Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Biologically active sphingolipids in cancer pathogenesis and treatment

2004 • 1,191 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Discovery and evaluation of inhibitors of human sphingosine kinase.

2003 • 586 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

An oncogenic role of sphingosine kinase

2000 • 394 citations

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

2002 • 394 citations

Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction

1997 • 354 citations

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

2002 • 341 citations

Sphingosine in apoptosis signaling

2002 • 320 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Sphingosine Kinase Type 1 Promotes Estrogen-Dependent Tumorigenesis of Breast Cancer MCF-7 Cells

2002 • 227 citations

Pgp and MRP Activities Using Calcein-AM Are Prognostic Factors in Adult Acute Myeloid Leukemia Patients

1998 • 208 citations

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

2001 • 193 citations

Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation

2000 • 186 citations

Enzymatic Measurement of Sphingosine 1-Phosphate

1999 • 182 citations

Loss of ceramide production confers resistance to radiation-induced apoptosis.

1997 • 162 citations

Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells.

2000 • 156 citations

Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia.

2003 • 146 citations

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

2001 • 139 citations

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

2005 • 136 citations

Down-regulation of Sphingosine Kinase-1 by DNA Damage

2004 • 129 citations

Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling.

1997 • 126 citations

Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.

1991 • 123 citations

Multidrug resistance in haematological malignancies

2000 • 111 citations

1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.

1998 • 107 citations

A Novel Enzyme That Catalyzes the Esterification of -Acetylsphingosine

1996 • 94 citations

Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells.

1992 • 94 citations

P-glycoprotein in Acute Myeloid Leukaemia: Therapeutic Implications of its Association With Both a Multidrug-resistant and an Apoptosis-resistant Phenotype

2002 • 86 citations

Multidrug resistance in haematological malignancies

2000 • 85 citations

Quantitative Determination of Ceramide Using Diglyceride Kinase

2000 • 83 citations

The Involvement of Sphingolipids in Multidrug Resistance

2001 • 83 citations

Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation

1998 • 79 citations

Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.

1991 • 66 citations

The Signal Modulator Protein-14-3-3 Ts a Target of Sphingosine-Dependent or N,N-Dimethylsphingosine-Dependent Kinase in 3T3(A31) Cells

1995 • 65 citations

In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells.

1997 • 62 citations

Protein kinase C and platelet inhibition by D-erythro-sphingosine: Comparison with N,N-dimethylsphingosine and commercial preparation

1990 • 56 citations

F-12509A, a New Sphingosine Kinase Inhibitor, Produced by a Discomycete.

2000 • 51 citations

Inhibition of Recombinant Sphingosine Kinases by Novel Inhibitors of Microbial Origin, F-12509A and B-5354c.

2002 • 39 citations

Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine

2002 • 32 citations

β2-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein

2001 • 26 citations

Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant

2002 • 21 citations

Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells

1998 • 21 citations

Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1

2003 • 18 citations