The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

1994 • 538 citations

Neurotrophin signal transduction by the Trk receptor

1994 • 511 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1994 • 291 citations

Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.

1993 • 291 citations

Alteration of cellular adhesion by nerve growth factor.

1977 • 193 citations

Sequence Requirements for Binding of Src Family Tyrosine Kinases to Activated Growth Factor Receptors

1995 • 186 citations

Tyrosine 785 is a major determinant of Trk--substrate interaction.

1993 • 184 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Dissecting the Mode of Action of a Neuronal Growth Factor

1991 • 179 citations

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain

1995 • 138 citations

A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.

1994 • 132 citations

Microinjection of activated phosphatidylinositol-3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway

1998 • 128 citations

Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.

1994 • 115 citations

Direct Association of Csk Homologous Kinase (CHK) with the Diphosphorylated Site Tyr568/570 of the Activated c-KIT in Megakaryocytes

1997 • 94 citations

Identification and characterization of a novel tyrosine kinase from megakaryocytes.

1994 • 84 citations

Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes.

1994 • 70 citations

Association of Csk-homologous Kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in Breast Cancer Cells

1997 • 67 citations

Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase).

1994 • 61 citations

Structural and Functional Studies of the Intracellular Tyrosine Kinase MATK Gene and Its Translated Product

1995 • 61 citations

Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes.

1994 • 51 citations

Identification and characterization of batk, a predominantly brain‐specific non‐receptor protein tyrosine kinase related to Csk

1994 • 46 citations

Signal transduction pathways in neuronal differentiation

1993 • 46 citations

The MATK Tyrosine Kinase Interacts in a Specific and SH2-dependent Manner with c-Kit

1995 • 44 citations

Csk Homologous Kinase, a Novel Signaling Molecule, Directly Associates with the Activated ErbB-2 Receptor in Breast Cancer Cells and Inhibits Their Proliferation

1998 • 40 citations

Csk and BatK Show Opposite Temporal Expression in the Rat CNS: Consistent with its Late Expression in Development, BatK Induces Differentiation of PC12 Cells

1997 • 19 citations

Structure and developmental regulation of the murine ctk gene

1995 • 8 citations