Non-receptor protein tyrosine kinases

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

The EGFR family and its ligands in human cancer

2001 • 1,554 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

The EGF receptor family as targets for cancer therapy

2000 • 1,339 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

A Road Map for Those Who Don't Know JAK-STAT

2002 • 1,292 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

FAK integrates growth-factor and integrin signals to promote cell migration

2000 • 1,215 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

The importance of being proline: the interaction of proline‐rich motifs in signaling proteins with their cognate domains

2000 • 1,198 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Protein Tyrosine Kinase Structure and Function

2000 • 1,117 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

The protein tyrosine kinase family of the human genome

2000 • 1,107 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

Trk receptors: mediators of neurotrophin action

2001 • 1,051 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases

1995 • 989 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

1999 • 850 citations

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

1994 • 844 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

SH3 domains: complexity in moderation

2001 • 778 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

Paxillin and focal adhesion signalling

2000 • 765 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Myristylation and palmitylation of Src family members: The fats of the matter

1994 • 694 citations

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

1999 • 682 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement

2000 • 661 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Biochemical signals and biological responses elicited by the focal adhesion kinase

2001 • 568 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

1992 • 557 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Differential expression of cellular oncogenes during pre- and postnatal development of the mouse

1982 • 540 citations

Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response

2000 • 537 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1994 • 525 citations

CSK: a protein-tyrosine kinase involved in regulation of src family kinases.

1991 • 522 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Structure and Function of VEGF/VEGF-receptor System Involved in Angiogenesis.

2001 • 508 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

2000 • 473 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

2001 • 463 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

SOCS: physiological suppressors of cytokine signaling

2000 • 457 citations

RAFTK/Pyk2-mediated cellular signalling

2000 • 457 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 454 citations

Janus kinases: components of multiple signaling pathways

2000 • 452 citations

Evidence for In Vivo Phosphorylation of the Grb2 SH2-Domain Binding Site on Focal Adhesion Kinase by Src-Family Protein-Tyrosine Kinases

1996 • 450 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor

1999 • 428 citations

Cooperative Inhibition of T-Cell Antigen Receptor Signaling by a Complex between a Kinase and a Phosphatase

1999 • 427 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

1998 • 426 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

1995 • 425 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis

2000 • 423 citations

Src Tyrosine Kinase Is a Novel Direct Effector of G Proteins

2000 • 422 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

Met receptor tyrosine kinase: enhanced signaling through adapter proteins

2000 • 406 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

Selected glimpses into the activation and function of Src kinase

2000 • 402 citations

Constitutive activation of Src family kinases in mouse embryos that lack Csk

1993 • 401 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

SH2 domains, interaction modules and cellular wiring

2001 • 394 citations

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

1993 • 394 citations

Tyrosine kinase SYK: essential functions for immunoreceptor signalling

2000 • 391 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Initial events of myelination involve Fyn tyrosine kinase signalling

1994 • 383 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

1993 • 374 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor.

1994 • 367 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

1996 • 364 citations

c-Abl kinase regulates the protein binding activity of c-Crk.

1994 • 362 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Matrix Survival Signaling

2000 • 360 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway

1999 • 353 citations

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

1995 • 350 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

Regulation of the Cell Cycle by Focal Adhesion Kinase

1998 • 346 citations

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

2000 • 345 citations

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

1995 • 341 citations

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

1998 • 339 citations

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

1993 • 338 citations

Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes

2000 • 338 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3

2002 • 325 citations

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

1995 • 325 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

2001 • 322 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

1995 • 313 citations

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.

1996 • 312 citations

A Protein Tyrosine Kinase Involved in Regulation of pp60c-src function

1989 • 309 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

1998 • 307 citations

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells

1999 • 307 citations

The B Cell Antigen Receptor Complex: Association of Ig-α and Ig-β with Distinct Cytoplasmic Effectors

1992 • 307 citations

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

2001 • 304 citations

Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

1994 • 304 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.

1994 • 299 citations

Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

1996 • 291 citations

Anti-apoptotic Role of Focal Adhesion Kinase (FAK)

2000 • 291 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

1996 • 286 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

1993 • 283 citations

Autonomous Expression of a Noncatalytic Domain of the Focal Adhesion-Associated Protein Tyrosine Kinase pp125^FAK

1993 • 282 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

Structure and Function of Syk Protein-Tyrosine Kinase

2001 • 280 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration

1999 • 276 citations

Regulatory intramolecular association in a tyrosine kinase of the Tec family

1997 • 274 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

CAKβ/Pyk2 Kinase Is a Signaling Link for Induction of Long-Term Potentiation in CA1 Hippocampus

2001 • 272 citations

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

1993 • 272 citations

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

1993 • 271 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Syk Protein-tyrosine Kinase Is Regulated by Tyrosine-phosphorylated Iga/Ig/3 Immunoreceptor Tyrosine Activation Motif Binding and Autophosphorylation

1995 • 270 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line

1998 • 269 citations

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.

1995 • 264 citations

NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice.

1994 • 263 citations

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

1995 • 261 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1994 • 253 citations

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1999 • 252 citations

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

1995 • 251 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

1998 • 249 citations

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

1994 • 248 citations

PKA Phosphorylation of Src Mediates cAMP's Inhibition of Cell Growth via Rap1

2002 • 245 citations

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

1999 • 245 citations

Autoinhibition of c-Abl

2002 • 244 citations

Closing in on the biological functions of fps/fes and fer

2002 • 240 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled

1989 • 240 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.

1993 • 235 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression

1998 • 234 citations

JAKs, STATs and Src kinases in hematopoiesis

2002 • 234 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.

1994 • 232 citations

Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation.

1993 • 232 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

Phospholipase C-γ1 Interacts with Conserved Phosphotyrosyl Residues in the Linker Region of Syk and Is a Substrate for Syk

1996 • 230 citations

Signaling network of the Btk family kinases

2000 • 230 citations

Association of Focal Adhesion Kinase with Grb7 and Its Role in Cell Migration

1999 • 224 citations

Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

1997 • 224 citations

Structural basis for syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

1998 • 222 citations

Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells

1993 • 222 citations

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking.

1994 • 221 citations

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

1993 • 221 citations

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

1996 • 220 citations

Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.

1993 • 219 citations

Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.

