Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers

1998 • 642 citations

Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung

1991 • 594 citations

Lipid second messengers

1994 • 357 citations

Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

2001 • 329 citations

Lysophospholipids activate ovarian and breast cancer cells

1995 • 289 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

Lysophospholipid Growth Factors in the Initiation, Progression, Metastases, and Management of Ovarian Cancer

2000 • 243 citations

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

2001 • 242 citations

Electrospray Ionization Mass Spectrometry Analysis of Lysophospholipids in Human Ascitic Fluids: Comparison of the Lysophospholipid Contents in Malignant vs Nonmalignant Ascitic Fluids

2001 • 234 citations

Characterization of plasma unsaturated lysophosphatidylcholines in human and rat

1999 • 233 citations

Sphingolipid metabolites: Members of a new class of lipid second messengers

1995 • 226 citations

Abnormal Expression of Sphingomyelin Acylase in Atopic Dermatitis: An Etiologic Factor for Ceramide Deficiency?

1996 • 209 citations

Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome

2001 • 204 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation

2001 • 180 citations

Characterization of a human cDNA that encodes a functional receptor for platelet activating factor

1991 • 179 citations

Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism

1999 • 177 citations

EDG3 Is a Functional Receptor Specific for Sphingosine 1-Phosphate and Sphingosylphosphorylcholine with Signaling Characteristics Distinct from EDG1 and AGR16

1999 • 176 citations

Development of Our Current Understanding of Bioactive Lysophospholipids

2000 • 151 citations

Elevated levels and altered fatty acid composition of plasma lysophosphatidlycholine(lysoPC) in ovarian cancer patients

1997 • 148 citations

Induction by Lysophosphatidylcholine, a Major Phospholipid Component of Atherogenic Lipoproteins, of Human Coronary Artery Smooth Muscle Cell Migration

1998 • 128 citations

Characterization of the Phosphorylation Sites Involved in G Protein-coupled Receptor Kinase- and Protein Kinase C-mediated Desensitization of the α1B-Adrenergic Receptor

1997 • 123 citations

Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.

1993 • 117 citations

Lysophospholipids Increase Interleukin-8 Expression in Ovarian Cancer Cells

2001 • 116 citations

Role of lysophosphatidylcholine in the inhibition of endothelial cell motility by oxidized low density lipoprotein.

1996 • 109 citations

Identification of a Putative G Protein-Coupled Receptor Induced during Activation-Induced Apoptosis of T Cells

1996 • 109 citations

Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines

1991 • 109 citations

Identification of Human OGR1, a Novel G Protein-Coupled Receptor That Maps to Chromosome 14

1996 • 98 citations

Sphingosylphosphorylcholine in Niemann-Pick disease brain: accumulation in type A but not in type B.

1999 • 97 citations

Isolation of Three Novel Human Genes Encoding G Protein-Coupled Receptors

1995 • 97 citations

Lysophosphatidyl Choline, a Chemotactic Factor for Monocytes/T-Lymphocytes Is Elevated in Endometriosis

1998 • 96 citations

Effect of lysophosphatidylcholine on transmembrane signal transduction.

1998 • 95 citations

Deletion mapping of two potential chromosome 14 tumor suppressor gene loci in ovarian carcinoma.

1997 • 95 citations

Abnormal serum lysophospholipids in multiple myeloma patients

1999 • 93 citations

Regulation of cell growth by oxidized LDL

2000 • 93 citations

Effect of lysophospholipids on signaling in the human Jurkat T cell line

1995 • 88 citations

G2A is an oncogenic G protein-coupled receptor

2000 • 78 citations

Lysophosphatidylcholine Inhibits Endothelial Cell Migration and Proliferation via Inhibition of the Extracellular Signal–Regulated Kinase Pathway

2000 • 69 citations

Sphingosylphosphorylcholine Induces Endothelial Cell Migration and Morphogenesis

2000 • 68 citations

A New Wound Healing Agent—Sphingosylphosphorylcholine

1996 • 64 citations

Cloning, Characterization, and Mapping of Human Homolog of Mouse T-Cell Death-Associated Gene

1998 • 61 citations

Sphingosylphosphorylcholine Stimulates Proliferation and Upregulates Cell Surface-Associated Plasminogen Activator Activity in Cultured Human Keratinocytes

1998 • 57 citations

Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages

1999 • 56 citations

Immunological mechanisms in atherosclerosis

1995 • 54 citations

Sphingosylphosphorylcholine is a Potent Inducer of Intercellular Adhesion Molecule-1 Expression in Human Keratinocytes

1999 • 51 citations

Sphingosylphosphorylcholine Induces a Hypertrophic Growth Response Through the Mitogen-Activated Protein Kinase Signaling Cascade in Rat Neonatal Cardiac Myocytes

1999 • 49 citations

Lysophosphatidylcholine Promotes Cholesterol Efflux From Mouse Macrophage Foam Cells

1997 • 42 citations

Cloning, sequencing and tissue distribution of two related G protein‐coupled receptor candidates expressed prominently in human lung tissue

1995 • 35 citations

Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine

1988 • 29 citations

Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions

1997 • 25 citations

Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells

1998 • 25 citations

Lysophosphatidic acid modulates alpha(1b)-adrenoceptor phosphorylation and function: roles of Gi and phosphoinositide 3-kinase.

2000 • 25 citations

Molecular Cloning of a Bovine Renal G-Protein Coupled Receptor Gene (bRGR): Regulation of bRGR mRNA Levels by Amino Acid Availability

1997 • 2 citations

Deleted Work

1955 • 0 citations