Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1989 • 2,603 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells

1998 • 733 citations

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1995 • 597 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Prediction of the Coding Sequences of Unidentified Human Genes. II. The Coding Sequences of 40 New Genes (KIAA0041-KIAA0080) Deduced by Analysis of cDNA Clones from Human Cell Line KG-1

1994 • 500 citations

Binding of acylated peptides and fatty acids to phospholipid vesicles: Pertinence to myristoylated proteins

1993 • 498 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

1996 • 465 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule

1996 • 439 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

1997 • 405 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Cloning and sequence of multiple forms of phospholipase C

1988 • 342 citations

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

1996 • 328 citations

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

1998 • 328 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

PH domain: the first anniversary

1994 • 318 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

The pleckstrin homology domain of phospholipase C-.delta.1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes

1995 • 286 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

Structure of the binding site for inositol phosphates in a PH domain.

1995 • 281 citations

Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin

1994 • 268 citations

Molecular cloning and expression of the major protein kinase C substrate of platelets

1988 • 250 citations

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

1998 • 249 citations

Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia

1997 • 240 citations

Structure of the pleckstrin homology domain from β-spectrin

1994 • 233 citations

Solution structure of a pleckstrin-homology domain

1994 • 211 citations

Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding Capacity

1996 • 203 citations

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

1993 • 173 citations

Molecular Cloning of a Novel Diacylglycerol Kinase Isozyme with a Pleckstrin Homology Domain and a C-terminal Tail Similar to Those of the EPH Family of Protein-tyrosine Kinases

1996 • 163 citations

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

1997 • 155 citations

Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 151 citations

Phosphoinositide 3-OH Kinase Activates the β2Integrin Adhesion Pathway and Induces Membrane Recruitment of Cytohesin-1

1998 • 148 citations

Targeting of Tiam1 to the Plasma Membrane Requires the Cooperative Function of the N-terminal Pleckstrin Homology Domain and an Adjacent Protein Interaction Domain

1997 • 145 citations

Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1.

1994 • 141 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

Phosphatidylinositol 3-Kinase Mediates Epidermal Growth Factor-Induced Activation of the c-Jun N-Terminal Kinase Signaling Pathway

1997 • 133 citations

High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.

1992 • 123 citations

Phospholipase C δ1 requires a pleckstrin homology domain for interaction with the plasma membrane

1995 • 122 citations

Crystal structure of the pleckstrin homology domain from dynamin

1994 • 120 citations

Pleckstrin Homology Domains

1998 • 112 citations

The Pleckstrin Homology Domain of RAC Protein Kinase Associates with the Regulatory Domain of Protein Kinase C ζ

1994 • 98 citations

Three-dimensional solution structure of the pleckstrin homology domain from dynamin

1994 • 92 citations

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

1997 • 91 citations

Characterization of the Pleckstrin Homology Domain of Btk as an Inositol Polyphosphate and Phosphoinositide Binding Domain

1997 • 89 citations

Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1 IP4BP and GAP1 m result from the GAP1 IP4BP PH domain directing plasma membrane targeting

1997 • 88 citations

Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy.

1995 • 88 citations

Characterization of human brain cDNA encoding the general isoform of beta-spectrin.

1992 • 87 citations

Structure-Function Relationships of the Mouse Gap1m

1996 • 80 citations

The Solution Structure and Dynamics of the Pleckstrin Homology Domain of G Protein-coupled Receptor Kinase 2 (β-Adrenergic Receptor Kinase 1)

1998 • 75 citations

Pleckstrin Associates with Plasma Membranes and Induces the Formation of Membrane Projections: Requirements for Phosphorylation and the NH2-terminal PH Domain

1997 • 73 citations

Scratching the surface with the PH domain

1995 • 62 citations

The Solution Structure of the Pleckstrin Homology Domain of Human SOS1

1997 • 61 citations

The Pleckstrin Homology Domain of Human βIΣII Spectrin Is Targeted to the Plasma Membranein Vivo

1996 • 59 citations

The solution structure of the pleckstrin homology domain of mouse son-of-sevenless 1 (msos1)

1997 • 50 citations

Specificity of the purified inositol (1,3,4,5) tetrakisphosphate‐binding protein from porcine platelets

1995 • 32 citations

Method for Efficient Pelleting of Small Unilamellar Model Membrane Vesicles

1994 • 17 citations