Epidermal Growth Factor Stimulation of the ACK1/Dbl Pathway in a Cdc42 and Grb2-Dependent Manner

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Human Ect2 Is an Exchange Factor for Rho Gtpases, Phosphorylated in G2/M Phases, and Involved in Cytokinesis

1999 • 418 citations

Signaling to Rho GTPases

1999 • 411 citations

Analysis of receptor signaling pathways by mass spectrometry: Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors

2000 • 409 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

PAK to the future

1999 • 391 citations

Asef, a Link Between the Tumor Suppressor APC and G-Protein Signaling

2000 • 350 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Lck Regulates Vav Activation of Members of the Rho Family of GTPases

1997 • 305 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

p21-Activated protein kinase: a crucial component of morphological signaling?

1999 • 261 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

Isolation of a new human oncogene from a diffuse B-cell lymphoma

1985 • 210 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

2000 • 191 citations

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

1999 • 190 citations

Specific Contributions of the Small GTPases Rho, Rac, and Cdc42 to Dbl Transformation

1999 • 177 citations

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

1998 • 171 citations

Ca2+/Calmodulin-dependent Protein Kinase II Regulates Tiam1 by Reversible Protein Phosphorylation

1999 • 169 citations

The Pleckstrin Homology Domain Mediates Transformation by Oncogenic Dbl through Specific Intracellular Targeting

1996 • 136 citations

Kalirin, a Cytosolic Protein with Spectrin-like and GDP/GTP Exchange Factor-like Domains That Interacts with Peptidylglycine α-Amidating Monooxygenase, an Integral Membrane Peptide-processing Enzyme

1997 • 121 citations

αPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

1999 • 105 citations

Cloning and Characterization of a Novel Cdc42-associated Tyrosine Kinase, ACK-2, from Bovine Brain

1997 • 104 citations

Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

1988 • 93 citations

Translocation of the Rac1 Guanine Nucleotide Exchange Factor Tiam1 Induced by Platelet-derived Growth Factor and Lysophosphatidic Acid

2000 • 90 citations

Anti-apoptotic function of Rac in hematopoietic cells

1999 • 88 citations

G protein βγ subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25 ^Mm

1999 • 83 citations

Activation of the Cdc42-associated Tyrosine Kinase-2 (ACK-2) by Cell Adhesion via Integrin β1

1999 • 80 citations

Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor.

1995 • 77 citations

Induction of Rac-Guanine Nucleotide Exchange Activity of Ras-GRF1/CDC25Mm following Phosphorylation by the Nonreceptor Tyrosine Kinase Src

2000 • 68 citations

Activation of the Guanine Nucleotide Exchange Factor Dbl Following ACK1-Dependent Tyrosine Phosphorylation

2000 • 61 citations

Tyrosine phosphorylation of ACK in response to temperature shift‐down, hyperosmotic shock, and epidermal growth factor stimulation

1996 • 59 citations

Association of the proto‐oncogene product Dbl with G protein βγ subunits

1999 • 39 citations