea‐pig atrial myocytes by sphingosine‐1‐phosphate.

1995 • 106 citations

Sphingosine‐1‐phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro

2000 • 103 citations

Sphingosine 1-Phosphate Contracts Canine Basilar Arteries In Vitro and In Vivo

2001 • 100 citations

Transduction of Multiple Effects of Sphingosine 1-Phosphate (S1P) on T Cell Functions by the S1P1 G Protein-Coupled Receptor

2003 • 99 citations

EDG1 Receptor Stimulation Leads to Cardiac Hypertrophy in Rat Neonatal Myocytes

2001 • 96 citations

Evidence for Edg-3 Receptor-Mediated Activation ofI_K.ACh by Sphingosine-1-Phosphate in Human Atrial Cardiomyocytes

2000 • 85 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 81 citations

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

2000 • 73 citations

Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells

1999 • 70 citations

Expression and characterization of Edg‐1 receptors in rat cardiomyocytes

2000 • 46 citations

Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System

2000 • 30 citations

Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells

1999 • 28 citations

A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids

1999 • 28 citations

Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat

2002 • 28 citations

A New Efficient Synthesis of the Immunosuppressive Agent FTY-720

2000 • 25 citations

Comparative analysis of human and rat S1P5 (edg8): differential expression profiles and sensitivities to antagonists

2002 • 23 citations