Autophosphorylation Induces Autoactivation and a Decrease in the Src Homology 2 Domain Accessibility of the Lyn Protein Kinase

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

The when and how of Src regulation

1993 • 543 citations

CSK: a protein-tyrosine kinase involved in regulation of src family kinases.

1991 • 522 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

α‐Cyano‐4‐hydroxycinnamic acid as a matrix for matrixassisted laser desorption mass spectromtry

1992 • 420 citations

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

1993 • 307 citations

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.

1994 • 219 citations

The B-cell antigen receptor complex: structure and signal transduction

1994 • 204 citations

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

1988 • 176 citations

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

1991 • 175 citations

Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.

1993 • 159 citations

A synthetic peptide derived from p34cdc2 is a specific and efficient substrate of src-family tyrosine kinases.

1992 • 151 citations

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.

1993 • 117 citations

Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages.

1992 • 115 citations

Regulation by the Autophosphorylation Site in Overexpressed pp60^c-src

1988 • 108 citations

Synthesis of phosphotyrosine-containing peptides and their use as substrates for protein tyrosine phosphatases

1993 • 101 citations

Purification and enzymatic characterization of pp60c-src from human platelets.

1990 • 85 citations

Alternatively spliced murine lyn mRNAs encode distinct proteins.

1991 • 81 citations

A conserved helix motif complements the protein kinase core.

1993 • 71 citations

The B‐Cell Antigen Receptor: Structure and Function of Primary, Secondary, Tertiary and Quaternary Components

1993 • 56 citations

Association of Src‐Family Kinase Lyn with B‐Cell Antigen Receptor

1993 • 54 citations

Identification and characterization of the hamster polyomavirus middle T antigen

1991 • 52 citations

Evidence for autoinhibitory regulation of the c-src gene product. A possible interaction between the src homology 2 domain and autophosphorylation site.

1993 • 46 citations

Structural basis of specific and efficient phosphorylation of peptides derived from p34cdc2 by a pp60src-related protein tyrosine kinase.

1991 • 46 citations

Purification and characterization of a pp60c-src-related tyrosine kinase that effectively phosphorylates a synthetic peptide derived from p34cdc2

1991 • 43 citations

Characterization of purified pp60^c‐src protein tyrosine kinase from human platelets

1990 • 30 citations

Phosphopeptide occupancy and photoaffinity cross-linking of the v-Src SH2 domain attenuates tyrosine kinase activity.

1994 • 14 citations