The role of sphingosine-1-phosphate in smooth muscle contraction

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Ca²⁺Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase

2003 • 1,913 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

2000 • 664 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 611 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 578 citations

Nitric Oxide and Cardiac Function

2003 • 554 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

2002 • 527 citations

Increased mast cells in the irritable bowel syndrome

2000 • 481 citations

SMOOTH MUSCLE CONTRACTION AND RELAXATION

2003 • 452 citations

Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum

1997 • 442 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

2003 • 427 citations

Critical role of mast cells in inflammatory diseases and the effect of acute stress

2003 • 426 citations

Cofilin Phosphorylation and Actin Cytoskeletal Dynamics Regulated by Rho- and Cdc42-Activated Lim-Kinase 2

1999 • 384 citations

Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility

2000 • 336 citations

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

2004 • 329 citations

Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3

2000 • 328 citations

Lysophospholipid Receptors

2001 • 319 citations

Transactivation of Sphingosine-1–Phosphate Receptors by FcεRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

2004 • 313 citations

New Developments in Phospholipase D

1997 • 313 citations

Specific Activation of LIM kinase 2 via Phosphorylation of Threonine 505 by ROCK, a Rho-dependent Protein Kinase

2001 • 310 citations

Serine Phosphorylation Negatively Regulates RhoA in Vivo

2003 • 307 citations

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2

2003 • 300 citations

Ca ²⁺ -Dependent Activation of Rho and Rho Kinase in Membrane Depolarization–Induced and Receptor Stimulation–Induced Vascular Smooth Muscle Contraction

2003 • 285 citations

Lysophospholipid G Protein-coupled Receptors

2004 • 281 citations

Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3

2001 • 271 citations

Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5

1999 • 255 citations

Ca2+-independent Smooth Muscle Contraction

2001 • 252 citations

The developing relationship between receptor‐operated and store‐operated calcium channels in smooth muscle

2002 • 252 citations

Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3

2002 • 241 citations

Invited Review: Mechanisms of calcium handling in smooth muscles

2001 • 239 citations

Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells.

1991 • 226 citations

Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor

1996 • 213 citations

Identification of the endogenous smooth muscle myosin phosphatase-associated kinase

2001 • 207 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

An essential role for the H218/AGR16/Edg‐5/LP_B2 sphingosine 1‐phosphate receptor in neuronal excitability

2001 • 182 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors

2000 • 172 citations

Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase

2002 • 165 citations

Agonist-modulated Targeting of the EDG-1 Receptor to Plasmalemmal Caveolae

2000 • 159 citations

Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate

2002 • 154 citations

Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase

2003 • 142 citations

Sphingosine 1-Phosphate and Isoform-specific Activation of Phosphoinositide 3-Kinase β

2001 • 132 citations

Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate

2002 • 129 citations

Comparison of Sphingosine 1-Phosphate–Induced Intracellular Signaling Pathways in Vascular Smooth Muscles

2002 • 128 citations

The sphingosine 1‐phosphate receptor S1P₄ regulates cell shape and motility via coupling to G_i and G_12/13

2003 • 125 citations

Sphingosine‐1‐phosphate stimulates contraction of human airway smooth muscle cells

2003 • 124 citations

Nrg-1 Belongs to the Endothelial Differentiation Gene Family of G Protein-coupled Sphingosine-1-phosphate Receptors

2001 • 121 citations

S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate

2003 • 119 citations

Sphingosine 1-phosphate and control of vascular tone

2003 • 119 citations

K+ depolarization induces RhoA kinase translocation to caveolae and Ca²⁺sensitization of arterial muscle

2003 • 105 citations

Sphingosine‐1‐phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro

2000 • 103 citations

New insights into the role of the mast cell in asthma

2003 • 100 citations

Sphingosine 1-Phosphate Contracts Canine Basilar Arteries In Vitro and In Vivo

2001 • 100 citations

Pleiotropic actions of sphingosine-1-phosphate

2003 • 100 citations

Transduction of Multiple Effects of Sphingosine 1-Phosphate (S1P) on T Cell Functions by the S1P1 G Protein-Coupled Receptor

2003 • 99 citations

Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P₁and S1P₂

2004 • 94 citations

Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function

2003 • 92 citations

Smooth Muscle Myosin Phosphatase-associated Kinase Induces Ca2+ Sensitization via Myosin Phosphatase Inhibition

2002 • 89 citations

Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase

2002 • 86 citations

Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner

2000 • 84 citations

Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase

2002 • 83 citations

Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton

2002 • 82 citations

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

2000 • 73 citations

Inhibition of High K+-Induced Contraction by the ROCKs Inhibitor Y-27632 in Vascular Smooth Muscle: Possible Involvement of ROCKs in a Signal Transduction Pathway

2003 • 67 citations

Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator

2001 • 67 citations

Phosphorylation of the Myosin-binding Subunit of Myosin Phosphatase by Raf-1 and Inhibition of Phosphatase Activity

2002 • 56 citations

Effects of the Phosphorylation of Myosin Phosphatase by Cyclic GMP-dependent Protein Kinase

1999 • 54 citations

ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and labor

2003 • 54 citations

Heterologous desensitization of response mediated by selective PKC-dependent phosphorylation of G_i-1and G_i-2

2000 • 53 citations

Recent developments in the management of interstitial cystitis

2003 • 52 citations

Regions of the 110‐kDa Regulatory Subunit M₁₁₀ Required for Regulation of Myosin‐Light‐Chain‐Phosphatase Activity in Smooth Muscle

1996 • 49 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1999 • 37 citations

Sphingosine-1-Phosphate Inhibits C-Type Natriuretic Peptide Activation of Guanylyl Cyclase B (GC-B/NPR-B)

2004 • 32 citations

Nifedipine inhibits sphingosine-1-phosphate-induced renovascular contraction in vitro and in vivo

2001 • 24 citations

Highly Effective Non-Viral Gene Transfer into Vascular Smooth Muscle Cells of Cultured Resistance Arteries Demonstrated by Genetic Inhibition of Sphingosine-1-Phosphate-Induced Vasoconstriction

2003 • 19 citations