CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

Regulation of B Cell Antigen Receptor Signal Transduction and Phosphorylation by CD45

1991 • 269 citations

Specific Expression of a Tyrosine Kinase Gene, blk , in B Lymphoid Cells

1990 • 234 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.

1988 • 208 citations

Regulation of the p59^fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase

1992 • 179 citations

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

1991 • 175 citations

Alterations of the Lymphocyte-Specific Protein Tyrosine Kinase (p56^lck) during T-Cell Activation

1988 • 169 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.

1990 • 151 citations

Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck.

1990 • 142 citations

CD45. A prototype for transmembrane protein tyrosine phosphatases.

1991 • 142 citations

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.

1990 • 129 citations

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli.

1991 • 109 citations

A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56^lck and pp³², a possible common substrate

1991 • 104 citations

Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes.

1989 • 103 citations

Transfer of proteins to membranes facilitates both cyanogen bromide cleavage and two-dimensional proteolytic mapping.

1990 • 100 citations

Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.

1990 • 85 citations

The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation.

1990 • 73 citations

Neoplastic Transformation Induced by an Activated Lymphocyte-Specific Protein Tyrosine Kinase (pp56^lck)

1988 • 66 citations

Structural differences between repressed and derepressed forms of p60c-src.

1989 • 49 citations

Site-Directed Mutagenesis of the SH2- and SH3-Coding Domains of c-src Produces Varied Phenotypes, Including Oncogenic Activation of p60^c-src

1990 • 47 citations

Activation of p56^lck through Mutation of a Regulatory CarboxyTerminal Tyrosine Residue Requires Intact Sites of Autophosphorylation and Myristylation

1990 • 38 citations

Activation of the Proto-Oncogene p60^c-src by Point Mutations in the SH2 Domain

1990 • 35 citations

SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src.

1990 • 29 citations

Alterations in Tyrosine Protein Phosphorylation Induced by Antibody-Mediated Cross-Linking of the CD4 Receptor of T Lymphocytes

1989 • 29 citations

Avian CD4 and CD8 interact with a cellular tyrosine protein kinase homologous to mammalian p56^lck

1991 • 28 citations

Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system.

1991 • 28 citations

Structural Differences between Repressed and Derepressed Forms of p60^c-src

1989 • 18 citations

CD8⁺ T-Cell Clones Deficient In the Expression of the CD45 Protein Tyrosine Phosphatase Have Impaired Responses to T-Cell Receptor Stimuli

1991 • 18 citations

src-related protein tyrosine kinases

1989 • 12 citations

Characterization of a Monoclonal Antibody Directed Against the Phosphotyrosine Kinase p56^lck, in Human T Cells

1991 • 11 citations

Ligand-induced association between the T-cell antigen receptor and two glycoproteins.

1989 • 9 citations