Modulation of the SH2 Binding Specificity and Kinase Activity of Src by Tyrosine Phosphorylation within Its SH2 Domain

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Techniques in Protein Chemistry

1993 • 1,285 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Involvement of pp60c-src with two major signaling pathways in human breast cancer.

1994 • 273 citations

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class.

1995 • 270 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1994 • 253 citations

Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.

1988 • 250 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

Src Phosphorylation of the Epidermal Growth Factor Receptor at Novel Sites Mediates Receptor Interaction with Src and P85α

1995 • 213 citations

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

1994 • 212 citations

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

1985 • 207 citations

Augmented Mitogenic Responsiveness to Epidermal Growth Factor in Murine Fibroblasts That Overexpress pp60^c-src

1988 • 147 citations

Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains

1992 • 107 citations

Activation of p56^lck by p72^syk through Physical Association and N-Terminal Tyrosine Phosphorylation†

1994 • 94 citations

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.

1994 • 92 citations

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

1988 • 87 citations

Translocation of pp60c-src from the plasma membrane to the cytosol after stimulation by platelet-derived growth factor.

1993 • 73 citations

Regulation of the Src protein tyrosine kinase

1995 • 69 citations

The cell cycle and c-Src

1993 • 66 citations

Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation.

1994 • 59 citations

Anti-CD3 and phorbol ester induce distinct phosphorylated sites in the SH2 domain of p56lck.

1993 • 54 citations

Cdc2-mediated modulation of pp60c-src activity.

1994 • 51 citations

Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors.

1993 • 50 citations

Purification and biochemical characterization of non-myristoylated recombinant pp60c-src kinase

1992 • 29 citations