The EGFR family and its ligands in human cancer

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1995 • 1,035 citations

A Hierarchical Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor

1996 • 1,021 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

EGF receptor

1999 • 792 citations

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.

1996 • 675 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors

1999 • 548 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

1998 • 400 citations

The gene lin-3 encodes an inductive signal for vulval development in C. elegans

1992 • 392 citations

Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.

2000 • 345 citations

Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development

1999 • 260 citations

A thousand and one roles for the Drosophila EGF receptor

1997 • 250 citations

Molecular Aspects of Mesenchymal-Epithelial Interactions

1993 • 232 citations

Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network

1998 • 116 citations

C. elegans vulval development as a model system to study the cancer biology of EGFR signaling.

1999 • 36 citations

The EGFR as a target for viral oncoproteins

1999 • 30 citations

Transmembrane signalling receptors for cytokines and growth factors

1991 • 14 citations