Lysophospholipid Receptors as Potential Drug Targets in Tissue Transplantation and Autoimmune Diseases

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

G Protein-coupled Receptors

1998 • 1,292 citations

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

2001 • 1,147 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

The emerging role of lysophosphatidic acid in cancer

2003 • 1,086 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Lysophospholipid Receptors: Signaling and Biology

2004 • 752 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

2004 • 619 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 611 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

2004 • 503 citations

Protective Effects of Sphingosine 1-Phosphate in Murine Endotoxin-induced Inflammatory Lung Injury

2004 • 491 citations

Requirement for the lp _A1 lysophosphatidic acid receptor gene in normal suckling behavior

2000 • 468 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

2000 • 401 citations

Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

2003 • 392 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability

2003 • 375 citations

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation

2003 • 373 citations

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory

2000 • 364 citations

Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins

2003 • 361 citations

Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

2001 • 329 citations

Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3

2000 • 328 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

Characterization of lpa₂ (Edg4) and lpa₁/lpa₂ (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa₂

2002 • 315 citations

Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors

2002 • 309 citations

Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate

2004 • 295 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

2001 • 284 citations

Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins

2001 • 284 citations

Lysophospholipid G Protein-coupled Receptors

2004 • 281 citations

A single receptor encoded by vzg-1 / lp _A1 / edg- 2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1998 • 280 citations

Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1

2004 • 275 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3

2001 • 271 citations

Sphingosine 1-Phosphate Analogs as Receptor Antagonists

2004 • 267 citations

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

2002 • 265 citations

Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch

2003 • 263 citations

Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood

2002 • 254 citations

Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid

1999 • 253 citations

Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.

1994 • 253 citations

Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding

2003 • 249 citations

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

2001 • 242 citations

Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3

2002 • 241 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

2000 • 231 citations

Activation‐regulated expression and chemotactic function of sphingosine 1‐phosphate receptors in mouse splenic T cells

2002 • 229 citations

Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

2002 • 228 citations

Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice

2004 • 221 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association with Suppression of Bax

1999 • 219 citations

Sphingosine-1-Phosphate, a Platelet-Derived Lysophospholipid Mediator, Negatively Regulates Cellular Rac Activity and Cell Migration in Vascular Smooth Muscle Cells

2002 • 219 citations

Sphingosine 1-Phosphate Reduces Vascular Leak in Murine and Canine Models of Acute Lung Injury

2004 • 217 citations

Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

2000 • 210 citations

Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction

2002 • 209 citations

In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights

2004 • 207 citations

Functional Comparisons of the Lysophosphatidic Acid Receptors, LP_A1/VZG-1/EDG-2, LP_A2/EDG-4, and LP_A3/EDG-7 in Neuronal Cell Lines Using a Retrovirus Expression System

2000 • 206 citations

Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors

2002 • 201 citations

Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide Production

2001 • 201 citations

Lysophosphatidic acid synthesis and release

2001 • 198 citations

Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

2001 • 191 citations

Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist

2002 • 191 citations

Endothelial cell barrier regulation by sphingosine 1‐phosphate

2004 • 189 citations

Sphingosine 1-phosphate: synthesis and release

2001 • 187 citations

An essential role for the H218/AGR16/Edg‐5/LP_B2 sphingosine 1‐phosphate receptor in neuronal excitability

2001 • 182 citations

Lysophosphatidic acid receptor genevzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain

1998 • 180 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Lysophospholipids and their G protein-coupled receptors in inflammation and immunity

2002 • 179 citations

FTY720: ALTERED LYMPHOCYTE TRAFFIC RESULTS IN ALLOGRAFT PROTECTION

2001 • 175 citations

Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products

2003 • 173 citations

Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors

2002 • 172 citations

Lysophosphatidic Acid (LPA) Is a Novel Extracellular Regulator of Cortical Neuroblast Morphology

2000 • 170 citations

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

2001 • 167 citations

Sphingolipid Mediators in Cardiovascular Cell Biology and Pathology

2001 • 167 citations

Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration

2001 • 166 citations

Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species

1978 • 164 citations

Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate

2000 • 155 citations

Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate

2002 • 154 citations

Edg-6 as a Putative Sphingosine 1-Phosphate Receptor Coupling to Ca2+ Signaling Pathway

