The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Apoptosis in neurodegenerative disorders

2000 • 1,542 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.

1994 • 532 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory

2000 • 364 citations

Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins

2001 • 284 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

1998 • 263 citations

Assessment of Animal Models for MS and Demyelinating Disease in the Design of Rational Therapy

1999 • 245 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols

2000 • 214 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

1999 • 175 citations

FTY720: ALTERED LYMPHOCYTE TRAFFIC RESULTS IN ALLOGRAFT PROTECTION

2001 • 175 citations

FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking

1998 • 172 citations

FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation

2000 • 166 citations

Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

1997 • 157 citations

CC Chemokine Receptor 7–dependent and –independent Pathways for Lymphocyte Homing

2001 • 126 citations

Traumatic Brain Injury Elevates the Alzheimer's Amyloid Peptide Aβ₄₂ in Human CSF: A Possible Role for Nerve Cell Injury

2000 • 92 citations

Characterization of the Human and Mouse Sphingosine 1-Phosphate Receptor, S1P₅ (Edg-8): Structure−Activity Relationship of Sphingosine1-Phosphate Receptors

2001 • 86 citations

Immunosuppression by cyclosporin a of experimental allergic encephalomyelitis

1982 • 69 citations

Differential Activation of c-Jun NH2-Terminal Kinase and p38 Pathways During FTY720-Induced Apoptosis of T Lymphocytes That Is Suppressed by the Extracellular Signal-Regulated Kinase Pathway

1999 • 61 citations

How do neurons die in neurodegenerative diseases?

2001 • 60 citations

The Prevalence of Osteopenia in Pediatric Renal Allograft Recipients Varies with the Method of Analysis

2001 • 53 citations

EDG Receptors as a Therapeutic Target in the Nervous System

2000 • 35 citations

Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis

2001 • 32 citations

COMBINED FTY720/CYCLOSPORINE TREATMENT PROMOTES GRAFT SURVIVAL AND LOWERS THE PERIPHERAL LYMPHOCYTE COUNT IN A MURINE CARDIAC ALLOTRANSPLANTATION MODEL

2001 • 25 citations