Physiological responses to lysophosphatidic acid and related glycero-phospholipids

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers

1998 • 642 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase

1995 • 547 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

1999 • 411 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

Lysophospholipids activate ovarian and breast cancer cells

1995 • 289 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils

1999 • 240 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing

2000 • 238 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association with Suppression of Bax

1999 • 219 citations

Stimulation of actin stress fibre formation mediated by activation of phospholipase D

1996 • 215 citations

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

1993 • 210 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta

1994 • 195 citations

Induction of in Vitro Tumor Cell Invasion of Cellular Monolayers by Lysophosphatidic Acid or Phospholipase D

1993 • 185 citations

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

1989 • 185 citations

Native and oxidized low‐density lipoproteins have different inhibitory effects on endothelium‐derived relaxing factor in the rabbit aorta

1990 • 183 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux.

1979 • 169 citations

Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. possible involvement of a platelet lipase

1978 • 166 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species

1978 • 164 citations

Induction of Endothelial Cell Chemotaxis by Sphingosine 1-Phosphate and Stabilization of Endothelial Monolayer Barrier Function by Lysophosphatidic Acid, Potential Mediators of Hematopoietic Angiogenesis

1999 • 159 citations

Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway.

1998 • 152 citations

Albumin is a major serum survival factor for renal tubular cells and macrophages through scavenging of ROS

1999 • 152 citations

Lysophosphatidic acid possesses dual action in cellproliferation.

1994 • 151 citations

Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.

1999 • 147 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Neurite‐Protective Effects of Cyclic AMP Signaling

1996 • 137 citations

Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction.

1999 • 133 citations

Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo

2001 • 130 citations

Platelet Aggregation Evoked In Vitro and In Vivo by Phosphatidic Acids and Lysoderivatives: Identity with Substances in Aged Serum (DAS)

1979 • 129 citations

Production of Lysophosphatidic Acids by Lysophospholipase D in Human Follicular Fluids of In Vitro Fertilization Patients1

1999 • 128 citations

Different Roles for RhoA During Neurite Initiation, Elongation, and Regeneration in PC12 Cells

1999 • 126 citations

Naturally Occurring Analogs of Lysophosphatidic Acid Elicit Different Cellular Responses through Selective Activation of Multiple Receptor Subtypes

1998 • 124 citations

Lysophosphatidic acid alters cerebrovascular reactivity in piglets

1995 • 120 citations

Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid

1999 • 119 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Growth factor-like phospholipids generated after corneal injury

1998 • 107 citations

Phosphatidic Acid and Lysophosphatidic Acid Induce Haptotactic Migration of Human Monocytes

1995 • 100 citations

Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells

1999 • 98 citations

A serum factor that activates the phosphatidylinositol phosphate signaling system in Xenopus oocytes.

1990 • 98 citations

Endothelial cell mitogenesis induced by LPA: Inhibition by thrombospondin-1 and thrombospondin-2

1997 • 96 citations

Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: A new group of phospholipid mediators?

1982 • 89 citations

Lysophosphatidic Acid Induction of Transforming Growth Factors α and β: Modulation of Proliferation and Differentiation in Cultured Human Keratinocytes and Mouse Skin

1995 • 87 citations

Exogenous phospholipase D generates Iysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways

1998 • 84 citations

Lysophosphatidic acid-induced aggregation of human and feline platelets: Structure-activity relationship

1981 • 83 citations

Identification of a phosphatidic acid-preferring phospholipase A1 from bovine brain and testis.

1994 • 83 citations

Biochemical Characterization of the Interaction of Lipid Phosphoric Acids with Human Platelets: Comparison with Platelet Activating Factor

1994 • 81 citations

Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA)

1999 • 80 citations

Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acid

1985 • 76 citations

Identification of vasopressor phospholipid in crude soybean lecithin

1978 • 74 citations

MITOGENIC SIGNALING IN ANDROGEN SENSITIVE AND INSENSITIVE PROSTATE CANCER CELL LINES

2000 • 71 citations

rho-mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion

1996 • 70 citations

Platelet-derived lysophosphatidic acid decreases endothelial permeability in vitro

1998 • 68 citations

A factor that activates oscillatory chloride currents in Xenopus oocytes copurifies with a subfraction of serum albumin.

1991 • 65 citations

Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells

1998 • 63 citations

Effect of lysophosphatidic acid on the preimplantation development of mouse embryos

1994 • 58 citations

N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors.

