c-Abl: activation and nuclear targets

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins

1999 • 553 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor

1998 • 514 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

Interaction between ATM protein and c-Abl in response to DNA damage

1997 • 481 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

The potential tumor suppressor p73 differentially regulates cellular p53 target genes.

1998 • 324 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias.

1993 • 317 citations

Differential Regulation of Retinoblastoma Protein Function by Specific Cdk Phosphorylation Sites

1996 • 306 citations

Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer

1997 • 300 citations

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

1998 • 286 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

1999 • 272 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

1995 • 251 citations

DNA damage and cell cycle regulation of ribonucleotide reductase

1993 • 241 citations

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

1996 • 220 citations

Regulation of Rad51 Function by c-Abl in Response to DNA Damage

1998 • 217 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA

1992 • 202 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl

1994 • 189 citations

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

1994 • 175 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Sh2 And Sh3 Domains In Signal Transduction

1994 • 138 citations

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

1995 • 133 citations

RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

1994 • 133 citations

Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin.

1997 • 129 citations

Src homology 2 domain as a specificity determinant in the c-Abl-mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain.

1995 • 114 citations

Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells

1999 • 108 citations

c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53

1999 • 104 citations

Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.

1995 • 92 citations

The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

1996 • 86 citations

Abrogation of Retinoblastoma Protein Function by c-Abl through Tyrosine Kinase-Dependent and -Independent Mechanisms

1995 • 80 citations

Functional Organization of the Hepatitis Β Virus Enhancer

1990 • 70 citations

Genotoxic Drugs Induce Interaction of the c-Abl Tyrosine Kinase and the Tumor Suppressor Protein p53

1996 • 69 citations

Nuclear c-Abl is a COOH-terminal repeated domain (CTD)-tyrosine (CTD)-tyrosine kinase-specific for the mammalian RNA polymerase II: possible role in transcription elongation.

1999 • 69 citations

c-abl has a sequence-specific enhancer binding activity

1992 • 58 citations

A Single HMG Domain in High-Mobility Group 1 Protein Binds to DNAs as Small as 20 Base Pairs Containing the Major Cisplatin Adduct

1995 • 57 citations

The transcriptional activation and repression domains of RFX1, a context-dependent regulator, can mutually neutralize their activities

1997 • 55 citations

Binding of A/T-rich DNA by Three High Mobility Group-like Domains in c-Abl Tyrosine Kinase

1996 • 51 citations

Nucleotide excision repair in the yeast Saccharomyces cerevisiae : its relationship to specialized mitotic recombination and RNA polymerase II basal transcription

1995 • 43 citations

Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-β-D-arabinofuranosylcytosine

1997 • 42 citations

Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells

1999 • 35 citations

The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes

1998 • 29 citations

Increased sensitivity to apoptotic stimuli in c-abl-deficient progenitor B-cell lines

1996 • 28 citations

The DNA Binding Domain of the Human c-Abl Tyrosine Kinase Preferentially Binds to DNA Sequences Containing an AAC Motif and to Distorted DNA Structures

1998 • 25 citations

Differential regulation of jun family gene expression by the tumor promoter okadaic acid.

1991 • 24 citations

p140/c-Abl that binds DNA is preferentially phosphorylated at tyrosine residues.

1996 • 20 citations

Deregulation of c-abl mediated cell growth after retroviral transfer and expression of antisense sequences.

1995 • 18 citations