1995 • 218 citations

A JAK1/JAK2 Chimera Can Sustain Alpha and Gamma Interferon Responses

1997 • 216 citations

The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70

1997 • 215 citations

Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.

1994 • 215 citations

Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation

2000 • 215 citations

Structural analysis of receptor tyrosine kinases

1999 • 215 citations

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.

1996 • 214 citations

The Related Adhesion Focal Tyrosine Kinase Is Tyrosine-phosphorylated after β1-Integrin Stimulation in B Cells and Binds to p130cas

1997 • 214 citations

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

1994 • 213 citations

Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins

2001 • 212 citations

A tyrosine kinase profile of prostate carcinoma.

1996 • 212 citations

p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.

1992 • 212 citations

Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

1994 • 209 citations

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.

1993 • 208 citations

Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE

1995 • 207 citations

Role of Jak Kinases and STATs in Cytokine Signal Transduction

2001 • 207 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk

2000 • 206 citations

Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding Capacity

1996 • 203 citations

An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins

1985 • 201 citations

SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

1997 • 201 citations

Identification of the SH2 Domain Binding Protein of Bruton’s Tyrosine Kinase as BLNK—Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling

1999 • 199 citations

Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.

1994 • 198 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

1995 • 196 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Characterization of pp60c-src Tyrosine Kinase Activities Using a Continuous Assay: Autoactivation of the Enzyme Is an Intermolecular Autophosphorylation Process

1995 • 192 citations

Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma 1 and Ras activation

1999 • 192 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor.

1994 • 190 citations

Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation.

1993 • 190 citations

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

1999 • 190 citations

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK.

1993 • 189 citations

Proximal protein tyrosine kinases in immunoreceptor signaling

2001 • 189 citations

B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia.

1994 • 187 citations

Sequence Requirements for Binding of Src Family Tyrosine Kinases to Activated Growth Factor Receptors

1995 • 186 citations

Identification of Tyr-397 as the Primary Site of Tyrosine Phosphorylation and pp60^src Association in the Focal Adhesion Kinase, pp125^FAK

1995 • 185 citations

FAK and PYK2/CAKβ in the nervous system: a link between neuronal activity, plasticity and survival?

1999 • 185 citations

Molecular Biology of the VEGF and the VEGF Receptor Family

2000 • 184 citations

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

1994 • 183 citations

CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities

2001 • 183 citations

Nonreceptor tyrosine protein kinases.

1993 • 183 citations

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1995 • 183 citations

The Focal Adhesion Kinase Suppresses Transformation-associated, Anchorage-independent Apoptosis in Human Breast Cancer Cells

2000 • 182 citations

Focal adhesion kinase promotes phospholipase C-γ1 activity

1999 • 181 citations

Structure of Cdc42 bound to the GTPase binding domain of PAK.

2000 • 180 citations

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes.

1994 • 180 citations

Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase.

1994 • 180 citations

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

1992 • 179 citations

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

1987 • 179 citations

Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif

1994 • 179 citations

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.

1992 • 179 citations

Regulation of the p59^fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase

1992 • 179 citations

Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.

1993 • 179 citations

Differential Intrinsic Enzymatic Activity of Syk and Zap-70 Protein-tyrosine Kinases

1996 • 179 citations

Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

1995 • 179 citations

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

1997 • 178 citations

Regions of the JAK2 Tyrosine Kinase Required for Coupling to the Growth Hormone Receptor

1995 • 176 citations

Interferon-α-dependent Activation of Tyk2 Requires Phosphorylation of Positive Regulatory Tyrosines by Another Kinase

1996 • 176 citations

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

1988 • 176 citations

SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling

1999 • 175 citations

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

1994 • 175 citations

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

1991 • 175 citations

Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line.

1992 • 175 citations

Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

1990 • 173 citations

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.

1994 • 171 citations

c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.

1993 • 170 citations

Syk Expression and Novel Function in a Wide Variety of Tissues

2001 • 170 citations

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.

1994 • 169 citations

Lck Phosphorylates the Activation Loop Tyrosine of the Itk Kinase Domain and Activates Itk Kinase Activity

1997 • 169 citations

Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction

1998 • 168 citations

Glycosphingolipid-enriched Signaling Domain in Mouse Neuroblastoma Neuro2a Cells

1999 • 168 citations

Complexes of Focal Adhesion Kinase (FAK) and Crk-associated Substrate (p130Cas) Are Elevated in Cytoskeleton-associated Fractions following Adhesion and Src Transformation

1997 • 166 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

The Cytoplasmic Tyrosine Kinase FER Is Associated with the Catenin-Like Substrate pp120 and Is Activated by Growth Factors

1995 • 163 citations

Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool

1997 • 163 citations

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours.

1994 • 162 citations

BRK tyrosine kinase expression in a high proportion of human breast carcinomas

1997 • 162 citations

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

1999 • 162 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells.

1994 • 159 citations

Ubiquitin-mediated degradation of active Src tyrosine kinase

1999 • 159 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

Lipopolysaccharide‐induced cytokine production in human monocytes: Role of tyrosine phosphorylation in transmembrane signal transduction

1994 • 158 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

2001 • 157 citations

The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

1990 • 157 citations

p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor.

1994 • 156 citations

Selective Expression of an Endogenous Inhibitor of FAK Regulates Proliferation and Migration of Vascular Smooth Muscle Cells

2001 • 156 citations

Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody.

1988 • 151 citations

Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

1998 • 151 citations

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.

1995 • 151 citations

Syk and Bruton's Tyrosine Kinase Are Required for B Cell Antigen Receptor-mediated Activation of the Kinase Akt

1999 • 150 citations

Specific expression of the human cellular fps/fes-encoded protein NCP92 in normal and leukemic myeloid cells.

1985 • 150 citations

Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

1994 • 148 citations

Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

1994 • 148 citations

The Amino-terminal Portion of the JAK2 Protein Kinase Is Necessary For Binding and Phosphorylation of the Granulocyte-Macrophage Colony-stimulating Factor Receptor β Chain

1995 • 148 citations

Activation of Fes Tyrosine Kinase by gp130, an Interleukin-6 Family Cytokine Signal Transducer, and Their Association

1995 • 147 citations

Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability

2000 • 147 citations

A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor.

