Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

2002 • 723 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

1999 • 412 citations

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

1999 • 411 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

2000 • 393 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood

2002 • 254 citations

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

2000 • 231 citations

Comparison of Intrinsic Activities of the Putative Sphingosine 1-Phosphate Receptor Subtypes to Regulate Several Signaling Pathways in Their cDNA-transfected Chinese Hamster Ovary Cells

1999 • 219 citations

Molecular Cloning and Characterization of a Lysophosphatidic Acid Receptor, Edg-7, Expressed in Prostate

2000 • 206 citations

Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery

2000 • 184 citations

Recombinant Human G Protein-Coupled Lysophosphatidic Acid Receptors Mediate Intracellular Calcium Mobilization

1998 • 163 citations

Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors.

2001 • 153 citations

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

1998 • 149 citations

Lysophosphatidic acid as a novel cell survival/apoptotic factor

2002 • 134 citations

Role of lysophosphatidic acid and Rho in glioma cell motility

2000 • 104 citations

Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells

2000 • 101 citations

Activity of 2-Substituted Lysophosphatidic Acid (LPA) Analogs at LPA Receptors: Discovery of a LPA₁/LPA₃Receptor Antagonist

2001 • 98 citations

Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane

2001 • 96 citations

Mildly Oxidized Low Density Lipoprotein Rapidly Stimulates via Activation of the Lysophosphatidic Acid Receptor Src Family and Syk Tyrosine Kinases and Ca2+ Influx in Human Platelets

2000 • 87 citations

Possible Involvement of Cell Surface Receptors in Sphingosine 1-Phosphate-Induced Activation of Extracellular Signal-Regulated Kinase in C6 Glioma Cells

1999 • 74 citations

Reciprocal modulation of thyrotropin actions by P1-purinergic agonists in FRTL-5 thyroid cells. Inhibition of cAMP pathway and stimulation of phospholipase C-Ca2+ pathway

1991 • 73 citations

Pertussis Toxin Inhibits Phospholipase C Activation and Ca2+ Mobilization by Sphingosylphosphorylcholine and Galactosylsphingosine in HL60 Leukemia Cells

1995 • 73 citations

Exogenous Sphingosine 1-Phosphate Induces Neurite Retraction Possibly through a Cell Surface Receptor in PC12 Cells

1997 • 71 citations

The Role and Clinical Applications of Bioactive Lysolipids in Ovarian Cancer

2001 • 55 citations

Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells

2000 • 49 citations

Endothelial Differentiation Gene-2 Receptor Is Involved in Lysophosphatidic Acid-dependent Control of 3T3F442A Preadipocyte Proliferation and Spreading

2001 • 46 citations

βγ Subunits of Pertussis Toxin-sensitive G Proteins Mediate A1 Adenosine Receptor Agonist-induced Activation of Phospholipase C in Collaboration with Thyrotropin

1997 • 42 citations

Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells

2000 • 42 citations

Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells

1998 • 25 citations

Reciprocal modulation of thyrotropin actions by P[1]-purinergic agonists in FRTL-5 thyroid cells : inhibition of cAMP pathway and stimulation of phospholipase C-Ca[2+] pathway

1991 • 5 citations