Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Protein kinase activity associated with the avian sarcoma virus src gene product.

1978 • 1,137 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Identification of a transformation-specific antigen induced by an avian sarcoma virus

1977 • 931 citations

Nucleotide sequence of rous sarcoma virus

1983 • 901 citations

Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines.

1979 • 759 citations

Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein

1978 • 673 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

1981 • 440 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product

1980 • 420 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).

1981 • 363 citations

Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.

1982 • 337 citations

Transformation by Rous sarcoma virus: A cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine

1980 • 328 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus

1983 • 225 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Low Level of Cellular Protein Phosphorylation by Nontransforming Overproduced p60^c-src

1985 • 176 citations

Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein.

1986 • 171 citations

Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin

1984 • 163 citations

Activation of the transforming potential of p60c-src by a single amino acid change.

1986 • 161 citations

Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

1984 • 161 citations

Changes in Protein Phosphorylation in Rous Sarcoma Virus-Transformed Chicken Embryo Cells

1981 • 158 citations

Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen.

1986 • 147 citations

Characterization of cDNA clones for the human c-yes gene.

1987 • 147 citations

Restriction of the In Vitro and In Vivo Tyrosine Protein Kinase Activities of pp60^c-src Relative to pp60^v-src

1985 • 119 citations

Isolation and Oncogenic Potential of a Novel Human src-Like Gene

1986 • 113 citations

Location of the c- yes Gene on the Human Chromosome and Its Expression in Various Tissues

1985 • 89 citations

Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation

1982 • 83 citations

Structure, expression, and chromosomal location of the human c-fgr gene.

1986 • 81 citations

Dephosphorylation or Antibody Binding to the Carboxy Terminus Stimulates pp60^c-src

1986 • 80 citations

Isolation of Duplicated Human c-src Genes Located on Chromosomes 1 and 20

1985 • 78 citations

Development of Anti-pp60 ^src Serum with Antigen Produced in Escherichia coli

1983 • 75 citations

Amino Acid Alterations Within a Highly Conserved Region of the Rous Sarcoma Virus src Gene Product pp60^src Inactivate Tyrosine Protein Kinase Activity

1984 • 75 citations

Phosphotyrosine-containing proteins and expression of transformation parameters in cells infected with partial transformation mutants of Rous sarcoma virus

1983 • 62 citations

Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation

1985 • 53 citations

Altered Sites of Tyrosine Phosphorylation in pp60^c-src Associated with Polyomavirus Middle Tumor Antigen

1986 • 48 citations

Phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide of pp60c-src.

1986 • 45 citations

Characterization of cDNA Clones for the Human c-yes Gene

1987 • 38 citations

Structure, Expression, and Chromosomal Location of the Human c-fgr Gene

1986 • 19 citations