Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Nucleotide sequence of rous sarcoma virus

1983 • 901 citations

SH2 and SH3 domains

1993 • 697 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Maps from two interspecific backcross DNA panels available as a community genetic mapping resource

1994 • 587 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Binding and Stimulation of HIV-1 Integrase by a Human Homolog of Yeast Transcription Factor SNF5

1994 • 523 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA

1980 • 474 citations

Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase

1981 • 439 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

Lymphosarcoma: virus-induced thymic-independent disease in mice.

1970 • 414 citations

Dominant negative MYC blocks transformation by ABL oncogenes

1992 • 410 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

c-Abl kinase regulates the protein binding activity of c-Crk.

1994 • 362 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias.

1993 • 317 citations

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

1994 • 313 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Direct transformation of 3T3 cells by Abelson murine leukaemia virus

1975 • 288 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

1992 • 258 citations

In vitro transformation of lymphoid cells by Abelson murine leukemia virus.

1975 • 247 citations

The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.

1991 • 224 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA

1992 • 202 citations

The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.

1990 • 196 citations

Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells

1994 • 187 citations

Abl tyrosine kinase in signal transduction and cell-cycle regulation

1993 • 177 citations

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

1994 • 175 citations

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

1992 • 168 citations

The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites.

1993 • 165 citations

Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation

1983 • 165 citations

The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

1990 • 157 citations

The mechanism of cytoplasmic orthopoxvirus DNA replication

1981 • 143 citations

An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement.

1994 • 134 citations

Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster.

1988 • 119 citations

G₁ Cyclin Degradation: the PEST Motif of Yeast Cln2 Is Necessary, but Not Sufficient, for Rapid Protein Turnover

1994 • 108 citations

Rearrangements involving chromosome band 11Q23 in acute leukaemia.

1993 • 108 citations

Influence of prednisolone on Moloney leukemogenic virus in BALB-c mice.

1970 • 104 citations

Abelson murine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation

1980 • 101 citations

Lethal effect of the abelson murine leukemia virus transforming gene product

1981 • 101 citations

Abelson murine leukemia virus mutants with alterations in the virus-specific P120 molecule

1980 • 90 citations

The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes.

1994 • 81 citations

Genome structure of Abelson murine leukemia virus variants: proviruses in fibroblasts and lymphoid cells

1981 • 79 citations

Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4.

1992 • 65 citations

Genetic assay for multimerization of retroviral gag polyproteins

1992 • 65 citations

Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context.

1992 • 64 citations

Site-directed deletions of Abelson murine leukemia virus define 3' sequences essential for transformation and lethality

1983 • 57 citations

Oncogenic Activation of c-ABL by Mutation within Its Last Exon

1993 • 51 citations

Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1.

1992 • 49 citations

The protein tyrosine kinase substrate cortactin is differentially expressed in murine B lymphoid tumors.

1994 • 41 citations

Deletion of a homeobox gene in myeloid leukemias with a deletion in chromosome 2

1988 • 38 citations

Mutation of a phenylalanine conserved in SH3-containing tyrosine kinases activates the transforming ability of c-Abl.

1993 • 37 citations

The Role of MYC in Transformation by BCR-ABL

1993 • 37 citations

Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert

1987 • 33 citations

SH2 and SH3 domains

1992 • 31 citations

Abl-mediated transformation, immunoglobulin gene rearrangements and arrest of B lymphocyte differentiation.

1994 • 30 citations

The cloning and characterization of a localized maternal transcript in Xenopus laevis whose zygotic counterpart is detected in the CNS

1992 • 25 citations

Cloning and functional expression of the mouse homologue of p47 phox

1994 • 24 citations

Abelson murine leukemia virus variants with increased oncogenic potential

1986 • 21 citations

Carboxyl-terminal determinants of Abelson protein important for lymphoma induction

1991 • 11 citations

Transforming activity and tissue tropism of hybrid retroviral genomes containing portions of the v-abl and v-src oncogenes.

1993 • 7 citations

Arrested development: Understanding v‐abl

1994 • 6 citations

Bone marrow-transforming activity of linker insertion mutants of Abelson murine leukemia virus.

1992 • 6 citations