Differential Intrinsic Enzymatic Activity of Syk and Zap-70 Protein-tyrosine Kinases

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

Current protocols in immunology

1993 • 551 citations

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

1994 • 516 citations

ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

1994 • 495 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.

1994 • 299 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

Syk Protein-tyrosine Kinase Is Regulated by Tyrosine-phosphorylated Iga/Ig/3 Immunoreceptor Tyrosine Activation Motif Binding and Autophosphorylation

1995 • 270 citations

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

1994 • 248 citations

Phospholipase C-γ1 Interacts with Conserved Phosphotyrosyl Residues in the Linker Region of Syk and Is a Substrate for Syk

1996 • 230 citations

Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE

1995 • 207 citations

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1995 • 183 citations

Tyrosine phosphorylation of band 3 inhibits peripheral protein binding.

1987 • 181 citations

p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase

1996 • 170 citations

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.

1994 • 158 citations

Binding of ZAP-70 to Phosphorylated T-Cell Receptor ζ and η Enhances Its Autophosphorylation and Generates Specific Binding Sites for SH2 Domain-Containing Proteins

1995 • 154 citations

Clustered syk tyrosine kinase domains trigger phagocytosis.

1996 • 140 citations

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.

1996 • 130 citations

Conformational Changes Induced in the Protein Tyrosine Kinase p72^syk by Tyrosine Phosphorylation or by Binding of Phosphorylated Immunoreceptor Tyrosine-Based Activation Motif Peptides

1996 • 121 citations

Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C.

1988 • 103 citations

Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase

1995 • 101 citations

Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.

1996 • 100 citations

Activation of p56^lck by p72^syk through Physical Association and N-Terminal Tyrosine Phosphorylation†

1994 • 94 citations

The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes

1995 • 83 citations

Clustering of Syk Is Sufficient To Induce Tyrosine Phosphorylation and Release of Allergic Mediators from Rat Basophilic Leukemia Cells

1995 • 71 citations

Reconstitution of B Cell Antigen Receptor-induced Signaling Events in a Nonlymphoid Cell Line by Expressing the Syk Protein-tyrosine Kinase

1996 • 57 citations

Activation of the High-Affinity Immunoglobulin E Receptor FcεRI in RBL-2H3 Cells Is Inhibited by Syk SH2 Domains

1995 • 52 citations

Interactions ofp59^fynand ZAP-70 with T-Cell Receptor Activation Motifs: Defining the Nature of a Signalling Motif

1994 • 49 citations

Molecular Characterization of the Murine SYK Protein Tyrosine Kinase cDNA, Transcripts and Protein

1995 • 47 citations

Insulin‐specific T cell hybridomas derived from (H‐2^b × H‐2^k)F₁ mice preferably employ F₁unique restriction elements for antigen recognition

1985 • 44 citations

Molecular Cloning of Rodent p72Syk.

1995 • 40 citations

Regulation of Zap-70 by Src Family Tyrosine Protein Kinases in an Antigen-specific T-cell Line

1995 • 39 citations

Cloning of the cDNA for the Deleted Syk Kinase Homologous to ZAP-70 from Human Basophilic Leukemia Cell Line (KU812)

1994 • 34 citations

tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene.

1992 • 27 citations