SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

Mitochondria and Apoptosis

1998 • 8,909 citations

The versatility and universality of calcium signalling

2000 • 5,407 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

Biologically active sphingolipids in cancer pathogenesis and treatment

2004 • 1,191 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

The complex life of simple sphingolipids

2004 • 624 citations

Discovery and evaluation of inhibitors of human sphingosine kinase.

2003 • 586 citations

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

2003 • 586 citations

Sphingolipidomics: High-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry

2005 • 586 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

2002 • 527 citations

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

2003 • 523 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Radiation and ceramide-induced apoptosis

2003 • 487 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Sphingosine Kinase 2 Is a Nuclear Protein and Inhibits DNA Synthesis

2003 • 407 citations

An oncogenic role of sphingosine kinase

2000 • 394 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis

2003 • 352 citations

Drought-induced guard cell signal transduction involves sphingosine-1-phosphate

2001 • 328 citations

Bax and Bak Promote Apoptosis by Modulating Endoplasmic Reticular and Mitochondrial Ca2+ Stores

2002 • 321 citations

The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE₂production in response to TNF‐α

2003 • 318 citations

The ins and outs of sphingolipid synthesis

2005 • 314 citations

Transactivation of Sphingosine-1–Phosphate Receptors by FcεRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

2004 • 313 citations

Oxygen-bridged Dinuclear Ruthenium Amine Complex Specifically Inhibits Ca2+ Uptake into Mitochondria in Vitroand in Situ in Single Cardiac Myocytes

1998 • 306 citations

PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane

2002 • 293 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors

2003 • 285 citations

Lysophospholipid G Protein-coupled Receptors

2004 • 281 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

Upstream of Growth and Differentiation Factor 1 (uog1), a Mammalian Homolog of the Yeast Longevity Assurance Gene 1 (LAG1), RegulatesN-Stearoyl-sphinganine (C18-(Dihydro)ceramide) Synthesis in a Fumonisin B1-independent Manner in Mammalian Cells

2002 • 280 citations

Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases

2002 • 275 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Point-Counterpoint of Sphingosine 1-Phosphate Metabolism

2004 • 251 citations

Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response

1998 • 244 citations

Sphingosine Kinase Type 1 Promotes Estrogen-Dependent Tumorigenesis of Breast Cancer MCF-7 Cells

2002 • 227 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

2001 • 193 citations

Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2

2003 • 172 citations

Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

2004 • 169 citations

Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis

2002 • 163 citations

Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability

2003 • 161 citations

Sphingosine kinases: A novel family of lipid kinases

2002 • 158 citations

Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor

2005 • 157 citations

Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures

2000 • 155 citations

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase

1997 • 154 citations

BH-3-only BIK Functions at the Endoplasmic Reticulum to Stimulate Cytochrome c Release from Mitochondria

2002 • 152 citations

VEGF receptor expression and signaling in human bladder tumors

2003 • 152 citations

Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis

2004 • 147 citations

Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors

2003 • 147 citations

Sphingosine Kinase 1 (SPHK1) Is Induced by Transforming Growth Factor-β and Mediates TIMP-1 Up-regulation

2004 • 140 citations

Down-regulation of Sphingosine Kinase-1 by DNA Damage

2004 • 129 citations

The Nucleotide-binding Site of Human Sphingosine Kinase 1

2002 • 105 citations

Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

2002 • 98 citations

Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation

2001 • 94 citations

Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert

2004 • 86 citations

cis-4-Methylsphingosine Decreases Sphingolipid Biosynthesis by Specifically Interfering with Serine Palmitoyltransferase Activity in Primary Cultured Neurons

1997 • 76 citations

Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae

2003 • 76 citations

Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region

2003 • 64 citations

Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes

2002 • 40 citations