Point-Counterpoint of Sphingosine 1-Phosphate Metabolism

Molecular regulation of vessel maturation

2003 • 2,446 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis

2001 • 1,067 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

2003 • 523 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Radiation and ceramide-induced apoptosis

2003 • 487 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

2003 • 427 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Sphingosine Kinase 2 Is a Nuclear Protein and Inhibits DNA Synthesis

2003 • 407 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

2000 • 401 citations

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

2000 • 393 citations

Dengue Virus Infection of Human Endothelial Cells Leads to Chemokine Production, Complement Activation, and Apoptosis

1998 • 377 citations

Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability

2003 • 375 citations

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation

2003 • 373 citations

Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis

2003 • 352 citations

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

2002 • 305 citations

PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane

2002 • 293 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

2001 • 284 citations

Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins

2001 • 284 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases

2002 • 275 citations

Signaling and biological actions of sphingosine 1-phosphate

2003 • 272 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells

2001 • 268 citations

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

2002 • 265 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G_12/13-Rho and G_i Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform

2003 • 259 citations

Preservation of Vascular Integrity in Organs perfused in vitro with a Platelet-rich Medium

1969 • 249 citations

Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response

1998 • 244 citations

Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3

2002 • 241 citations

Palmitate Inhibition of Insulin Gene Expression Is Mediated at the Transcriptional Level via Ceramide Synthesis

2003 • 239 citations

The BST1 Gene of Saccharomyces cerevisiaeIs the Sphingosine-1-phosphate Lyase

1997 • 235 citations

Identification of a Novel Role for Sphingolipid Signaling in TNF α and Ischemic Preconditioning Mediated Cardioprotection

2002 • 233 citations

Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

2002 • 228 citations

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.

2003 • 223 citations

High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors

2003 • 220 citations

The Drosophila protein Wunen repels migrating germ cells

1997 • 205 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation

2000 • 186 citations

The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases

1998 • 184 citations

The SREBP Pathway in Drosophila

2002 • 182 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate

2003 • 176 citations

Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2

2003 • 172 citations

Identification of the First Mammalian Sphingosine Phosphate Lyase Gene and Its Functional Expression in Yeast

1998 • 168 citations

Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration

2001 • 166 citations

The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning

2003 • 166 citations

Roles for lipid phosphate phosphatases in regulation of cellular signaling

2002 • 163 citations

Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis

2002 • 163 citations

Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability

2003 • 161 citations

Agonist-modulated Targeting of the EDG-1 Receptor to Plasmalemmal Caveolae

2000 • 159 citations

Sphingosine kinases: A novel family of lipid kinases

2002 • 158 citations

Role of Sphingosine 1-Phosphate in the Mitogenesis Induced by Oxidized Low Density Lipoprotein in Smooth Muscle Cells via Activation of Sphingomyelinase, Ceramidase, and Sphingosine Kinase

1999 • 157 citations

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase

1997 • 154 citations

Sphingosine-1-phosphate markedly induces matrix metalloproteinase and integrin-dependent human endothelial cell invasion and lumen formation in three-dimensional collagen and fibrin matrices

2003 • 150 citations

Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis

2004 • 147 citations

Chemical Composition of Nuclei of Z > 22 in Cosmic Rays using Meteoritic Minerals as Detectors

1969 • 137 citations

Lysophosphatidic Acid-induced Mitogenesis Is Regulated by Lipid Phosphate Phosphatases and Is Edg-receptor Independent

2001 • 136 citations

An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases

1997 • 134 citations

Analysis of Phosphorylated Sphingolipid Long-Chain Bases Reveals Potential Roles in Heat Stress and Growth Control in Saccharomyces

1999 • 133 citations

Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction

1999 • 131 citations

Cell Type-specific Localization of Human Cardiac S1P Receptors

2002 • 120 citations

Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids

2002 • 119 citations

Sphingosine 1-phosphate and control of vascular tone

2003 • 119 citations

Endothelial cell apoptosis in sepsis

2002 • 118 citations

Metabolism and functional effects of sphingolipids in blood cells

1999 • 116 citations

Splyregulation of sphingolipid signaling molecules is essential for Drosophila development

2003 • 114 citations

The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses

1999 • 114 citations

BcR-induced Apoptosis Involves Differential Regulation of C16 and C24-Ceramide Formation and Sphingolipid-dependent Activation of the Proteasome

2003 • 111 citations

Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q2211DNA sequence was deposited in the EMBL database (AJ011304).

