Cardiovascular effects of sphingosine‐1‐phosphate and other sphingomyelin metabolites

Angiogenesis in health and disease

2003 • 4,127 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

1997 • 2,136 citations

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.

1998 • 1,191 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

2004 • 619 citations

Long-term control of arterial blood pressure

1992 • 589 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

2002 • 462 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 458 citations

Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum

1997 • 442 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

2002 • 394 citations

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation

2003 • 373 citations

Impaired wound healing and angiogenesis in eNOS-deficient mice

1999 • 372 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Sphingosine 1-Phosphate Induces Angiogenesis: Its Angiogenic Action and Signaling Mechanism in Human Umbilical Vein Endothelial Cells

1999 • 359 citations

Intracellular signal transduction pathways activated by ceramide and its metabolites

2003 • 348 citations

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

2002 • 341 citations

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

2004 • 329 citations

Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac Myocyte

1997 • 324 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins

2001 • 284 citations

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

2000 • 276 citations

Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases

2002 • 275 citations

Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3

2001 • 271 citations

Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells

2001 • 268 citations

Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5

1999 • 255 citations

Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase

2001 • 241 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

2000 • 231 citations

Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

2002 • 228 citations

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.

2003 • 223 citations

High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors

2003 • 220 citations

Sphingosine-1-Phosphate, a Platelet-Derived Lysophospholipid Mediator, Negatively Regulates Cellular Rac Activity and Cell Migration in Vascular Smooth Muscle Cells

2002 • 219 citations

Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion.

1997 • 202 citations

Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors

2002 • 201 citations

Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide Production

2001 • 201 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

Functions of a new family of sphingosine-1-phosphate receptors

2000 • 194 citations

VEGF induces S1P ₁ receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors

2003 • 190 citations

Sphingosine‐1‐phosphate: dual messenger functions

2002 • 188 citations

Transactivation of Vascular Endothelial Growth Factor (VEGF) Receptor Flk-1/KDR Is Involved in Sphingosine 1-Phosphate-stimulated Phosphorylation of Akt and Endothelial Nitric-oxide Synthase (eNOS)

2002 • 188 citations

Myocardial Dysfunction With Coronary Microembolization

2002 • 187 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors

2002 • 172 citations

IFN-γ–mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, α-galactosylceramide

2002 • 171 citations

The Lysophospholipids Sphingosine-1-Phosphate and Lysophosphatidic Acid Enhance Survival during Hypoxia in Neonatal Rat Cardiac Myocytes

2001 • 170 citations

Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration

2001 • 166 citations

Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKCε knockout mouse hearts

2002 • 155 citations

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

2003 • 155 citations

Platelet-released phospholipids link haemostasis and angiogenesis

2001 • 153 citations

Sphingosine-1-phosphate markedly induces matrix metalloproteinase and integrin-dependent human endothelial cell invasion and lumen formation in three-dimensional collagen and fibrin matrices

2003 • 150 citations

Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate

1999 • 147 citations

Sphingosine-1-phosphate receptors and the development of the vascular system

2002 • 145 citations

Differential Regulation of Sphingosine-1-Phosphate- and VEGF-Induced Endothelial Cell Chemotaxis

2001 • 144 citations

Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase

2003 • 142 citations

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

2001 • 142 citations

Sphingosylphosphorylcholine—biological functions and mechanisms of action

2002 • 132 citations

Sphingosylphosphorylcholine Is a Novel Messenger for Rho-Kinase–Mediated Ca ²⁺ Sensitization in the Bovine Cerebral Artery

2002 • 130 citations

Nitric Oxide-Induced Decrease in Calcium Sensitivity of Resistance Arteries Is Attributable to Activation of the Myosin Light Chain Phosphatase and Antagonized by the RhoA/Rho Kinase Pathway

2003 • 129 citations

Comparison of Sphingosine 1-Phosphate–Induced Intracellular Signaling Pathways in Vascular Smooth Muscles

2002 • 128 citations

A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes.

1996 • 123 citations

Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate–Induced Angiogenesis

2002 • 121 citations

Cell Type-specific Localization of Human Cardiac S1P Receptors

2002 • 120 citations

Sphingosine 1-phosphate and control of vascular tone

2003 • 119 citations

S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate

2003 • 119 citations

Requirement of Ryanodine Receptor Subtypes 1 and 2 for Ca2+-induced Ca2+ Release in Vascular Myocytes

2000 • 118 citations

Rapid Activation of Neutral Sphingomyelinase by Hypoxia-Reoxygenation of Cardiac Myocytes

2000 • 116 citations

Molecular diversity of sphingolipid signalling

1997 • 108 citations

Activation of muscarinic K+ current in guinea‐pig atrial myocytes by sphingosine‐1‐phosphate.

1995 • 106 citations

Killing tumours by ceramide-induced apoptosis: a critique of available drugs

2003 • 106 citations

Sphingosine-1-Phosphate and Lysophosphatidic Acid Stimulate Endothelial Cell Migration

2000 • 103 citations

Sphingosine‐1‐phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro

2000 • 103 citations

Sphingosine 1-Phosphate Induces Membrane Ruffling and Increases Motility of Human Umbilical Vein Endothelial Cells via Vascular Endothelial Growth Factor Receptor and CrkII

2002 • 102 citations

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

2001 • 102 citations

Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells

2000 • 101 citations

Sphingosine 1-Phosphate Contracts Canine Basilar Arteries In Vitro and In Vivo

2001 • 100 citations

Cellular Basis for the Acute Inhibitory Effects of IL-6 and TNF- on Excitation-contraction Coupling

1999 • 98 citations

Membrane type 1–matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1–phosphate to induce endothelial cell migration and morphogenic differentiation

