SH2 domains, interaction modules and cellular wiring

Translating the Histone Code

2001 • 9,488 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

STATs and Gene Regulation

1997 • 3,927 citations

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

2001 • 2,749 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

1997 • 1,592 citations

BIND--The Biomolecular Interaction Network Database

2001 • 1,591 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

1998 • 951 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

SH3 domains: complexity in moderation

2001 • 778 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

2001 • 761 citations

Protein–protein interactions define specificity in signal transduction

2000 • 757 citations

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

2001 • 679 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING

1997 • 558 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p

2000 • 508 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

The Molecular Basis of FHA Domain:Phosphopeptide Binding Specificity and Implications for Phospho-Dependent Signaling Mechanisms

2000 • 449 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins.

1993 • 423 citations

Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway

2001 • 400 citations

The FHA Domain Is a Modular Phosphopeptide Recognition Motif

1999 • 395 citations

Dynamic Coupling between the SH2 and SH3 Domains of c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation

2001 • 386 citations

Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex

2001 • 380 citations

Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation

1998 • 377 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells

2001 • 354 citations

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

2001 • 313 citations

Proteolysis and the cell cycle: with this RING I do thee destroy

2000 • 308 citations

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

2001 • 304 citations

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1999 • 299 citations

Negative regulation of the JAK/STAT pathway

1999 • 288 citations

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

2001 • 258 citations

Crystal Structures of the XLP Protein SAP Reveal a Class of SH2 Domains with Extended, Phosphotyrosine-Independent Sequence Recognition

1999 • 244 citations

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-$gamma;1 complexed with a high affinity binding peptide

1994 • 239 citations

Direct Binding of C-terminal Region of p130 to SH2 and SH3 Domains of Src Kinase

1996 • 229 citations

Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling

1998 • 226 citations

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

2001 • 211 citations

Complex Formation with Focal Adhesion Kinase: A Mechanism to Regulate Activity and Subcellular Localization of Src Kinases

1999 • 201 citations

Identification of an Atypical Grb2 Carboxyl-terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-dependent and -independent Recruitment of Gab1 to Receptor Tyrosine Kinases

2000 • 181 citations

Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues

2001 • 180 citations

Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases

2000 • 171 citations

DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding

1999 • 161 citations

Interaction between PAK and Nck: a Template for Nck Targets and Role of PAK Autophosphorylation

2000 • 149 citations

The Epstein–Barr Virus Latent Membrane Protein 2A PY Motif Recruits WW Domain-Containing Ubiquitin-Protein Ligases

2000 • 141 citations

Diversity in protein recognition by PTB domains

1999 • 131 citations

The NH ₂ -Terminal Coiled-Coil Domain and Tyrosine 177 Play Important Roles in Induction of a Myeloproliferative Disease in Mice by Bcr-Abl

2001 • 126 citations

Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

1999 • 109 citations

Signal transduction by wild-type and leukemogenic Abl proteins

1997 • 107 citations

Regulation of Epstein—Barr virus latency by latent membrane protein 2

1996 • 87 citations

Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis

2001 • 55 citations

Structural Basis for Specificity Switching of the Src SH2 Domain

2000 • 45 citations

[34] Biochemical analysis of SH2 domain-mediated protein interactions

1995 • 14 citations