SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

Protein modules and signalling networks

1995 • 2,447 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain

1996 • 433 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

1996 • 364 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

1996 • 336 citations

HIV accessory proteins: Leading roles for the supporting cast

1995 • 283 citations

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

1987 • 278 citations

A tail of two src's: Mutatis mutandis

1987 • 278 citations

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

1993 • 272 citations

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.

1995 • 256 citations

Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

1987 • 253 citations

Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

1995 • 252 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.

1994 • 235 citations

Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells

1993 • 222 citations

Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.

1994 • 198 citations

Centrifugal enhancement of retroviral mediated gene transfer

1995 • 189 citations

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.

1993 • 180 citations

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.

1992 • 179 citations

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions.

1995 • 163 citations

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.

1990 • 151 citations

Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

1994 • 148 citations

Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.

1993 • 132 citations

Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages.

1993 • 121 citations

Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages.

1992 • 115 citations

The Fc gamma RI receptor signals through the activation of hck and MAP kinase.

1995 • 114 citations

Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation.

1988 • 102 citations

Structures of SH2 and SH3 domains

1993 • 92 citations

Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes

1991 • 91 citations

Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.

1993 • 85 citations

The Ras GTPase-activating Protein (GAP) Is an SH3 Domain-binding Protein and Substrate for the Src-related Tyrosine Kinase, Hck

1995 • 79 citations

Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells.

1987 • 68 citations

HIV's Other Immune-System Targets: Macrophages

1996 • 27 citations

Pathway to understanding AIDS

1996 • 10 citations