1992 • 146 citations

The amino terminus of JAK3 is necessary and sufficient for binding to the common γ chain and confers the ability to transmit interleukin 2-mediated signals

1997 • 146 citations

The Role of Focal Adhesion Kinase Binding in the Regulation of Tyrosine Phosphorylation of Paxillin

1999 • 143 citations

Evidence for a physiological role for membrane rafts in human platelets

2001 • 142 citations

Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking.

1992 • 141 citations

Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation

2000 • 140 citations

Inhibition of Cell Migration by Abl Family Tyrosine Kinases through Uncoupling of Crk-CAS Complexes

2001 • 140 citations

Molecular Characterization of Specific Interactions between SHP-2 Phosphatase and JAK Tyrosine Kinases

1997 • 140 citations

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

1993 • 139 citations

Catalytic Specificity of Phosphotyrosine Kinases Blk, Lyn, c-Src and Syk as Assessed by Phage Display

1996 • 139 citations

Distinct Tyrosine Phosphorylation Sites in ZAP-70 Mediate Activation and Negative Regulation of Antigen Receptor Function

1996 • 139 citations

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine 1 1Edited by I. A. Wilson

1999 • 138 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Identification of a New Pyk2 Isoform Implicated in Chemokine and Antigen Receptor Signaling

1998 • 137 citations

Tyrosine 319, a Newly Identified Phosphorylation Site of ZAP-70, Plays a Critical Role in T Cell Antigen Receptor Signaling

1999 • 137 citations

c-Abl: activation and nuclear targets

2000 • 137 citations

Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)

1998 • 137 citations

Protein-tyrosine Phosphatase α Regulates Src Family Kinases and Alters Cell-Substratum Adhesion

1998 • 137 citations

JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes.

1994 • 136 citations

Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif

1997 • 136 citations

Microdomain-dependent Regulation of Lck and Fyn Protein-Tyrosine Kinases in T Lymphocyte Plasma Membranes

1999 • 136 citations

A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.

1994 • 134 citations

Conservation and Innovation in Plant Signaling Pathways

2000 • 134 citations

Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein.

1985 • 133 citations

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

1995 • 133 citations

Granulocyte-Macrophage Colony-stimulating Factor Stimulates JAK2 Signaling Pathway and Rapidly Activates p93 , STAT1 p91, and STAT3 p92 in Polymorphonuclear Leukocytes

1996 • 133 citations

Syk- and Lyn-Dependent Phosphorylation of Syk on Multiple Tyrosines Following B Cell Activation Includes a Site That Negatively Regulates Signaling

1998 • 133 citations

Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation

1997 • 133 citations

Four Tyrosine Residues in Phospholipase C-γ2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling

2001 • 132 citations

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

1996 • 132 citations

The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation

2001 • 132 citations

BLNK mediates Syk-dependent Btk activation

2001 • 132 citations

Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.

1994 • 132 citations

Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin.

1997 • 129 citations

Phospholipase C-γ2 Couples Bruton's Tyrosine Kinase to the NF-κB Signaling Pathway in B Lymphocytes

2001 • 129 citations

Insights into Src kinase functions: structural comparisons

1998 • 129 citations

Regulation of c-SRC Activity and Function by the Adapter Protein CAS

2000 • 129 citations

Tyrosine 319 in the Interdomain B of ZAP-70 Is a Binding Site for the Src Homology 2 Domain of Lck

1999 • 128 citations

Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

1995 • 127 citations

Brk, a Breast Tumor-derived Non-receptor Protein-tyrosine Kinase, Sensitizes Mammary Epithelial Cells to Epidermal Growth Factor

1996 • 126 citations

The Tyrosine Kinase ACK1 Associates with Clathrin-coated Vesicles through a Binding Motif Shared by Arrestin and Other Adaptors

2001 • 126 citations

The amino-terminal region of Tyk2 sustains the level of interferon α receptor 1, a component of the interferon α/β receptor

1997 • 124 citations

Syk-dependent Phosphorylation of Shc

1996 • 124 citations

Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

2000 • 124 citations

Integrins Regulate the Association and Phosphorylation of Paxillin by c-Abl

1998 • 123 citations

Altered tyrosine 527 phosphorylation and mitotic activation of p60c-src

1991 • 122 citations

Ubiquitin-dependent degradation of active Src

1999 • 122 citations

Involvement of the Tyrosine Kinase Fer in Cell Adhesion

1998 • 122 citations

The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation

2000 • 122 citations

Conformational Changes Induced in the Protein Tyrosine Kinase p72^syk by Tyrosine Phosphorylation or by Binding of Phosphorylated Immunoreceptor Tyrosine-Based Activation Motif Peptides

1996 • 121 citations

Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases

2000 • 120 citations

Covalently bound myristate in a lymphoma tyrosine protein kinase.

1984 • 120 citations

The Nonreceptor Tyrosine Kinase Fer Mediates Cross-Talk between N-Cadherin and β1-Integrins

2000 • 120 citations

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

1997 • 120 citations

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

1996 • 119 citations

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity

1997 • 118 citations

Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain

1999 • 117 citations

Physical association of CD4 with the T cell receptor.

1992 • 116 citations

BRK/Sik expression in the gastrointestinal tract and in colon tumors.

1999 • 114 citations

p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation.

1994 • 114 citations

Src homology 2 domain as a specificity determinant in the c-Abl-mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain.

1995 • 114 citations

Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein

1998 • 113 citations

fyn tyrosine kinase is involved in keratinocyte differentiation control.

1995 • 113 citations

Differential Signaling by the Focal Adhesion Kinase and Cell Adhesion Kinase β

1997 • 113 citations

Differential Effects of Prolactin andsrc/abl Kinases on the Nuclear Translocation of STAT5B and STAT5A

1999 • 113 citations

Physical and functional association of p56lck with Fc gamma RIIIA (CD16) in natural killer cells.

1993 • 113 citations

Coordinate Regulation of Cadherin and Integrin Function by the Chondroitin Sulfate Proteoglycan Neurocan

2000 • 112 citations

The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cδ

1997 • 112 citations

The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin

2001 • 110 citations

Tyrosine Phosphorylation of SLP-76 Is Downstream of Syk following Stimulation of the Collagen Receptor in Platelets

1999 • 110 citations

Association with B‐cell‐antigen receptor with protein‐tyrosine kinase p72^syk and activation by engagement of membrane IgM

1993 • 110 citations

Regulated Expression of Focal Adhesion Kinase-Related Nonkinase, the Autonomously Expressed C-Terminal Domain of Focal Adhesion Kinase

1999 • 109 citations

Stimulation of Fc gamma RIIIA results in phospholipase C-gamma 1 tyrosine phosphorylation and p56lck activation.