2003 • 97 citations

EDG1 Receptor Stimulation Leads to Cardiac Hypertrophy in Rat Neonatal Myocytes

2001 • 96 citations

Involvement of Src Family Protein Tyrosine Kinases in Ca ²⁺ Sensitization of Coronary Artery Contraction Mediated by a Sphingosylphosphorylcholine-Rho-Kinase Pathway

2002 • 94 citations

Evidence for Edg-3 Receptor-Mediated Activation ofI_K.ACh by Sphingosine-1-Phosphate in Human Atrial Cardiomyocytes

2000 • 85 citations

Ceramide Signaling in Fenretinide-induced Endothelial Cell Apoptosis

2002 • 84 citations

Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner

2000 • 84 citations

Control of cardiac Ca2+ levels. Inhibitory actions of sphingosine on Ca2+ transients and L-type Ca2+ channel conductance.

1994 • 83 citations

Ceramide Reduces Endothelium-Dependent Vasodilation by Increasing Superoxide Production in Small Bovine Coronary Arteries

2001 • 82 citations

The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide

2000 • 80 citations

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

2000 • 73 citations

Lipid mediators of angiogenesis and the signalling pathways they initiate

2002 • 72 citations

Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells

1999 • 70 citations

Arachidonic acid mediates dual effect of TNF-α on Ca²⁺ transients and contraction of adult rat cardiomyocytes

2002 • 69 citations

The G Protein-Coupled Receptor GPR4 Suppresses ERK Activation in a Ligand-Independent Manner

2003 • 69 citations

Sphingosylphosphorylcholine Induces Endothelial Cell Migration and Morphogenesis

2000 • 68 citations

Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63

2003 • 68 citations

Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator

2001 • 67 citations

Migration of Vascular Smooth Muscle Cells Induced by Sphingosine 1-Phosphate and Related Lipids: Potential Role in the Angiogenic Response

2002 • 65 citations

Modulation of Cardiac Sarcoplasmic Reticulum Ryanodine Receptor by Sphingosine

1994 • 64 citations

Sphingosylphosphorylcholine induces Ca²⁺‐sensitization of vascular smooth muscle contraction: possible involvement of Rho‐kinase

2000 • 64 citations

Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca²⁺-dependent pathway

1998 • 59 citations

Sphingosylphosphorylcholine Induces a Hypertrophic Growth Response Through the Mitogen-Activated Protein Kinase Signaling Cascade in Rat Neonatal Cardiac Myocytes

1999 • 49 citations

Effect of Ceramide on K _Ca Channel Activity and Vascular Tone in Coronary Arteries

1999 • 48 citations

Expression and characterization of Edg‐1 receptors in rat cardiomyocytes

2000 • 46 citations

Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes

1997 • 46 citations

Sphingosylphosphorylcholine induces cytosolic Ca²⁺ elevation in endothelial cells in situ and causes endothelium‐dependent relaxation through nitric oxide production in bovine coronary artery

1999 • 43 citations

Ceramide: A Novel Cell Signaling Mechanism for Vasodilation

1997 • 42 citations

Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells

2000 • 42 citations

Sphingolipid actions on sodium and calcium currents of rat ventricular myocytes

1996 • 37 citations

Lysosphingolipid receptor‐mediated diuresis and natriuresis in anaesthetized rats

2001 • 36 citations

Sphingosine Modulates Myocyte Electrophysiology, Induces Negative Inotropy, and Decreases Survival After Myocardial Ischemia

2002 • 33 citations

Sphingosine Effects on the Contractile Behavior of Skinned Cardiac Myocytes

1994 • 32 citations

Ceramide mimics tumour necrosis factor‐α in the induction of cell cycle arrest in endothelial cells

2000 • 31 citations

Isolation of immediate-early differentiation mRNAs by enzymatic amplification of subtracted cDNA from human endothelial cells

1990 • 30 citations

Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System

2000 • 30 citations

Fluid Shear Stress Differentially Regulates gpr3, gpr6, and gpr12 Expression in Human Umbilical Vein Endothelial Cells

2003 • 30 citations

Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels

2003 • 30 citations

Effects of sphingomyelinase and sphingosine on arterial vasomotor regulation.

1996 • 28 citations

Acute exposure of ceramide enhances cardiac contractile function in isolated ventricular myocytes

2003 • 27 citations

Depression of excitability by sphingosine 1-phosphate in rat ventricular myocytes

1998 • 26 citations

Impaired ceramide signalling in spontaneously hypertensive rat vascular smooth muscle: a possible mechanism for augmented cell proliferation

2001 • 26 citations

Nifedipine inhibits sphingosine-1-phosphate-induced renovascular contraction in vitro and in vivo

2001 • 24 citations

Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine

2003 • 22 citations

Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells

2003 • 22 citations

C₂‐ceramide attenuates phenylephrine‐induced vasoconstriction and elevation in [Ca²⁺]_i in rat aortic smooth muscle

1999 • 20 citations

Transient relaxation of rat mesenteric microvessels by ceramides

2002 • 20 citations

Increased myocardial oxygen consumption by TNF-α is mediated by a sphingosine signaling pathway

2003 • 19 citations

Distinct Ca²⁺ signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells

2000 • 16 citations

The role of the endothelium in ceramide-induced vasodilation

1998 • 15 citations

Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca²⁺influx

2003 • 14 citations

Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine

2003 • 10 citations

Effect of sphingosylphosphorylcholine on the single channel gating properties of the cardiac ryanodine receptor

1999 • 9 citations

Sphingosine modulation of cAMP levels and beating rate in rat heart

2002 • 4 citations