Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

The emerging role of lysophosphatidic acid in cancer

2003 • 1,086 citations

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

Lysophospholipid Receptors: Signaling and Biology

2004 • 752 citations

Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

2002 • 723 citations

Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 • 719 citations

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.

1992 • 577 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

2005 • 541 citations

Requirement for the lp _A1 lysophosphatidic acid receptor gene in normal suckling behavior

2000 • 468 citations

GPR92 as a New G12/13- and Gq-coupled Lysophosphatidic Acid Receptor That Increases cAMP, LPA5

2006 • 462 citations

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

2004 • 439 citations

Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways

2002 • 413 citations

The Sphingosine-1-phosphate Receptors S1P1, S1P2, and S1P3 Function Coordinately during Embryonic Angiogenesis

2004 • 402 citations

Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

2003 • 392 citations

Characterization of lpa₂ (Edg4) and lpa₁/lpa₂ (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa₂

2002 • 315 citations

Mechanisms of lysophosphatidic acid production

2004 • 293 citations

Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1

2004 • 275 citations

Autotaxin Is Overexpressed in Glioblastoma Multiforme and Contributes to Cell Motility of Glioblastoma by Converting Lysophosphatidylcholine TO Lysophosphatidic Acid

2006 • 238 citations

Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes

2006 • 230 citations

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.

2003 • 223 citations

Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720

2005 • 211 citations

Fgfr2andosteopontindomains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2

1997 • 207 citations

Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor.

2001 • 194 citations

Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells

2000 • 188 citations

Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors

2002 • 172 citations

Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.

2002 • 163 citations

Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization

2001 • 149 citations

Quantitative Measurement of Sphingosine 1-Phosphate in Biological Samples by Acylation with Radioactive Acetic Anhydride

1995 • 118 citations

Autotaxin Expression in Non–Small-Cell Lung Cancer

1999 • 117 citations

Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma

2004 • 114 citations

Expression, regulation and function of autotaxin in thyroid carcinomas

2004 • 109 citations

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

2005 • 108 citations

Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines.

2002 • 103 citations

An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials

2001 • 70 citations

Expression of autotaxin mRNA in human hepatocellular carcinoma.

1999 • 62 citations

A novel colorimetric assay for the determination of lysophosphatidic acid in plasma using an enzymatic cycling method

2003 • 59 citations

VEGF signaling is required for the assembly but not the maintenance of embryonic blood vessels

2002 • 41 citations

[A study on expression of autotaxin mRNA in hepatocellular carcinoma].

1999 • 8 citations