2000 • 154 citations

A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs)

1999 • 153 citations

Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate

1999 • 147 citations

Inhibition of Th1- and Th2-Mediated Airway Inflammation by the Sphingosine 1-Phosphate Receptor Agonist FTY720

2003 • 145 citations

A DNA damage and stress inducible G protein-coupled receptor blocks cells in G₂/M

1998 • 144 citations

Potent Immunosuppressants, 2-Alkyl-2-aminopropane-1,3-diols

1996 • 134 citations

Sphingosylphosphorylcholine—biological functions and mechanisms of action

2002 • 132 citations

Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors

2002 • 130 citations

The Lysophospholipid Receptor G2A Activates a Specific Combination of G Proteins and Promotes Apoptosis

2003 • 127 citations

CC Chemokine Receptor 7–dependent and –independent Pathways for Lymphocyte Homing

2001 • 126 citations

The sphingosine 1‐phosphate receptor S1P₄ regulates cell shape and motility via coupling to G_i and G_12/13

2003 • 125 citations

Sphingosine 1-phosphate as a therapeutic agent

2002 • 124 citations

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

2003 • 124 citations

Identification of a Phosphothionate Analogue of Lysophosphatidic Acid (LPA) as a Selective Agonist of the LPA3 Receptor

2003 • 121 citations

Nrg-1 Belongs to the Endothelial Differentiation Gene Family of G Protein-coupled Sphingosine-1-phosphate Receptors

2001 • 121 citations

The Biosynthesis of Phosphatidic Acid and Lysophosphatidic Acid by Glyceride Phosphokinase Pathways in Escherichia coli

1965 • 119 citations

Sphingosine-1-Phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4+ T Cells

2003 • 119 citations

Role of the G-Protein-Coupled Receptor GPR12 as High-Affinity Receptor for Sphingosylphosphorylcholine and Its Expression and Function in Brain Development

2003 • 111 citations

Lysophosphatidylcholine as a ligand for immunoregulation

2002 • 110 citations

A Single Amino Acid Determines Lysophospholipid Specificity of the S1P1 (EDG1) and LPA1 (EDG2) Phospholipid Growth Factor Receptors

2001 • 110 citations

In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice

2002 • 108 citations

Molecular Cloning of the Novel Human G Protein-Coupled Receptor (GPCR) Gene Mapped on Chromosome 9

1996 • 106 citations

Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p₁ in neurogenesis and s1p_1–3 in angiogenesis

2002 • 105 citations

High-Density Lipoprotein Stimulates Myocardial Perfusion In Vivo

2004 • 103 citations

Egress: a receptor‐regulated step in lymphocyte trafficking

2003 • 102 citations

Differential Regulation of Human Lung Epithelial and Endothelial Barrier Function by Thrombin

2004 • 101 citations

Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells

2000 • 101 citations

Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS

2003 • 98 citations

Identification of Human OGR1, a Novel G Protein-Coupled Receptor That Maps to Chromosome 14

1996 • 98 citations

Isolation of Three Novel Human Genes Encoding G Protein-Coupled Receptors

1995 • 97 citations

Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane

2001 • 96 citations

Molecular cloning and characterization of SCaMPER, a sphingolipid Ca2+ release-mediating protein from endoplasmic reticulum.

1996 • 89 citations

A Rational Utilization of High-Throughput Screening Affords Selective, Orally Bioavailable 1-Benzyl-3-carboxyazetidine Sphingosine-1-phosphate-1 Receptor Agonists

2004 • 88 citations

Characterization of the Human and Mouse Sphingosine 1-Phosphate Receptor, S1P₅ (Edg-8): Structure−Activity Relationship of Sphingosine1-Phosphate Receptors

2001 • 86 citations

Mammalian Mg2+-independent Phosphatidate Phosphatase (PAP2) Displays Diacylglycerol Pyrophosphate Phosphatase Activity

1997 • 85 citations

Development of Novel EDG3 Antagonists Using a 3D Database Search and Their Structure−Activity Relationships