1992 • 108 citations

Signal transduction by wild-type and leukemogenic Abl proteins

1997 • 107 citations

The Role of Tec Protein-tyrosine Kinase in T Cell Signaling

1999 • 106 citations

Regulation of Btk by Src Family Tyrosine Kinases

1996 • 106 citations

Increased tyrosine kinase activity of c-Src during calcium-induced keratinocyte differentiation.

1992 • 105 citations

A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

2001 • 104 citations

Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha 12/13

1998 • 104 citations

Cloning and Characterization of a Novel Cdc42-associated Tyrosine Kinase, ACK-2, from Bovine Brain

1997 • 104 citations

The Vav Binding Site (Y315) in ZAP-70 Is Critical for Antigen Receptor–mediated Signal Transduction

1997 • 103 citations

The Adaptor Protein BLNK Is Required for B Cell Antigen Receptor-induced Activation of Nuclear Factor-κB and Cell Cycle Entry and Survival of B Lymphocytes

2001 • 103 citations

Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction.

1997 • 103 citations

Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C.

1988 • 103 citations

The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases.

1992 • 103 citations

The Fps/Fes protein-tyrosine kinase promotes angiogenesis in transgenic mice.

1994 • 102 citations

The Linker Phosphorylation Site Tyr292 Mediates the Negative Regulatory Effect of Cbl on ZAP-70 in T Cells

2000 • 101 citations

Interactions between Two Cytoskeleton-associated Tyrosine Kinases: Calcium-dependent Tyrosine Kinase and Focal Adhesion Tyrosine Kinase

1999 • 101 citations

Fyn and ZAP-70 Are Required for Vav Phosphorylation in T Cells Stimulated by Antigen-presenting Cells

1998 • 101 citations

Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment

1999 • 101 citations

Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor

2001 • 100 citations

Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.

1996 • 100 citations

Activation of c-Src in cells bearing v-Crk and its suppression by Csk.

1992 • 99 citations

Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation

1997 • 98 citations

Ligand discrimination by ErbB receptors: differential signaling through differential phosphorylation site usage

2000 • 98 citations

A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

1993 • 97 citations

cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1.

1988 • 97 citations

p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation.

1992 • 94 citations

Activation of p56^lck by p72^syk through Physical Association and N-Terminal Tyrosine Phosphorylation†

1994 • 94 citations

Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation.

1988 • 94 citations

Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells

1993 • 94 citations

Oligomerization of the Fes Tyrosine Kinase

1997 • 93 citations

Growth Factor-dependent Phosphorylation of the Actin-binding Protein Cortactin Is Mediated by the Cytoplasmic Tyrosine Kinase FER

1998 • 93 citations

Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.

1990 • 93 citations

Tyrosine Phosphorylation of Shc Is Mediated through Lyn and Syk in B Cell Receptor Signaling

1995 • 93 citations

Mice Devoid of Fer Protein-Tyrosine Kinase Activity Are Viable and Fertile but Display Reduced Cortactin Phosphorylation

2001 • 93 citations

Regulation of the Nonreceptor Tyrosine Kinase Brk by Autophosphorylation and by Autoinhibition

2002 • 93 citations

Phosphorylation of c-Src on Tyrosine 527 by Another Protein Tyrosine Kinase

1991 • 92 citations

Locus of inhibitory action of cAMP-dependent protein kinase in the antigen receptor-triggered cytotoxic T lymphocyte activation pathway.

1988 • 92 citations

Identification of Rlk, a Novel Protein Tyrosine Kinase with Predominant Expression in the T Cell Lineage

1995 • 92 citations

The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.

1996 • 92 citations

Human T and B Lymphocytes Express a Structurally Conserved Focal Adhesion Kinase, pp125^FAK

1993 • 91 citations

Tyrosine Residues in Phospholipase Cγ2 Essential for the Enzyme Function in B-cell Signaling

2001 • 91 citations

Modulation of the SH2 Binding Specificity and Kinase Activity of Src by Tyrosine Phosphorylation within Its SH2 Domain

1996 • 91 citations

Enhancement of Lymphocyte Responsiveness by a Gain-of-Function Mutation of ZAP-70

1996 • 91 citations

Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase

2000 • 91 citations

Fibroblast growth factor receptor-1 regulation of Src family kinases.

1995 • 91 citations

Targeting Pyk2 to β1-Integrin–Containing Focal Contacts Rescues Fibronectin-Stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase–Null Cells

2001 • 90 citations

Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.

1995 • 90 citations

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

1993 • 90 citations

Tyrosine kinase signalling in breast cancer: Fibroblast growth factors and their receptors

2000 • 90 citations

Characterization of the Pleckstrin Homology Domain of Btk as an Inositol Polyphosphate and Phosphoinositide Binding Domain

1997 • 89 citations

The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

2000 • 89 citations

Serine Phosphorylation of Focal Adhesion Kinase in Interphase and Mitosis: A Possible Role in Modulating Binding to p130^Cas

2001 • 88 citations

Signals Determining Protein Tyrosine Kinase and Glycosyl-Phosphatidylinositol-Anchored Protein Targeting to a Glycolipid-Enriched Membrane Fraction

1994 • 88 citations

Acquisition of transforming properties by FYN, a normal SRC-related human gene.

1988 • 87 citations

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

1994 • 86 citations

Regulation of the Lck SH2 Domain by Tyrosine Phosphorylation

1996 • 86 citations

Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer

2000 • 86 citations

rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases

1999 • 86 citations

Phosphorylation of serine 59 of p56lck in activated T cells.

1993 • 85 citations

Biochemical identification of a direct physical interaction between the CD4: p56^lck and T_i(TcR)/CD3 complexes

1991 • 85 citations

Targeted disruption of the c-src protooncogene leads to osteopetrosis in mice

1991 • 85 citations

Interaction of the c-fes proto-oncogene product with the interleukin-4 receptor

1994 • 84 citations

The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-golgi network.

