Antagonism of Sphingosine-1-Phosphate Receptors by FTY720 Inhibits Angiogenesis and Tumor Vascularization

The biology of VEGF and its receptors

2003 • 9,272 citations

Angiogenesis in health and disease

2003 • 4,127 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Tumor Angiogenesis

1985 • 1,038 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

2000 • 848 citations

VEGF-receptor signal transduction

2003 • 846 citations

Protective Effects of Sphingosine 1-Phosphate in Murine Endotoxin-induced Inflammatory Lung Injury

2004 • 491 citations

A model of angiogenesis in the mouse cornea.

1996 • 411 citations

The Sphingosine-1-phosphate Receptors S1P1, S1P2, and S1P3 Function Coordinately during Embryonic Angiogenesis

2004 • 402 citations

Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability

2003 • 375 citations

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation

2003 • 373 citations

Akt-Mediated Phosphorylation of the G Protein-Coupled Receptor EDG-1 Is Required for Endothelial Cell Chemotaxis

2001 • 284 citations

Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins

2001 • 284 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization

2004 • 265 citations

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

2000 • 231 citations

FTY720, A Novel Immunomodulator: Efficacy and Safety Results from the First Phase 2A Study in de novo Renal Transplantation

2004 • 216 citations

Requirement for sphingosine 1–phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference

2004 • 198 citations

VEGF induces S1P ₁ receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors

2003 • 190 citations

Requirement for sphingosine 1–phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference

2004 • 185 citations

Ligand-induced Trafficking of the Sphingosine-1-phosphate Receptor EDG-1

1999 • 180 citations

Discussion

1999 • 154 citations

Host microenvironment in breast cancer development Inflammatory and immune cells in tumour angiogenesis and arteriogenesis

2003 • 149 citations

Differential Regulation of Sphingosine-1-Phosphate- and VEGF-Induced Endothelial Cell Chemotaxis

2001 • 144 citations

Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin α8β1

2000 • 124 citations

Lipid mediators of angiogenesis and the signalling pathways they initiate

2002 • 72 citations

Positive and Negative Regulation of Angiogenesis: From Cell Biology to the Clinic

1996 • 56 citations

Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.

2003 • 52 citations

Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells

2004 • 21 citations

Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells

2004 • 21 citations

Type‐1 transforming growth factor‐beta differentially modulates tumoricidal activity of murine peritoneal macrophages against metastatic variants of the B16 murine melanoma

2002 • 19 citations