Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

NF-kappa B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

1999 • 554 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

I kappa B epsilon, a novel member of the Ikappa B family, controls RelA and cRel NF-kappa B activity

1997 • 394 citations

IκB proteins: structure, function and regulation

1997 • 330 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Phosphatidylinositol 3-Kinase-dependent Membrane Association of the Bruton's Tyrosine Kinase Pleckstrin Homology Domain Visualized in Single Living Cells

1999 • 291 citations

Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production

1998 • 249 citations

CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-κB and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-κB-inducing Kinase

1998 • 239 citations

The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages

1993 • 206 citations

Identification of the SH2 Domain Binding Protein of Bruton’s Tyrosine Kinase as BLNK—Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling

1999 • 199 citations

The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

1998 • 198 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

Molecular mechanisms in B cell antigen receptor signaling

1997 • 194 citations

Induction of the transcription factors NF-кB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

1995 • 192 citations

B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia.

1994 • 187 citations

BAP-135, a target for Bruton’s tyrosine kinase in response to B cell receptor engagement

1997 • 182 citations

BTKbase, mutation database for X-linked agammaglobulinemia (XLA)

1998 • 155 citations

B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.

1995 • 149 citations

The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function

1995 • 139 citations

The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.

1995 • 131 citations

Protein Kinase C μ (PKCμ) Associates with the B Cell Antigen Receptor Complex and Regulates Lymphocyte Signaling

1996 • 130 citations

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis.

1996 • 117 citations

Regulation of Nuclear Localization and Transcriptional Activity of TFII-I by Bruton’s Tyrosine Kinase

1999 • 110 citations

Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway

1999 • 108 citations

Bruton's Tyrosine Kinase is a Key Regulator in B‐Cell Development

1994 • 107 citations

Bruton's Tyrosine Kinase Controls a Sustained Calcium Signal Essential for B Lineage Development and Function

1999 • 105 citations

Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptor.

1991 • 103 citations

Maintenance of nuclear factor-kappa B/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins.

1996 • 97 citations

Characterization of CD40 signaling determinants regulating nuclear factor-kappa B activation in B lymphocytes.

1997 • 97 citations

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.

1995 • 93 citations

CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regulator of CD38 induced signal transduction

1995 • 87 citations

X‐Linked Agammaglobulinemia: New Approaches to Old Questions based on the Identification of the Defective Gene

1994 • 86 citations

The SH3 Domain of Bruton's Tyrosine Kinase Interacts with Vav, Sam68 and EWS

1997 • 76 citations

Transgene Expression of bcl-xL Permits Anti-immunoglobulin (Ig)–induced Proliferation in xid B Cells

1998 • 74 citations

Constitutive membrane association potentiates activation of Bruton tyrosine kinase

1997 • 73 citations

Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement.

1997 • 72 citations

The Ability of CD40L, but Not Lipopolysaccharide, To Initiate Immunoglobulin Switching to Immunoglobulin G1 Is Explained by Differential Induction of NF-κB/Rel Proteins

1998 • 67 citations

An intact NF-κB signaling pathway is required for maintenance of mature B cell subsets

1999 • 67 citations

The SH2 Domain-containing Inositol 5′-Phosphatase (SHIP) Recruits the p85 Subunit of Phosphoinositide 3-Kinase during FcγRIIb1-mediated Inhibition of B Cell Receptor Signaling

1999 • 64 citations

xid affects events leading to B cell cycle entry.

1997 • 61 citations

An NFAT-Dependent Enhancer Is Necessary for Anti-IgM-Mediated Induction of Murine CD5 Expression in Primary Splenic B Cells

1998 • 59 citations

Developmental regulation of dendritic cell function

1999 • 57 citations

rel/NF-kappa B nuclear complexes that bind kB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells.

1993 • 55 citations

Activation and proliferation signals in mouse B cells I. A comparison of the capacity of anti‐Ig antibodies or phorbol myristic acetate to activate B cells from CBA/N or normal mice into G₁

1984 • 52 citations

Defective IL-5-receptor-mediated signaling in B cells of X-linked immunodeficient mice

1995 • 52 citations

Intracellular signaling for inducible antigen receptor-mediated Fas resistance in B cells.

1996 • 52 citations

Bruton's tyrosine kinase (Btk) associates with protein kinase C μ

1999 • 47 citations

Defective degranulation and calcium mobilization of bone-marrow derived mast cells from Xid and Btk-deficient mice

1998 • 43 citations

All three IκB isoforms and most Rel family members are stably associated with the IκB kinase 1/2 complex

1999 • 43 citations

Accelerated Emigration of B Lymphocytes in the Xid Mouse

1999 • 38 citations

Receptor-specific induction of NF-kappaB components in primary B cells

1998 • 38 citations

Syk Is Required for BCR-mediated Activation of p90Rsk, but Not p70S6k, via a Mitogen-activated Protein Kinase-independent Pathway in B Cells

1997 • 36 citations

BTKbase, mutation database for X-linked agammaglobulinemia (XLA)

1997 • 36 citations

Activation and regulation of the IκB kinase in human B cells by CD40 signaling

1999 • 35 citations

Differential activation and regulation of mitogen-activated protein kinases through the antigen receptor and CD40 in human B cells

1999 • 32 citations

Differential regulation of c-Rel translocation in activated B and T cells.

1996 • 32 citations

A re‐evaluation of the effects of X‐linked immunodeficiency (xid) mutation on B cell differentiation and function in the mouse

1997 • 32 citations

Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin

1995 • 31 citations

An 11-amino acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun N-terminal kinase, activation of MAPKAP kinase-2, phosphorylation of I kappa B alpha, and protection of WEHI-231 cells from anti-IgM-induced growth arrest.

1999 • 30 citations

An 11-Amino Acid Sequence in the Cytoplasmic Domain of CD40 Is Sufficient for Activation of c-Jun N-Terminal Kinase, Activation of MAPKAP Kinase-2, Phosphorylation of IκBα, and Protection of WEHI-231 Cells from Anti-IgM-Induced Growth Arrest

1999 • 28 citations

Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene.

1991 • 26 citations

Biochemical analysis of the immune B cell defect in xid mice.

1991 • 26 citations

Synergistic genetic defect in B-lymphocyte function. I. Defective responses to B-cell stimulants and their genetic basis.

1980 • 22 citations

Deleted Work

1955 • 0 citations