1996 • 84 citations

Identification and characterization of a novel tyrosine kinase from megakaryocytes.

1994 • 84 citations

v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts.

1995 • 83 citations

Pyk2 and FAK differentially regulate progression of the cell cycle

2000 • 83 citations

Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

1992 • 82 citations

Redistribution of Glycolipid Raft Domain Components Induces Insulin-Mimetic Signaling in Rat Adipocytes

2001 • 82 citations

Increased fearfulness of Fyn tyrosine kinase deficient mice

1994 • 81 citations

Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium

2001 • 81 citations

Protein-tyrosine Phosphatase PTPεC Inhibits Jak-STAT Signaling and Differentiation Induced by Interleukin-6 and Leukemia Inhibitory Factor in M1 Leukemia Cells

2000 • 81 citations

A Spontaneously Arising Mutation in the DLAARN Motif of Murine ZAP-70 Abrogates Kinase Activity and Arrests Thymocyte Development

1997 • 81 citations

The Cdc42 Target ACK2 Directly Interacts with Clathrin and Influences Clathrin Assembly

2001 • 80 citations

Inhibition of PYK2-induced actin cytoskeleton reorganization, PYK2 autophosphorylation and focal adhesion targeting by FAK

2001 • 80 citations

Triton X-100-resistant membrane complexes from cultured kidney epithelial cells contain the Src family protein tyrosine kinase p62yes.

1994 • 80 citations

TCR/CD3-Induced Activation and Binding of Emt/Itk to Linker of Activated T Cell Complexes: Requirement for the Src Homology 2 Domain

2000 • 80 citations

Activation of the Cdc42-associated Tyrosine Kinase-2 (ACK-2) by Cell Adhesion via Integrin β1

1999 • 80 citations

Functional and physical interaction of protein-tyrosine kinases Fyn and Csk in the T-cell signaling system.

1993 • 80 citations

Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies

2001 • 79 citations

A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract.

1995 • 79 citations

Tec Kinase Signaling in T Cells Is Regulated by Phosphatidylinositol 3-Kinase and the Tec Pleckstrin Homology Domain

2001 • 78 citations

Peptide and Protein Phosphorylation by Protein Tyrosine Kinase Csk: Insights into Specificity and Mechanism

1998 • 78 citations

Activation of src-related tyrosine kinases by IL-3.

1995 • 77 citations

Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK

1996 • 77 citations

Regulation of Calcium-sensitive Tyrosine Kinase Pyk2 by Angiotensin II in Endothelial Cells

2000 • 76 citations

Suppression of Pyk2 Kinase and Cellular Activities by Fip200

2000 • 76 citations

A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling

1998 • 75 citations

Tec protein-tyrosine kinase is involved in interleukin-3 signaling pathway

1995 • 75 citations

Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.

1997 • 73 citations

Constitutive membrane association potentiates activation of Bruton tyrosine kinase

1997 • 73 citations

Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.

1994 • 73 citations

Kinase Activation of the Non-receptor Tyrosine Kinase Etk/BMX Alone Is Sufficient to Transactivate STAT-mediated Gene Expression in Salivary and Lung Epithelial Cells

1999 • 72 citations

The c-Fes Family of Protein-Tyrosine Kinases

1998 • 72 citations

Mutations in the Activation Loop Tyrosines of Protein Tyrosine Kinase Syk Abrogate Intracellular Signaling But Not Kinase Activity

1998 • 71 citations

Abnormal Stat Activation, Hematopoietic Homeostasis, and Innate Immunity in c-fes−/− Mice

2000 • 71 citations

Impairment of Mobility in Endodermal Cells by FAK Deficiency

1996 • 71 citations

Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa

1999 • 71 citations

Autophosphorylation of the Fes Tyrosine Kinase

1996 • 70 citations

Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes.

1994 • 70 citations

Genotoxic Drugs Induce Interaction of the c-Abl Tyrosine Kinase and the Tumor Suppressor Protein p53

1996 • 69 citations

Tyrosine Phosphorylation of RNA Polymerase II Carboxyl-terminal Domain by the Abl-related Gene Product

1997 • 69 citations

Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.

1994 • 68 citations

JAK3 Janus kinase is involved in interleukin 7 signal pathway

1994 • 67 citations

Inhibition of Signaling Through the B Cell Antigen Receptor by the Protooncogene Product, c-Cbl, Requires Syk Tyrosine 317 and the c-Cbl Phosphotyrosine-Binding Domain

1999 • 67 citations

The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells

1999 • 66 citations

SLP-76 Is a Substrate of the High Affinity IgE Receptor-stimulated Protein Tyrosine Kinases in Rat Basophilic Leukemia Cells

1997 • 66 citations

Evidence that phospholipase C‐γ2 interacts with SLP‐76, Syk, Lyn, LAT and the Fc receptor γ‐chain after stimulation of the collagen receptor glycoprotein VI in human platelets

1999 • 65 citations

Enhanced Endotoxin Sensitivity in Fps/Fes-Null Mice with Minimal Defects in Hematopoietic Homeostasis

2002 • 64 citations

Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor

2000 • 64 citations

Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.

1999 • 64 citations

Pre-T Cell Receptor Signals Are Responsible for the Down-Regulation of Syk Protein Tyrosine Kinase Expression

1999 • 64 citations

Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase

2000 • 63 citations

Domain Interactions in Protein Tyrosine Kinase Csk

1999 • 63 citations

Rho and Rho-associated Kinase Modulate the Tyrosine Kinase PYK2 in T-cells through Regulation of the Activity of the Integrin LFA-1

2001 • 63 citations

Inhibition of the Catalytic Activity of Cell Adhesion Kinase β by Protein-tyrosine Phosphatase-PEST-mediated Dephosphorylation

2001 • 62 citations

Complex Formation of JAK2 with PP2A, PI3K, and Yes in Response to the Hematopoietic Cytokine Interleukin-11

1996 • 62 citations

Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells.

1996 • 61 citations

Tyrosine kinase gene expression in the mouse small intestine.

1994 • 61 citations

Activation of the Guanine Nucleotide Exchange Factor Dbl Following ACK1-Dependent Tyrosine Phosphorylation

2000 • 61 citations

PYK2 Links Gqα and G13α Signaling to NF-κB Activation

2001 • 61 citations

Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes.