1996 • 57 citations

Xenopus oocytes express multiple receptors for LPA-like lipid mediators

1996 • 55 citations

Quantitative Analysis of Lysophosphatidic Acid in Human Blood Fractions

2000 • 54 citations

Regulation of ET-1 biosynthesis in cerebral microvascular endothelial cells by vasoactive agents and PKC

1999 • 54 citations

Characterization of a Receptor Subtype-Selective Lysophosphatidic Acid Mimetic

1998 • 52 citations

Identification of a Novel Growth Factor-like Lipid, 1-O-cis-Alk-1′-enyl-2-lyso-sn-glycero-3-phosphate (Alkenyl-GP) That Is Present in Commercial Sphingolipid Preparations

1998 • 50 citations

Lysophosphatidic acid potentiates the thrombin-induced production of arachidonate metabolites in platelets.

1981 • 50 citations

�ber die stoffliche Grundlage der Darmbewegungen und des Vagusreizes am Darm

1949 • 45 citations

Actions of Serum and Plasma Albumin on Intracellular Ca²⁺ in Human Endothelial Cells

1997 • 42 citations

Platelet aggregation induced by ether-linked phospholipids. 1. inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor

1987 • 42 citations

Prevention of rat neonatal cardiomyocyte apoptosis induced by simulated in vitro ischemia and reperfusion

1997 • 41 citations

Inhibition of Cell Proliferation by a Unique Lysophosphatidic Acid, PHYLPA, Isolated from Physarum polycephalum: Signaling Events of Antiproliferative Action by PHYLPA.

1993 • 41 citations

The chemical nature of Darmstoff

1957 • 41 citations

Metabolic conversion of the biologically active phospholipid, lysophosphatidic acid, in fibroblasts

1992 • 40 citations

Pharmacologically Active Lipid-Soluble Acids of Natural Occurrence

1957 • 40 citations

Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and on an expressed Drosophila muscarinic receptor

1999 • 40 citations

Effect of lysophosphatidic acid on the ovum transport in mouse oviducts

1999 • 38 citations

Phospholipid Growth Factors and Corneal Wound Healing

2000 • 36 citations

Lysophosphatidic acids: III. Enhancement of neutrophil chemotaxis.

1980 • 36 citations

Cardiovascular effects of lysophosphatidic acid and its structural analogs in rats.

1981 • 34 citations

The effect of active serum albumin on PC12 cells: I. Neurite retraction and activation of the phosphoinositide second messenger system

1992 • 34 citations

Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells.

1999 • 33 citations

Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids

1996 • 30 citations

Vasopressor effect of lysophosphatidic acid on spontaneously hypertensive rats and Wistar Kyoto rats.

1995 • 27 citations

Lysophosphatidic acid, serum, and hyposmolarity activate Cl- currents in corneal keratocytes

1995 • 27 citations

Lysophosphatidic acids. II. Interaction of the effects of adenosine diphosphate and lysophosphatidic acids in dog, rabbit, and human platelets.

1979 • 26 citations

The effect of active serum albumin on PC12 cells: II. Intracellular Ca2+ transients and their role in neurite retraction

1992 • 26 citations

Platelet aggregating activity of lysophosphatidic acids is not related to their calcium ionophore properties

1984 • 23 citations

Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells.

1995 • 22 citations

Pharmacological Characterization of Phospholipid Growth‐Factor Receptors

2000 • 22 citations

Lysophosphatidic Acid and Sphingosine 1‐Phosphate: Two Lipid Villains Provoking Cardiovascular Diseases?

2000 • 22 citations

Lysophosphatidic acid mimics serum‐induced sensitization of cyclic AMP accumulation

1993 • 19 citations

Upregulation of endothelin-1 production by lysophosphatidic acid in rat aortic endothelial cells

1998 • 18 citations

Functional lysophosphatidic acid receptor in bovine luteal cells¹

1997 • 17 citations

Role of lysophosphatidic acid in endothelin-1- and hematoma-induced alteration of cerebral microcirculation

1997 • 16 citations

Topical Application of LPA Accelerates Wound Healing

2000 • 14 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate: Two Lipid Villains Provoking Cardiovascular Diseases?

2000 • 6 citations

Relative importance of diacylglycerol, phosphatidate, lysophosphatidate, inositol trisphosphate and arachidonate metabolism in platelet receptor signalling.

1985 • 3 citations