The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

SH2 and SH3 domains

1993 • 697 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

A polypeptide domain that specifies migration of nucleoplasmin into the nucleus

1982 • 556 citations

Differential expression of cellular oncogenes during pre- and postnatal development of the mouse

1982 • 540 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

Dominant negative MYC blocks transformation by ABL oncogenes

1992 • 410 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Nuclear location signals in polyoma virus large-T

1986 • 351 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias.

1993 • 317 citations

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

1994 • 313 citations

The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen.

1988 • 296 citations

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

1992 • 295 citations

Alternative 5′ exons in c-abl mRNA

1986 • 290 citations

The novel activation of ABL by fusion to an ets-related gene, TEL.

1995 • 289 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.

1995 • 268 citations

Evidence of a New Chimericbcr/c-ablmRNA in Patients with Chronic Myelocytic Leukemia and the Philadelphia Chromosome

1985 • 253 citations

Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.

1983 • 253 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA

1992 • 202 citations

Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation.

1993 • 190 citations

Pentapeptide nuclear localization signal in adenovirus E1a.

1987 • 165 citations

Differential Phosphorylation of c-Abl in Cell Cycle Determined by cdc 2 Kinase and Phosphatase Activity

1990 • 157 citations

The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

1990 • 157 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.

1990 • 135 citations

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

1995 • 133 citations

Characterization of nuclear localizing sequences derived from yeast ribosomal protein L29.

1990 • 104 citations

Abelson murine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation

1980 • 101 citations

Lethal effect of the abelson murine leukemia virus transforming gene product

1981 • 101 citations

A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.

1993 • 98 citations

BCR First Exon Sequences Specifically Activate the BCR/ABL Tyrosine Kinase Oncogene of Philadelphia ChromosomePositive Human Leukemias

1991 • 97 citations

Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes.

1991 • 94 citations

Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal.

1990 • 87 citations

Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation.

1987 • 81 citations

Transfection of Fibroblasts by Cloned Abelson Murine Leukemia Virus DNA and Recovery of Transmissible Virus by Recombination with Helper Virus

1982 • 78 citations

Point Mutations in theablSH2 Domain Coordinately Impair Phosphotyrosine Binding In Vitro and Transforming Activity In Vivo

1992 • 70 citations

Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context.

1992 • 64 citations

Biological response to phorbol ester determined by alternative G1 pathways.

1995 • 59 citations

c-abl has a sequence-specific enhancer binding activity

1992 • 58 citations

Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine.

1987 • 57 citations

Site-directed deletions of Abelson murine leukemia virus define 3' sequences essential for transformation and lethality

1983 • 57 citations

Two nuclear localization signals present in the basic-helix 1 domains of MyoD promote its active nuclear translocation and can function independently.

1995 • 56 citations

Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal

1993 • 53 citations

Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro.

1995 • 52 citations

Oncogenic Activation of c-ABL by Mutation within Its Last Exon

1993 • 51 citations

Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.

1992 • 51 citations

Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variants.

1993 • 51 citations

Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines.

1988 • 47 citations

HPV-16 E7 or adenovirus E1A can overcome the growth arrest of cells immortalized with a temperature-sensitive p53.

1993 • 38 citations

Oncogenic activation of c-ABL by mutation within its last exon.

1993 • 38 citations

Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis.

1987 • 38 citations

Mutation of a phenylalanine conserved in SH3-containing tyrosine kinases activates the transforming ability of c-Abl.

1993 • 37 citations

Normal Cellular and Transformation-Associated abl Proteins Share Common Sites fOr Protein Kinase C Phosphorylation

1987 • 35 citations

Cell cycle arrest by tyrosine kinase Abl involves altered early mitogenic response.

1995 • 32 citations

A temperature sensitive mutant of the human p53, Val138, arrests rat cell growth without induced expression of cip1/waf1/sdi1 after temperature shift-down.

1995 • 28 citations

Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.

1987 • 27 citations

A Bipartite Nuclear Localization Signal in the Retinoblastoma Gene Product and Its Importance for Biological Activity

1993 • 26 citations

Nonmyristoylated Abl Proteins Transform a Factor-Dependent Hematopoietic Cell Line

1992 • 19 citations

Nuclear Localization of v-Abl Leads to Complex Formation with Cyclic AMP Response Element (CRE)-Binding Protein and Transactivation through CRE Motifs

1995 • 19 citations

Deregulation of c-abl mediated cell growth after retroviral transfer and expression of antisense sequences.

1995 • 18 citations

Differential Expression of Type-Specific c-abl mRNAs in Mouse Tissues and Cell Lines

1988 • 10 citations