Thrombogenic and atherogenic activities of lysophosphatidic acid

A Critical Role of Platelet Adhesion in the Initiation of Atherosclerotic Lesion Formation

2002 • 847 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways

2002 • 413 citations

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

1999 • 411 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species

2000 • 255 citations

Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood

2002 • 254 citations

Direct Quantitative Analysis of Lysophosphatidic Acid Molecular Species by Stable Isotope Dilution Electrospray Ionization Liquid Chromatography–Mass Spectrometry

2001 • 232 citations

Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

2000 • 210 citations

Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation

2004 • 202 citations

Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

2001 • 191 citations

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

1989 • 185 citations

Leptin Induces Endothelial Cell Migration Through Akt, Which Is Inhibited by PPARγ-Ligands

2002 • 170 citations

Recombinant Human G Protein-Coupled Lysophosphatidic Acid Receptors Mediate Intracellular Calcium Mobilization

1998 • 163 citations

Dichotomous Regulation of Myosin Phosphorylation and Shape Change by Rho-Kinase and Calcium in Intact Human Platelets

1999 • 158 citations

PPAR activators inhibit endothelial cell migration by targeting Akt

2002 • 157 citations

Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate

2002 • 154 citations

Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques

2003 • 153 citations

Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors.

2001 • 153 citations

Cystic Fibrosis Transmembrane Regulator Regulates Uptake of Sphingoid Base Phosphates and Lysophosphatidic Acid

2001 • 142 citations

Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction.

1999 • 133 citations

Mildly Oxidized LDL Induces Platelet Aggregation Through Activation of Phospholipase A ₂

1995 • 132 citations

Platelet Aggregation Evoked In Vitro and In Vivo by Phosphatidic Acids and Lysoderivatives: Identity with Substances in Aged Serum (DAS)

1979 • 129 citations

The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors

2003 • 123 citations

Lysophosphatidic acid alters cerebrovascular reactivity in piglets

1995 • 120 citations

Vascular Remodeling Induced by Naturally Occurring Unsaturated Lysophosphatidic Acid In Vivo

2003 • 109 citations

Physiological responses to lysophosphatidic acid and related glycero-phospholipids

2001 • 93 citations

Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: A new group of phospholipid mediators?

1982 • 89 citations

Mildly Oxidized Low Density Lipoprotein Rapidly Stimulates via Activation of the Lysophosphatidic Acid Receptor Src Family and Syk Tyrosine Kinases and Ca2+ Influx in Human Platelets

2000 • 87 citations

A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification

2000 • 86 citations

Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate

2003 • 86 citations

Lysophosphatidic acid-induced aggregation of human and feline platelets: Structure-activity relationship

1981 • 83 citations

Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets

2003 • 83 citations

Biochemical Characterization of the Interaction of Lipid Phosphoric Acids with Human Platelets: Comparison with Platelet Activating Factor

1994 • 81 citations

Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids

2002 • 74 citations

Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1‐phosphate

2000 • 61 citations

Lysophosphatidic acid-induced platelet shape change proceeds via Rho/Rho kinase-mediated myosin light-chain and moesin phosphorylation

2000 • 58 citations

Peroxisome Proliferator–Activated Receptor-γ Ligands Inhibit Nuclear but Not Cytosolic Extracellular Signal–Regulated Kinase/Mitogen–Activated Protein Kinase–Regulated Steps in Vascular Smooth Muscle Cell Migration

2001 • 56 citations

Topographic Analysis of Proliferative Activity in Carotid Endarterectomy Specimens by Immunocytochemical Detection of the Cell Cycle–Related Antigen Ki-67

1997 • 52 citations

Mildly oxidised low density lipoprotein induces platelet shape change via Rho‐kinase‐dependent phosphorylation of myosin light chain and moesin

2000 • 43 citations

Stimulation of Platelets and Endothelial Cells by Mildly Oxidized LDL Proceeds through Activation of Lysophosphatidic Acid Receptors and the Rho/Rho‐Kinase Pathway: Inhibition by Lovastatin

2000 • 41 citations

Genetic and Pharmacological Analyses of Involvement of Src-family, Syk and Btk Tyrosine Kinases in Platelet Shape Change

2001 • 33 citations

Transbilayer movement and metabolic fate of ether-linked phosphatidic acid (1-O-Octadecyl-2-acetyl-sn-glycerol 3-phosphate) in guinea pig peritoneal polymorphonuclear leukocytes.

1992 • 26 citations