Constitutive activation of Src family kinases in mouse embryos that lack Csk

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Oncogenes and signal transduction

1991 • 2,816 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

The mouse; its reproduction and development

1968 • 1,290 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

CSK: a protein-tyrosine kinase involved in regulation of src family kinases.

1991 • 522 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

1990 • 480 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro.

1984 • 405 citations

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.

1989 • 349 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

A Protein Tyrosine Kinase Involved in Regulation of pp60c-src function

1989 • 309 citations

p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo.

1992 • 266 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection.

1990 • 241 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.

1992 • 181 citations

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

1987 • 179 citations

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

1988 • 176 citations

pp60c-src in the developing cerebellum.

1985 • 147 citations

Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies.

1988 • 121 citations

Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

1987 • 117 citations

src-related tyrosine protein kinases as signaling components in hematopoietic cells.

1990 • 109 citations

Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein.

1992 • 100 citations

Polymorphisms in the coding and noncoding regions of murinePgk-1 alleles

1990 • 95 citations

Phosphorylation of c-Src on Tyrosine 527 by Another Protein Tyrosine Kinase

1991 • 92 citations

Efficacious Production of Viable Germ-Line Chimeras between Embryonic Stem (ES) Cells and 8-Cell Stage Embryos. (embryonic stem cell/mouse embryo chimera/germ line transmission)

1992 • 70 citations

RNA polymerase II is capable of pausing and prematurely terminating transcription at a precise location in vivo and in vitro.

1989 • 69 citations

Atlas of embryonic development

1984 • 64 citations

Association of Src-Like Protein Tyrosine Kinases with the CD2 Cell Surface Molecule in Rat T Lymphocytes and Natural Killer Cells

1992 • 62 citations

Cyclic AMP response element-binding protein, CRE-BP1, mediates the E1A-induced but not the Tax-induced trans-activation.

1991 • 60 citations

Nonmyristoylated p60v-src fails to phosphorylate proteins of 115-120 kDa in chicken embryo fibroblasts.

1988 • 55 citations

An early developmental phase of pp60c-src expression in the neural ectoderm

1986 • 54 citations

Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527.

1988 • 54 citations

Association between B-Lymphocyte Membrane Immunoglobulin and Multiple Members of the Src Family of Protein Tyrosine Kinases

1992 • 52 citations

Myelin Basic Protein Gene and the Function of Antisense RNA in Its Repression in Myelin‐Deficient Mutant Mouse

1991 • 46 citations

Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK.

1993 • 33 citations

Expression of c-kit, a proto-oncogene of the murine W locus, in cerebella of normal and neurological mutant mice: Immunohistochemical and in situ hybridization analysis

1992 • 19 citations

Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis.

1989 • 17 citations