1999 • 60 citations

Fer Kinase Is Required for Sustained p38 Kinase Activation and Maximal Chemotaxis of Activated Mast Cells

2002 • 60 citations

Cloning of FRK, a novel human intracellular SRC-like tyrosine kinaseencoding gene

1994 • 60 citations

Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells.

1993 • 60 citations

Mapping of multiple phosphorylation sites within the structural and catalytic domains of the Fujinami avian sarcoma virus transforming protein

1983 • 59 citations

Mutagenic Analysis of the Roles of SH2 and SH3 Domains in Regulation of the Abl Tyrosine Kinase

1994 • 59 citations

Activation of the protein tyrosine kinase tyk2 by interferon α/β

1994 • 59 citations

Tyrosine phosphorylation of ACK in response to temperature shift‐down, hyperosmotic shock, and epidermal growth factor stimulation

1996 • 59 citations

Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation.

1994 • 59 citations

Point Mutation of a Tyrosine in the Linker Region of Syk Results in a Gain of Function

2000 • 59 citations

G-CSF Induces Tyrosine Phosphorylation of the JAK2 Protein in the Human Myeloid G-CSF Responsive and Proliferative Cells, but Not in Mature Neutrophils

1994 • 58 citations

Purification and Characterization of Human ZAP-70 Protein-tyrosine Kinase from a Baculovirus Expression System

1996 • 58 citations

Tec protein‐tyrosine kinase is an effector molecule of Lyn proteni‐tyroenie kinase

1996 • 58 citations

Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells

2000 • 58 citations

Targeted Disruption of the Murine fps/fes Proto-Oncogene Reveals that Fps/Fes Kinase Activity Is Dispensable for Hematopoiesis

1999 • 57 citations

Restoration of Thymocyte Development and Function in zap-70−/− Mice by the Syk Protein Tyrosine Kinase

1997 • 57 citations

Inhibition of human B cell activation by diterpine forskolin: interference with B cell growth factor-induced G1 to S transition of the B cell cycle.

1984 • 57 citations

Myristylation Is Required for Tyr-527 Dephosphorylation and Activation of pp60^c-src in Mitosis

1993 • 57 citations

In Vivo and In Vitro Specificity of Protein Tyrosine Kinases for Immunoglobulin G Receptor (FcγRII) Phosphorylation

1996 • 56 citations

Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: Detection of associated proteins at 72 and 120–130 kD

1992 • 56 citations

Drosophila Ack Targets Its Substrate, the Sorting Nexin DSH3PX1, to a Protein Complex Involved in Axonal Guidance

2002 • 56 citations

Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.

1994 • 55 citations

Autophosphorylation Induces Autoactivation and a Decrease in the Src Homology 2 Domain Accessibility of the Lyn Protein Kinase

1995 • 55 citations

Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713).

1993 • 55 citations

Src autoinhibition: let us count the ways.

1999 • 55 citations

A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues.

1993 • 54 citations

Src Activity Increases and Yes Activity Decreases during Mitosis of Human Colon Carcinoma Cells

1995 • 54 citations

Translocation of tyrosine-phosphorylated TCRζ chain to glycolipid-enriched membrane domains upon T cell activation

1999 • 54 citations

Localization and modulation of ErbB receptor tyrosine kinases

2001 • 54 citations

ABL mechanisms of regulation and activation

2002 • 54 citations

Nuclear and Cytoplasmic Location of the FER Tyrosine Kinase

1991 • 53 citations

c-fes expression in ontogenetic development and hematopoietic differentiation.

1994 • 53 citations

Effects of SH2 and SH3 Deletions on the Functional Activities of Wild-Type and Transforming Variants of c-Src

1992 • 53 citations

Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain

2001 • 53 citations

Disruption of Coiled-coil Domains in Fer Protein-tyrosine Kinase Abolishes Trimerization but Not Kinase Activation

1999 • 53 citations

Characterization of the Tyrosine Kinases RAFTK/Pyk2 and FAK in Nerve Growth Factor-induced Neuronal Differentiation

2000 • 53 citations

A Point Mutation in the N-Terminal Coiled-Coil Domain Releases c-Fes Tyrosine Kinase Activity and Survival Signaling in Myeloid Leukemia Cells

2001 • 53 citations

The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding

1997 • 53 citations

Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation

1997 • 52 citations

Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro.

1995 • 52 citations

Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk

1997 • 51 citations

Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells.

1993 • 51 citations

Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes.

1994 • 51 citations

Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase

1996 • 51 citations

Stimulation of M3 Muscarinic Receptors Induces Phosphorylation of the Cdc42 Effector Activated Cdc42Hs-associated Kinase-1 via a Fyn Tyrosine Kinase Signaling Pathway

2001 • 51 citations

Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.

1992 • 51 citations

Brain armadillo protein δ‐catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors

2002 • 50 citations

Association of the p56lck protein tyrosine kinase with the FCγRIIIA/CD16 complex in human natural killer cells

1993 • 50 citations

The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.

1995 • 49 citations

Nuclear protein tyrosine kinases

1994 • 49 citations

Epidermal Growth Factor Stimulation of the ACK1/Dbl Pathway in a Cdc42 and Grb2-Dependent Manner

2001 • 48 citations

Dysregulated Myelopoiesis in Mice Lacking Jak3

1999 • 48 citations

A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption.

1994 • 48 citations

Cyclic AMP has the ability to influence multiple events during B cell stimulation

1988 • 48 citations

The Fes Protein-Tyrosine Kinase Phosphorylates a Subset of Macrophage Proteins That Are Involved in Cell Adhesion and Cell-Cell Signaling

1997 • 47 citations

Reconstitution of T Cell Antigen Receptor‐Induced Erk2 Kinase Activation in Lck‐Negative JCaM1 Cells by Syk

1997 • 47 citations

Stimulation of Ras Guanine Nucleotide Exchange Activity of Ras-GRF1/CDC25Mm upon Tyrosine Phosphorylation by the Cdc42-regulated Kinase ACK1

2000 • 47 citations

Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase

1992 • 47 citations

Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines.

1988 • 47 citations

Subcellular Localization Analysis of the Closely Related Fps/Fes and Fer Protein-Tyrosine Kinases Suggests a Distinct Role for Fps/Fes in Vesicular Trafficking

2001 • 46 citations

Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.

