Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Molecular Cloning of the Human Edg2 Protein and Its Identification as a Functional Cellular Receptor for Lysophosphatidic Acid

1997 • 232 citations

Sphingolipid metabolites: Members of a new class of lipid second messengers

1995 • 226 citations

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

1993 • 210 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

The Inducible G Protein-coupled Receptor edg-1 Signals via the Gi/Mitogen-activated Protein Kinase Pathway

1996 • 167 citations

Homophilic Interactions Mediated by Receptor Tyrosine Phosphatases μ and κ. A CRITICAL ROLE FOR THE NOVEL EXTRACELLULAR MAM DOMAIN

1995 • 156 citations

Molecular Cloning of a Novel Putative G Protein-Coupled Receptor Expressed in the Cardiovascular System

1993 • 150 citations

A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes.

1996 • 123 citations

Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis

1995 • 113 citations

Cloning and Characterization of a Putative G-Protein Coupled Receptor Potentially Involved in Development

1994 • 110 citations

Molecular diversity of sphingolipid signalling

1997 • 108 citations

Molecular Cloning of the Novel Human G Protein-Coupled Receptor (GPCR) Gene Mapped on Chromosome 9

1996 • 106 citations

Gi-mediated activation of the Ras/MAP kinase pathway involves a 100kDa tyrosine-phosphorylated Grb2 SH3 binding protein,but not Src nor Shc

1997 • 96 citations

C-terminal Truncation of the Neurokinin-2 Receptor Causes Enhanced and Sustained Agonist-induced Signaling

1995 • 76 citations

Sphingosylphosphorylcholine Activation of Mitogen-activated Protein Kinase in Swiss 3T3 Cells Requires Protein Kinase C and a Pertussis Toxin-sensitive G Protein

1995 • 75 citations

Xenopus oocytes express multiple receptors for LPA-like lipid mediators

1996 • 55 citations

A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.

1996 • 44 citations

Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes

1997 • 42 citations

Cloning and characterization of a new member of the G-protein coupled receptor EDG family.

1995 • 41 citations