Cytokine Signaling in 2002

Translating the Histone Code

2001 • 9,488 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

STATs in oncogenesis

2000 • 1,723 citations

Cytokine receptor signalling

1995 • 1,242 citations

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

2000 • 1,191 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Serine phosphorylation of STATs

2000 • 873 citations

SOCS Proteins: Negative Regulators of Cytokine Signaling

2001 • 807 citations

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 • 743 citations

The Stat family in cytokine signaling

2001 • 723 citations

NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

2000 • 690 citations

Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue

2001 • 679 citations

Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT Signaling

2001 • 636 citations

Negative Regulation of Cytokine Signaling Pathways

2000 • 607 citations

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

2001 • 555 citations

Interleukin 20

2001 • 542 citations

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

2001 • 535 citations

Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R

2000 • 531 citations

Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation

2001 • 507 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

STAT proteins and transcriptional responses to extracellular signals

2000 • 484 citations

Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription

2001 • 475 citations

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

2000 • 465 citations

IFN-γ production by antigen-presenting cells: mechanisms emerge

2001 • 456 citations

TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B

2001 • 455 citations

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

2001 • 420 citations

Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

2000 • 412 citations

WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection

2001 • 409 citations

Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor

2000 • 405 citations

Immune Response in Stat2 Knockout Mice

2000 • 399 citations

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

2000 • 394 citations

Modulation of STAT signaling by STAT-interacting proteins

2000 • 372 citations

Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain

2000 • 351 citations

Biologic consequences of Stat1-independent IFN signaling

2001 • 345 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver

2001 • 331 citations

Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless

2001 • 325 citations

The biology of Stat4 and Stat6

2000 • 310 citations

Tyk2 Plays a Restricted Role in IFNα Signaling, Although It Is Required for IL-12-Mediated T Cell Function

2000 • 310 citations

Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2

2000 • 310 citations

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

2001 • 304 citations

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

2001 • 302 citations

Paracrine Signaling through the JAK/STAT Pathway Activates Invasive Behavior of Ovarian Epithelial Cells in Drosophila

2001 • 301 citations

The N-Terminal Domain of Janus Kinase 2 Is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor

2001 • 295 citations

Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox

2000 • 293 citations

Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion

2001 • 281 citations

Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha

2002 • 266 citations

Stat1-independent regulation of gene expression in response to IFN-γ

2001 • 243 citations

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

2001 • 242 citations

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

2001 • 222 citations

The V Protein of Human Parainfluenza Virus 2 Antagonizes Type I Interferon Responses by Destabilizing Signal Transducer and Activator of Transcription 2

2001 • 215 citations

Distinct Requirements for IFNs and STAT1 in NK Cell Function

2000 • 214 citations

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

2001 • 211 citations

Role of Nucleoporin Induction in Releasing an mRNA Nuclear Export Block

2002 • 198 citations

Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor

2000 • 197 citations

Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5

2000 • 196 citations

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

2001 • 195 citations

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

2000 • 190 citations

Antiapoptotic activity ofStat5required during terminal stages of myeloid differentiation

2000 • 188 citations

SOCS-1/SSI-1-Deficient NKT Cells Participate in Severe Hepatitis through Dysregulated Cross-Talk Inhibition of IFN-γ and IL-4 Signaling In Vivo

2001 • 185 citations

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

2001 • 182 citations

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

2000 • 177 citations

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation

2001 • 175 citations

Constitutive and IFN-γ-induced nuclear import of STAT1 proceed through independent pathways

2002 • 173 citations

Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5

2000 • 171 citations

The roles of the Drosophila JAK/STAT pathway

2000 • 164 citations

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5

2002 • 153 citations

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

2001 • 152 citations

Unexpected Effects of FERM Domain Mutations on Catalytic Activity of Jak3

2001 • 139 citations

Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock

2002 • 137 citations

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2

2001 • 136 citations

Arginine/Lysine-rich Structural Element Is Involved in Interferon-induced Nuclear Import of STATs

2001 • 135 citations

Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains

2000 • 135 citations

Janus kinase 3 (Jak3) is essential for common cytokine receptor γ chain (γc)-dependent signaling: comparative analysis of γc, Jak3, and γc and Jak3 double-deficient mice

2000 • 127 citations

STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells

2002 • 124 citations

A small amphipathic alpha -helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5

2000 • 121 citations

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff

2002 • 119 citations

Stat4 Regulates Multiple Components of IFN-γ-Inducing Signaling Pathways

2000 • 114 citations

Stat3 in Thymic Epithelial Cells Is Essential for Postnatal Maintenance of Thymic Architecture and Thymocyte Survival

2001 • 109 citations

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

2000 • 109 citations

Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency

2001 • 108 citations

Identification of a Novel Immunoreceptor Tyrosine-based Activation Motif-containing Molecule, STAM2, by Mass Spectrometry and Its Involvement in Growth Factor and Cytokine Receptor Signaling Pathways

2000 • 108 citations

Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis

2001 • 106 citations

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)

2002 • 102 citations

A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling

2000 • 97 citations

An Essential Role for Daxx in the Inhibition of B Lymphopoiesis by Type I Interferons

2001 • 94 citations

Designing Small-Molecule Switches for Protein-Protein Interactions

2000 • 91 citations

STAT1 from the cell membrane to the DNA

2001 • 89 citations

Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression

2002 • 89 citations

STAT signalling in cell proliferation and in development

2000 • 87 citations

Tyrosine Phosphorylation-Independent Nuclear Translocation of a Dictyostelium STAT in Response to DIF Signaling

2001 • 85 citations

An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element

2000 • 77 citations

Unexpected and variable phenotypes in a family with JAK3 deficiency

2001 • 72 citations

STAM2, a new member of the STAM family, binding to the Janus kinases

2000 • 70 citations

Jak3 Selectively Regulates Bax and Bcl-2 Expression To Promote T-Cell Development

2001 • 64 citations

SH2-B Family Members Differentially Regulate JAK Family Tyrosine Kinases

2002 • 61 citations

A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130

2001 • 56 citations

The JAK/STAT Signaling Pathway Is Required for the Initial Choice of Sexual Identity in Drosophila melanogaster

2000 • 53 citations

STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia

2001 • 51 citations

Loss of Hippocampal CA3 Pyramidal Neurons in Mice Lacking STAM1

2001 • 50 citations

STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia

2001 • 48 citations

A Profound Deficiency in Thymic Progenitor Cells in Mice Lacking Jak3

2000 • 32 citations

Transcriptional regulation in lymphocytes

2001 • 24 citations

Cutting Edge: Two Distinct Mechanisms Lead to Impaired T Cell Homeostasis in Janus Kinase 3- and CTLA-4-Deficient Mice

2001 • 22 citations

A New IFN-Like Cytokine, Limitin Modulates the Immune Response Without Influencing Thymocyte Development

2001 • 16 citations