1993 • 46 citations

Allo‐skin graft rejection, tumor rejection and natural killer activity in mice lacking p56^lck

1995 • 45 citations

Tec and Jak2 Kinases Cooperate to Mediate Cytokine-Driven Activation of c-fos Transcription

1998 • 45 citations

Interaction of p59fynwith Interferon-Activated Jak Kinases

1997 • 45 citations

Identification of the Site in the Syk Protein Tyrosine Kinase That Binds the SH2 Domain of Lck

1996 • 44 citations

Phosphatidylinositol 3-Kinase Is Required for CD28 But Not CD3 Regulation of the TEC Family Tyrosine Kinase EMT/ITK/TSK: Functional and Physical Interaction of EMT with Phosphatidylinositol 3-Kinase

1998 • 44 citations

Intermolecular interactions between the SH3 domain and the proline‐rich TH region of Bruton's tyrosine kinase

2001 • 44 citations

The Solution Structure and Intramolecular Associations of the Tec Kinase Src Homology 3 Domain

2002 • 44 citations

Competing modes of self‐association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

2002 • 44 citations

Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.

1993 • 44 citations

Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell Fc∊RI Engagement

1995 • 43 citations

Hematopoietic Cell Phosphatase (HCP) Regulates p56LCKPhosphorylation and ZAP-70 Binding to T Cell Receptor ζ Chain

1996 • 43 citations

Murine txk: a protein tyrosine kinase gene regulated by T cell activation.

1995 • 43 citations

Comparative study of three protein-tyrosine phosphatases. Chicken protein-tyrosine phosphatase lambda dephosphorylates c-Src tyrosine 527.

1994 • 43 citations

T Cell Activation Induced by Novel Gain-of-function Mutants of Syk and ZAP-70

1998 • 43 citations

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase

2000 • 42 citations

SH2 domains: From structure to energetics, a dual approach to the study of structure-function relationships

1999 • 42 citations

The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner

2000 • 42 citations

The src family of tyrosine protein kinases in hemopoietic signal transduction

1993 • 42 citations

Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.

1992 • 41 citations

c-ABL Tyrosine Kinase Activity Is Regulated by Association with a Novel SH3-Domain-Binding Protein

1996 • 41 citations

Absence of Fer Protein-Tyrosine Kinase Exacerbates Leukocyte Recruitment in Response to Endotoxin

2002 • 41 citations

Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway

1999 • 41 citations

Interdomain B in ZAP-70 Regulates but Is Not Required for ZAP-70 Signaling Function in Lymphocytes

1999 • 41 citations

Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.

1993 • 41 citations

Syk: a new player in the field of breast cancer

2000 • 40 citations

GTK, a Src-related Tyrosine Kinase, Induces Nerve Growth Factor-independent Neurite Outgrowth in PC12 Cells through Activation of the Rap1 Pathway

2000 • 40 citations

Analysis of CSK Homologous Kinase (CHK/HYL) in Hematopoiesis by Utilizing Gene Knockout Mice

1996 • 40 citations

Molecular Cloning of Rodent p72Syk.

1995 • 40 citations

The Angiotensin II–Dependent Association of Jak2 and c-Src Requires the N-Terminus of Jak2 and the SH2 Domain of c-Src

1999 • 40 citations

Integrin‐mediated signal transduction in cells lacking focal adhesion kinase p125^FAK

1998 • 40 citations

Exon-Intron Structure of the Human PTK6 Gene Demonstrates That PTK6 Constitutes a Distinct Family of Non-Receptor Tyrosine Kinase1

1998 • 40 citations

Chk, a Csk Family Tyrosine Protein Kinase, Exhibits Csk-like Activity in Fibroblasts, but Not in an Antigen-specific T-cell Line

1997 • 40 citations

Regulation of Zap-70 by Src Family Tyrosine Protein Kinases in an Antigen-specific T-cell Line

1995 • 39 citations

Phosphorylation of a Src Kinase at the Autophosphorylation Site in the Absence of Src Kinase Activity

2000 • 39 citations

Arg encodes a widely expressed 145 kDa protein-tyrosine kinase.

1991 • 39 citations

Cellular localization of c-fps gene product NCP98

1984 • 38 citations

Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets

1998 • 38 citations

Subcellular localization of the Arg protein tyrosine kinase.

1996 • 38 citations

Characterization of Mice Deficient in the Src Family Nonreceptor Tyrosine Kinase Frk/rak

2002 • 37 citations

Nuclear and cytoplasmic location of the FER tyrosine kinase.

1991 • 37 citations

The Src homology 2 domain of the protein-tyrosine kinase p56lck mediates both intermolecular and intramolecular interactions.

1993 • 36 citations

Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene.

1994 • 36 citations

Cell cycle-dependent nuclear accumulation of the p94fer tyrosine kinase is regulated by its NH2 terminus and is affected by kinase domain integrity and ATP binding.

1999 • 36 citations

Analysis of the sites in p56lck whose phosphorylation is induced by tetradecanoyl phorbol acetate.

1990 • 35 citations

Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase.

1995 • 35 citations

Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction.

1994 • 34 citations

Role of Tyr518 and Tyr519 in the Regulation of Catalytic Activity and Substrate Phosphorylation by Syk Protein-Tyrosine Kinase

1997 • 33 citations

Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin α (Rch1α)

2001 • 33 citations

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

2002 • 33 citations

The Nonreceptor Tyrosine Kinase ACK2, a Specific Target for Cdc42 and a Negative Regulator of Cell Growth and Focal Adhesion Complexes

2001 • 33 citations

Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms.

1988 • 33 citations

Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes

2000 • 33 citations

Src family tyrosine kinase Lyn binds several proteins including paxillin in rat basophilic leukemia cells

1994 • 33 citations

Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution

1995 • 32 citations

Herbimycin A inhibits the association of p60v-src with the cytoskeletal structure and with phosphatidylinositol 3' kinase.

1993 • 32 citations

IYK, A Novel Intracellular Protein Tyrosine Kinase Differentially Expressed in the Mouse Mammary Gland and Intestine

1995 • 31 citations

Members of the src family of nonreceptor tyrosine kinases share a common mechanism for membrane binding.

