Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene.

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester.

1991 • 419 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Signalling through SH2 and SH3 domains

1993 • 355 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

Cell-free activation of a DNA-binding protein by epidermal growth factor

1993 • 263 citations

Structure of the regulatory domains of the Src-family tyrosine kinase Lck

1994 • 247 citations

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

1992 • 242 citations

Specific Expression of a Tyrosine Kinase Gene, blk , in B Lymphoid Cells

1990 • 234 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.

1988 • 208 citations

Identification of a Transcriptional Enhancer Element Upstream from the Proto-Oncogene fos

1985 • 171 citations

Inducible binding of a factor to the c-fos regulatory region.

1987 • 168 citations

New human gene encoding a positive modulator of HIV Tat-mediated transactivation

1992 • 163 citations

Regulation of src family tyrosine kinases in lymphocytes

1993 • 144 citations

Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.

1993 • 132 citations

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.

1990 • 129 citations

Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells

1989 • 99 citations

src-related protein tyrosine kinases and their surface receptors

1993 • 84 citations

Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

1992 • 82 citations

c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.

1992 • 76 citations

Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development

1994 • 75 citations

Src-related protein tyrosine kinases and T-cell receptor signalling

1992 • 73 citations

Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes

1989 • 60 citations