Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Ceramide in the eukaryotic stress response

2000 • 729 citations

Signal transduction of stress via ceramide

1998 • 687 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Sphingolipid Synthesis as a Target for Antifungal Drugs

1997 • 396 citations

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

1999 • 361 citations

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.

1992 • 343 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Sphingomyelin Synthase, a Potential Regulator of Intracellular Levels of Ceramide and Diacylglycerol during SV40 Transformation

1998 • 290 citations

Agents that Reverse Multidrug Resistance, Tamoxifen, Verapamil, and Cyclosporin A, Block Glycosphingolipid Metabolism by Inhibiting Ceramide Glycosylation in Human Cancer Cells

1997 • 290 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Oxidized Low Density Lipoprotein Induces Apoptosis in Cultured Human Umbilical Vein Endothelial Cells by Common and Unique Mechanisms

1998 • 258 citations

Molecular Cloning and Characterization of a Full-length Complementary DNA Encoding Human Acid Ceramidase

1996 • 244 citations

Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae

2000 • 241 citations

Molecular Cloning and Characterization of a Human Mitochondrial Ceramidase

2000 • 237 citations

Ceramide Directly Activates Protein Kinase C ζ to Regulate a Stress-activated Protein Kinase Signaling Complex

2000 • 226 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Purification and Characterization of Rat Kidney Sphingosine Kinase

1998 • 221 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

Purification, Characterization, and Biosynthesis of Human Acid Ceramidase

1995 • 209 citations

Enzymatic Hydrolysis of Sphingolipids

1966 • 204 citations

A GTPase-independent Mechanism of p21-activated Kinase Activation

1998 • 204 citations

Human and Murine Serine‐Palmitoyl‐CoA Transferase

1997 • 199 citations

Tsc3p Is an 80-Amino Acid Protein Associated with Serine Palmitoyltransferase and Required for Optimal Enzyme Activity

2000 • 189 citations

Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids

1991 • 185 citations

The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases

1998 • 184 citations

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

2000 • 177 citations

Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae

1997 • 169 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Role of Sphingosine 1-Phosphate in the Mitogenesis Induced by Oxidized Low Density Lipoprotein in Smooth Muscle Cells via Activation of Sphingomyelinase, Ceramidase, and Sphingosine Kinase

1999 • 157 citations

Bimodal Regulation of Ceramidase by Interleukin-1β

1997 • 152 citations

H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells

1998 • 151 citations

Isolation of cDNA clones encoding human acid sphingomyelinase: occurrence of alternatively processed transcripts.

1989 • 149 citations

Analysis of Phosphorylated Sphingolipid Long-Chain Bases Reveals Potential Roles in Heat Stress and Growth Control in Saccharomyces

1999 • 133 citations

Stimulation of DNA synthesis by natural ceramide 1-phosphate

1997 • 121 citations

Anti-immunoglobulin-induced Apoptosis in WEHI 231 Cells Involves the Slow Formation of Ceramide from Sphingomyelin and Is Blocked by bcl-xL

1997 • 114 citations

Inhibition of Neutral Sphingomyelinase Activation and Ceramide Formation by Glutathione in Hypoxic PC12 Cell Death

1999 • 113 citations

Activation of the de novo Biosynthesis of Sphingolipids Mediates Angiotensin II Type 2 Receptor-induced Apoptosis

1999 • 108 citations

Lactosylceramide Mediates Tumor Necrosis Factor-α-induced Intercellular Adhesion Molecule-1 (ICAM-1) Expression and the Adhesion of Neutrophil in Human Umbilical Vein Endothelial Cells

1998 • 107 citations

Function of the Cloned Putative Neutral Sphingomyelinase as Lyso-platelet Activating Factor-Phospholipase C

1999 • 102 citations

Tumor Necrosis Factor Induces Ceramide Oscillations and Negatively Controls Sphingolipid Synthases by Caspases in Apoptotic Kym-1 Cells

1998 • 100 citations

Formyl Peptide Receptor Signaling in HL-60 Cells through Sphingosine Kinase

1999 • 99 citations

Production of Ceramides Causes Apoptosis during Early Neural Differentiation in Vitro

2000 • 95 citations

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine

1990 • 87 citations

Purification and Characterization of a Membrane-bound Nonlysosomal Ceramidase from Rat Brain

1999 • 86 citations

Activation of Acid Sphingomyelinase by Interleukin-1 (IL-1) Requires the IL-1 Receptor Accessory Protein

1997 • 77 citations

Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.

1994 • 76 citations

Acid Sphingomyelinase

2013 • 76 citations

CD40 Signals Apoptosis through FAN-regulated Activation of the Sphingomyelin-Ceramide Pathway

1999 • 76 citations

Purification and Characterization of UDP-glucose:Ceramide Glucosyltransferase from Rat Liver Golgi Membranes

1996 • 75 citations

Lactosylceramide Stimulates Ras-GTP Loading, Kinases (MEK, Raf), p44 Mitogen-activated Protein Kinase, and c-fos Expression in Human Aortic Smooth Muscle Cells

1996 • 75 citations

Acid Sphingomyelinase of Human Brain: Purification to Homogeneity

1982 • 75 citations

Purification and Characterization of a Magnesium-dependent Neutral Sphingomyelinase from Bovine Brain

2000 • 73 citations

Differential Effects of Sphingomyelin Hydrolysis and Resynthesis on the Activation of NF-κB in Normal and SV40-transformed Human Fibroblasts

2000 • 72 citations

Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase

1999 • 72 citations

Molecular Cloning, Characterization, and Expression of a Novel Human Neutral Sphingomyelinase

1999 • 70 citations

Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis

1998 • 53 citations

Ceramide and apoptosis

1999 • 47 citations

Arachidonic Acid Mediates Interferon-γ–Induced Sphingomyelin Hydrolysis and Monocytic Marker Expression in HL-60 Cell Line

1997 • 44 citations