1993 • 31 citations

Mediation by the Protein-tyrosine Kinase Tec of Signaling between the B Cell Antigen Receptor and Dok-1

2000 • 31 citations

Activation of Zap-70 Tyrosine Kinase Due to a Structural Rearrangement Induced by Tyrosine Phosphorylation and/or ITAM Binding

2000 • 31 citations

Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.

1996 • 30 citations

Human c-FES is a nuclear tyrosine kinase.

1995 • 30 citations

Activation of c-Src in Cells Bearing v-Crk and Its Suppression by Csk

1992 • 29 citations

Src regulated by C-terminal phosphorylation is monomeric

1997 • 29 citations

Increased sensitivity to apoptotic stimuli in c-abl-deficient progenitor B-cell lines

1996 • 28 citations

Characterization of the Roles of SH2 Domain-Containing Proteins in T-Lymphocyte Activation by Using Dominant Negative SH2 Domains

1996 • 28 citations

Accessibility of the c-Src SH2-domain for binding is increased during mitosis.

1994 • 27 citations

ACK Family Tyrosine Kinase Activity Is a Component of Dcdc42 Signaling during Dorsal Closure in Drosophila melanogaster

2002 • 26 citations

IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59

1994 • 26 citations

Protein-tyrosine kinase activity tightly associated with human type II Fc gamma receptors.

1994 • 26 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibition in a rat mast cell line. Impairment of tyrosine kinase-dependent signal transduction and the subsequent degranulation response

1993 • 25 citations

Focal Adhesion Kinase pp125FAKand the β1 Integrin Subunit Are Constitutively Complexed in HaCaT Cells

1998 • 25 citations

Negative Regulation of Janus Kinases

2001 • 23 citations

The Fps/Fes Protein-Tyrosine Kinase Promotes Angiogenesis in Transgenic Mice

1994 • 22 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 21 citations

Mutation of C-Terminal Tyrosine Residues Y497/Y504 of the Src-Family Member Bsk/Iyk Decreases NIH3T3 Cell Proliferation

1998 • 21 citations

A Novel Nonreceptor Tyrosine Kinase, Srm: Cloning and Targeted Disruption

1994 • 20 citations

Deletion of Src Homology 3 Domain Results in Constitutive Activation of Tec Protein‐Tyrosine Kinase

1996 • 20 citations

Nonmyristoylated Abl Proteins Transform a Factor-Dependent Hematopoietic Cell Line

1992 • 19 citations

In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts.

1990 • 17 citations

Characterization of the Tyrosine Kinase Tnk1 and Its Binding with Phospholipase C-γ1

2000 • 17 citations

Src homology 2 domain substitution modulates the kinase and transforming activities of the Fes protein-tyrosine kinase.

2000 • 16 citations

Integrin-Dependent Tyrosine Phoshorylation and Cytoskeletal Translocation of Tec in Thrombin-Activated Platelets

1997 • 16 citations

The apical membranes of maturing gut columnar epithelial cells contain the enzymatically active form of a newly identified fyn-related tyrosine kinase.

1996 • 15 citations

Role of the Bsk/Iyk Non-Receptor Tyrosine Kinase for the Control of Growth and Hormone Production in RINm5F Cells

2000 • 15 citations

Myristylation and amino-terminal phosphorylation are required for activation of pp60c-src during mitosis.

1993 • 15 citations

Effect of the mutation of tyrosine 713 in p93c-fes on its catalytic activity and ability to promote myeloid differentiation in K562 cells

1993 • 14 citations

Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene.

1996 • 14 citations

Truncation of c-fes via Gene Targeting Results in Embryonic Lethality and Hyperproliferation of Hematopoietic Cells

2002 • 14 citations

Diminished tyrosine protein kinase activity in T cells unresponsive to TCR stimulation

1994 • 13 citations

DEFICIENT EXPRESSION OF A B CELL CYTOPLASMIC TYROSINE KINASE IN HUMAN X-LINKED AGAMMAGLOBULINEMIA

1994 • 12 citations

Association with B-cell-antigen receptor with protein-tyrosine kinase p72[syk] and activation by engagement of membrane IgM

1994 • 11 citations

The effects of cyclic nucleotides on the proliferation of cultured human T-lymphocytes

1984 • 10 citations

Regulation of SRC-family protein tyrosine kinases by interleukins, IL-2, and IL-3.

1992 • 9 citations

Role of the Src homology 2 domains and interdomain regions in ZAP‐70 phosphorylation and enzymatic activity

1999 • 9 citations

Epidermal growth factor stimulates a protein tyrosine kinase which is separable from the epidermal growth factor receptor.

1993 • 8 citations

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

1996 • 7 citations

Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases

2000 • 7 citations

The Focal Adhesion Kinase Suppresses Transformation-associated, Anchorage-independent Apoptosis in Human Breast Cancer Cells: INVOLVEMENT OF DEATH RECEPTOR-RELATED SIGNALING PATHWAYS

2000 • 7 citations

Tec protein-tyrosine kinase is involved in interleukin-3 signaling pathway

1995 • 6 citations

Interleukin-3–Induced Activation of the JAK/STAT Pathway Is Prolonged by Proteasome Inhibitors

1998 • 5 citations

Construction of a Cell‐Permeable CDC42 Binding Fragment of ACK That Inhibits v‐Ha‐Ras Transformation

1999 • 5 citations

Tec and Jak2 Kinases Cooperate to Mediate Cytokine-Driven Activation of c-fos Transcription

1998 • 5 citations

Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells

1993 • 5 citations

Interactions between Two Cytoskeleton-associated Tyrosine Kinases: Calcium-dependent Tyrosine Kinase and Focal Adhesion Tyrosine Kinase

1999 • 5 citations

Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase

2000 • 5 citations

Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway

1999 • 4 citations

The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase.

2000 • 3 citations

Tec Protein-Tyrosine Kinase is an Effector Molecule of Lyn Protein-Tyrosine Kinase

1997 • 3 citations

Characterization of Mice Deficient in the Src Family Nonreceptor Tyrosine Kinase Frk/rak

2002 • 2 citations

IYK, a Novel Intracellular Protein Tyrosine Kinase Differentially Expressed in the Mouse Mammary Gland and Intestine

1995 • 2 citations

Deletion of Src Homology 3 Domain Results in Constitutive Activation of Tec Protein-Tyrosine Kinase

1997 • 1 citations