Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells

1987 • 1,189 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

1998 • 601 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Signal transduction through lipid second messengers

1996 • 496 citations

Gene for Familial Psoriasis Susceptibility Mapped to the Distal End of Human Chromosome 17q

1994 • 437 citations

Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan

1997 • 418 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Genomewide Scan of Multiple Sclerosis in Finnish Multiplex Families

1997 • 308 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Purification and Characterization of Rat Kidney Sphingosine Kinase

1998 • 221 citations

A genome scan localizes five non–MHC loci controlling collagen–induced arthritis in rats

1996 • 212 citations

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.

1992 • 193 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking

1998 • 172 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts

1997 • 112 citations

A Susceptibility Locus for Epidermodysplasia Verruciformis, an Abnormal Predisposition to Infection with the Oncogenic Human Papillomavirus Type 5, Maps to Chromosome 17qter in a Region Containing a Psoriasis Locus

1999 • 110 citations

Regulatory Effect of Phorbol Esters on Sphingosine Kinase in BALB/C 3T3 Fibroblasts (Variant A31): Demonstration of Cell Type-Specific Response - A Preliminary Note

1994 • 87 citations

Analysis of Three Suggested Psoriasis Susceptibility Loci in a Large Swedish Set of Families: Confirmation of Linkage to Chromosome 6p (HLA Region), and to 17q, but not to 4q

1999 • 81 citations

Sphingosine Kinase from Swiss 3T3 Fibroblasts: A Convenient Assay for the Measurement of Intracellular Levels of Free Sphingoid Bases

1994 • 73 citations

Sphingosine Kinase in Blood Platelets

1973 • 66 citations

Metabolism of Sphingosine Bases, XIII. Enzymatic Synthesis of 1-Phosphate Esters of 4t-Sphingenine (Sphingosine), Sphinganine (Dihydrosphingosine), 4-Hydroxysphinganine (Phytosphingosine) and 3-Dehydrosphinganine by Erythrocytes

1970 • 57 citations

Enzymatic Formation of Dihydrosphingosine 1-Phosphate

1970 • 50 citations

Metabolism of Sphingosine Bases, VI. Synthesis and Degradation of Sphingosine Bases inHansenula ciferrii

1968 • 35 citations

The enzymatic phosphorylation of sphinganine

1969 • 32 citations

Sphingolipid base phosphorylation by cell-free preparations from Tetrahymena pyriformis

1972 • 20 citations