Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

1990 • 432 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

1991 • 391 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Sequence requirements for induction of cytolysis by the T cell antigenFc receptor ζ chain

1992 • 333 citations

Oncogenes, Growth Factors, and Signal Transduction

1989 • 296 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

1987 • 247 citations

Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C.

1989 • 226 citations

Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.

1992 • 181 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.

1990 • 158 citations

Human T cell activation. I. Monocyte-independent activation and proliferation induced by anti-T3 monoclonal antibodies in the presence of tumor promoter 12-o-tetradecanoyl phorbol-13 acetate.

1985 • 155 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

1987 • 141 citations

Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.

1989 • 128 citations

The isolation and sequence of a novel gene from a human functional T cell line.

1987 • 120 citations

Structure and expression of Ick transcripts in human lymphoid cells

1988 • 104 citations

Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C.

1988 • 103 citations

Biochemical identification of a direct physical interaction between the CD4: p56^lck and T_i(TcR)/CD3 complexes

1991 • 85 citations

Biochemical Characterization of the η Chain of the T-cell Receptor

1989 • 80 citations

Protein tyrosine kinase p59^fyn is associated with the T cell receptor‐CD3 complex in functional human lymphocytes

1992 • 67 citations

Function of a Heterologous Muscarinic Receptor in T Cell Antigen Receptor Signal Transduction Mutants

1989 • 58 citations

Use of an Epstein-Barr virus episomal replicon for anti-sense RNA-mediated gene inhibition in a human cytotoxic T-cell clone.

1988 • 55 citations

At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.

1988 • 42 citations

Structure of the human lck gene: differences in genomic organisation within src-related genes affect only N-terminal exons

1989 • 32 citations

Expression of v-src in a murine T-cell hybridoma results in constitutive T-cell receptor phosphorylation and interleukin 2 production.

1991 • 25 citations

Characterization of a Monoclonal Antibody Directed Against the Phosphotyrosine Kinase p56^lck, in Human T Cells

1991 • 11 citations