2002 • 85 citations

Molecular basis for lysophosphatidic acid receptor antagonist selectivity

2002 • 83 citations

Phospholipase activity in rat liver mitochondria studied by the use of endogenous substrates

1966 • 81 citations

Fatty Alcohol Phosphates are Subtype-Selective Agonists and Antagonists of Lysophosphatidic Acid Receptors

2003 • 80 citations

The Sphingosine-1-Phosphate (S1P) Lysophospholipid Receptor S1P3 Regulates MAdCAM-1+ Endothelial Cells in Splenic Marginal Sinus Organization

2004 • 79 citations

Altered expression and functional profile of lysophosphatidic acid receptors in mitogen‐activated human blood T lymphocytes

2000 • 78 citations

G2A is an oncogenic G protein-coupled receptor

2000 • 78 citations

S1P ₃ ‐mediated Akt activation and crosstalk with platelet‐derived growth factor receptor (PDGFR)

2003 • 75 citations

Lysophospholipids and the cardiovascular system

2002 • 74 citations

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720

2004 • 73 citations

Molecular Cloning, Tissue-Specific Expression, and Chromosomal Localization of a Novel Nerve Growth Factor-Regulated G-Protein-Coupled Receptor, nrg-1

1999 • 73 citations

Lysophosphatidic acid as an autocrine and paracrine mediator

2002 • 72 citations

Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63

2003 • 68 citations

Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement

2000 • 68 citations

Lysophospholipid mediators of immunity and neoplasia

2002 • 65 citations

Complete cDNA Sequence, Genomic Structure, and Chromosomal Localization of the LPA Receptor Gene,lpA1/vzg-1/Gpcr26

1998 • 61 citations

Lysophospholipid regulation of mononuclear phagocytes

2002 • 60 citations

Phytosphingosine 1-phosphate: a high affinity ligand for the S1P4/Edg-6 receptor

2002 • 56 citations

Molecular cloning of a novel putative G protein‐coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system

1993 • 56 citations

Synthesis of Monofluorinated Analogues of Lysophosphatidic Acid

2003 • 56 citations

Isolation of a Novel G Protein-Coupled Receptor (GPR4) Localized to Chromosome 19q13.3

1995 • 49 citations

Lysophosphatidic Acid Induction of Tissue Factor Expression in Aortic Smooth Muscle Cells

2003 • 49 citations

FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines

2001 • 48 citations

Structure–activity relationships of lysophosphatidic acid analogs

2002 • 46 citations

Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists

2004 • 46 citations

Biosynthesis of Phosphatidic Acid from Lysophosphatidic Acid and Palmityl Coenzyme A

1962 • 44 citations

Anti-Cytokine Therapy for the Treatment of Graft-Versus-Host Disease

2004 • 38 citations

RETRACTED: Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila

2002 • 37 citations

Lipid Receptors in Cardiovascular Development

2003 • 37 citations

The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists

2004 • 34 citations

Pharmakologisch wirksame lipoidlösliche säuren in hirnextrakten: Isolierung von lysophosphatidsäure und gangliosid

1961 • 30 citations

Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System

2000 • 30 citations

Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

2004 • 29 citations

Comparative analysis of human and rat S1P5 (edg8): differential expression profiles and sensitivities to antagonists

2002 • 23 citations

An Overall Picture of Chemokine Receptors: Basic Research and Drug Development

2004 • 21 citations

2-Substituted 2-aminoethanol: Minimum essential structure for immunosuppressive activity of ISP-I (Myriocin)

1995 • 20 citations

Sphingosine-1-Phosphate,a Platelet-Derived Lysophospholipid Mediator, Negatively Regulates Cellular Rac Activity and Cell Migration in Vascular Smooth Muscle Cells

2004 • 18 citations

Treatment of Refractory Autoimmune Diseases with Ablative Immunotherapy Using Monoclonal Antibodies and / or High Dose Chemotherapy with Hematopoietic Stem Cell Support

2003 • 18 citations

Tandem genomic arrangement of a G protein (Gna15) and G protein‐coupled receptor (s1p₄/lp_C1/Edg6) gene

2002 • 15 citations