Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

1998 • 10,251 citations

Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94

1996 • 4,827 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Prediction of structure and function of G protein-coupled receptors

2002 • 286 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Signaling and biological actions of sphingosine 1-phosphate

2003 • 272 citations

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

2002 • 265 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Sphingosine-1-Phosphate, a Platelet-Derived Lysophospholipid Mediator, Negatively Regulates Cellular Rac Activity and Cell Migration in Vascular Smooth Muscle Cells

2002 • 219 citations

Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist

2002 • 191 citations

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

2000 • 174 citations

Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems

2001 • 173 citations

Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors

2002 • 172 citations

Ligand-dependent Inhibition of B16 Melanoma Cell Migration and Invasion via Endogenous S1P2 G Protein-coupled Receptor

2003 • 156 citations

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

2003 • 155 citations

Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate

2000 • 155 citations

Edg-6 as a Putative Sphingosine 1-Phosphate Receptor Coupling to Ca2+ Signaling Pathway

2000 • 154 citations

Simultaneous Quantitative Analysis of Sphingoid Base 1-Phosphates in Biological Samples by o-Phthalaldehyde Precolumn Derivatization after Dephosphorylation with Alkaline Phosphatase

2002 • 149 citations

The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints

1997 • 147 citations

The sphingosine 1‐phosphate receptor S1P₄ regulates cell shape and motility via coupling to G_i and G_12/13

2003 • 125 citations

A Single Amino Acid Determines Lysophospholipid Specificity of the S1P1 (EDG1) and LPA1 (EDG2) Phospholipid Growth Factor Receptors

2001 • 110 citations

Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells

2003 • 109 citations

Photolysis of intracellular caged sphingosine‐1‐phosphate causes Ca²⁺ mobilization independently of G‐protein‐coupled receptors

2003 • 97 citations

Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

2001 • 95 citations

Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation

2003 • 89 citations

A1 adenosine receptors. Two amino acids are responsible for species differences in ligand recognition.

1994 • 87 citations

Characterization of the Human and Mouse Sphingosine 1-Phosphate Receptor, S1P₅ (Edg-8): Structure−Activity Relationship of Sphingosine1-Phosphate Receptors

2001 • 86 citations

N‐Glycans of sphingosine 1‐phosphate receptor Edg‐1 regulate ligand‐induced receptor internalization

2002 • 71 citations

Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway

2003 • 70 citations

Phytosphingosine 1-phosphate: a high affinity ligand for the S1P4/Edg-6 receptor

2002 • 56 citations

Synthesis of para-Alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists

2003 • 53 citations

Sphingosine 1‐phosphate promotes cell migration through the activation of Cdc42 in Edg‐6/S1P4‐expressing cells

2003 • 47 citations

Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands

2004 • 43 citations

Functional Role of Tryptophan Residues in the Fourth Transmembrane Domainof the CB₂ Cannabinoid Receptor

2000 • 40 citations

Physiological sphingosine 1‐phosphate requirement for optimal activity of mouse CD4⁺25⁺regulatory T Cells

2004 • 39 citations

Lipid Receptors in Cardiovascular Development

2003 • 37 citations

Biochemical regulation of breast cancer cell expression of S1P₂ (Edg‐5) and S1P₃ (Edg‐3) G protein‐coupled receptors for sphingosine 1‐phosphate

2002 • 32 citations

Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

2004 • 29 citations

Synthesis of fluorescence-Labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior

2003 • 28 citations

Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors

2004 • 28 citations

Total Synthesis of Two Photoactivatable Analogues of the Growth-Factor-Like Mediator Sphingosine 1-Phosphate: Differential Interaction with Protein Targets

2003 • 26 citations

Structural Features of EDG1 Receptor‐Ligand Complexes Revealed by Computational Modeling and Mutagenesis

2000 • 26 citations

Syntheses of sphingosine-1-phosphate stereoisomers and analogues and Their interaction with EDG receptors

2003 • 24 citations

A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.

2004 • 21 citations

Sphingosine-1-Phosphate,a Platelet-Derived Lysophospholipid Mediator, Negatively Regulates Cellular Rac Activity and Cell Migration in Vascular Smooth Muscle Cells

2004 • 18 citations

Pharmacological characterization of human S1P₄ using a novel radioligand, [4,5‐³H]‐dihydrosphingosine‐1‐phosphate

2004 • 12 citations