2000 • 108 citations

The Nucleotide-binding Site of Human Sphingosine Kinase 1

2002 • 105 citations

Sphingosine-1-Phosphate Phosphatases

2001 • 101 citations

Sphingosine 1-Phosphate Contracts Canine Basilar Arteries In Vitro and In Vivo

2001 • 100 citations

[28] Sphingosine-1-phosphate lyase

2000 • 97 citations

EDG1 Receptor Stimulation Leads to Cardiac Hypertrophy in Rat Neonatal Myocytes

2001 • 96 citations

Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation

2001 • 94 citations

Identification of a Saccharomyces Gene,LCB3, Necessary for Incorporation of Exogenous Long Chain Bases into Sphingolipids

1997 • 93 citations

Metabolism and functional effects of sphingolipids in blood cells

1999 • 90 citations

De Novo Ceramide Synthesis Participates in the Ultraviolet B Irradiation-Induced Apoptosis in Undifferentiated Cultured Human Keratinocytes

2003 • 89 citations

Transcriptome Analysis Reveals a Role of Interferon-γ in Human Neointima Formation

2001 • 89 citations

Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors

2002 • 87 citations

Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner

2000 • 84 citations

Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium The GenBank accession numbers for the sequences reported in this paper are AF233610 (S-1-P lyase), AF233612 (PIP5K), AF233611 (P2Y purine receptor 1), AF233613 (CAAX prenyl protease) and AF233614 (unidentified gene).

2000 • 82 citations

cis-4-Methylsphingosine Decreases Sphingolipid Biosynthesis by Specifically Interfering with Serine Palmitoyltransferase Activity in Primary Cultured Neurons

1997 • 76 citations

Sphingosine-1-phosphate Lyase Is Involved in the Differentiation of F9 Embryonal Carcinoma Cells to Primitive Endoderm

2003 • 75 citations

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

2000 • 73 citations

TheDPL1Gene Is Involved in Mediating the Response to Nutrient Deprivation inSaccharomyces cerevisiae

1999 • 70 citations

Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum

2001 • 67 citations

Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans

2003 • 65 citations

Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants

1998 • 62 citations

High-Performance Liquid Chromatography Analysis of Molecular Species of Sphingolipid-Related Long Chain Bases and Long Chain Base Phosphates in Saccharomyces cerevisiae after Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate

2001 • 55 citations

Identification of functional nuclear export sequences in human sphingosine kinase 1

2003 • 53 citations

Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast

2002 • 50 citations

Expression and characterization of Edg‐1 receptors in rat cardiomyocytes

2000 • 46 citations

Asnc1Endocytosis Mutant: Phenotypic Analysis and Suppression by Overproduction of Dihydrosphingosine Phosphate Lyase

2000 • 41 citations

Induction of apoptosis using sphingolipids activates a chloride current inXenopus laevisoocytes

2000 • 40 citations

Platelet‐derived growth factor (PDGF)‐induced chemotaxis does not require the G protein‐coupled receptor S1P₁ in murine embryonic fibroblasts and vascular smooth muscle cells

2002 • 33 citations

Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis

2003 • 32 citations

Sphingosine 1-Phosphate Formation and Intracellular Ca2+ Mobilization in Human Platelets: Evaluation with Sphingosine Kinase Inhibitors

1999 • 26 citations

Stimulation by de novo-synthesized ceramide of phospholipase A2-dependent cholesterol esterification promoted by the uptake of oxidized low-density lipoprotein in macrophages

2002 • 18 citations

[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors].

2002 • 2 citations