Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 • 3,295 citations

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

1999 • 3,062 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Calmodulin: a prototypical calcium sensor

2000 • 1,445 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

2001 • 1,385 citations

Molecular interpretation of ERK signal duration by immediate early gene products

2002 • 914 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network

2002 • 647 citations

A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

1996 • 555 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 458 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

An oncogenic role of sphingosine kinase

2000 • 394 citations

NeW Wrinkles for an Old Domain

2000 • 349 citations

Pinning down proline-directed phosphorylation signaling

2002 • 341 citations

PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane

2002 • 293 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases

2002 • 275 citations

Signaling Life and Death in the Thymus: Timing Is Everything

2003 • 255 citations

High Density Lipoproteins (HDL) Interrupt the Sphingosine Kinase Signaling Pathway

1999 • 235 citations

Activation Loop Phosphorylation and Catalysis in Protein Kinases: Is There Functional Evidence for the Autoinhibitor Model?

2002 • 229 citations

Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation

2000 • 186 citations

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

2000 • 177 citations

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

2001 • 167 citations

Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells

2002 • 164 citations

Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells

2001 • 132 citations

Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q2211DNA sequence was deposited in the EMBL database (AJ011304).

2000 • 108 citations

The Nucleotide-binding Site of Human Sphingosine Kinase 1

2002 • 105 citations

IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation

2002 • 103 citations

Sphingosine-1-Phosphate Phosphatases

2001 • 101 citations

Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors

1997 • 99 citations

Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors

2002 • 87 citations

Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity

2002 • 85 citations

Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity

1996 • 78 citations

Grabbing phosphoproteins

1999 • 74 citations

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation

2003 • 60 citations

Cutting edge: extracellular signal-regulated kinase activates syk: a new potential feedback regulation of Fc epsilon receptor signaling.

1999 • 36 citations