Ligand-induced Trafficking of the Sphingosine-1-phosphate Receptor EDG-1

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Endocytosis

1997 • 1,263 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1997 • 697 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum

1997 • 442 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 • 332 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

G-protein-coupled receptors: turn-ons and turn-offs

1998 • 277 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Activator proteins and topology of lysosomal sphingolipid catabolism

1992 • 269 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

1996 • 264 citations

Simultaneous imaging of cell and mitochondrial membrane potentials

1989 • 262 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

Dynamic Distribution of Chemoattractant Receptors in Living Cells During Chemotaxis and Persistent Stimulation

1997 • 234 citations

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

1992 • 223 citations

Internal Trafficking and Surface Mobility of a Functionally Intact β₂-Adrenergic Receptor-Green Fluorescent Protein Conjugate

1997 • 220 citations

Cloning of cDNAs Encoding G Protein-Coupled Receptor Expressed in Human Endothelial Cells Exposed to Fluid Shear Stress

1997 • 209 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Visualization of G Protein-coupled Receptor Trafficking with the Aid of the Green Fluorescent Protein

1997 • 176 citations

The Inducible G Protein-coupled Receptor edg-1 Signals via the Gi/Mitogen-activated Protein Kinase Pathway

1996 • 167 citations

Discussion

1999 • 154 citations

Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting

1998 • 125 citations

Lysophosphatidic Acid Stimulates the G-protein-coupled Receptor EDG-1 as a Low Affinity Agonist

1998 • 116 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

The Mouse Gene for the Inducible G-Protein-Coupled Receptoredg-1

1997 • 75 citations

Intracellular trafficking of glycosphingolipids: Role of sphingolipid activator proteins in the topology of endocytosis and lysosomal digestion

1994 • 50 citations

Sphingosine kinase: properties and cellular functions.

1993 • 46 citations

Induction of Apoptosis by Sphingosine-1-Phosphate in Human Hepatoma Cells Is Associated with Enhanced Expression of bax Gene Product

1996 • 38 citations