Multidrug Resistance in the Laboratory and Clinic

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Combination Chemotherapy in the Treatment of Advanced Hodgkin's Disease

1970 • 1,450 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Quantitation of Differential Sensitivity of Human-Tumor Stem Cells to Anticancer Drugs

1978 • 982 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1984 • 521 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex.

1993 • 508 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis [see comments]

1992 • 507 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.

1989 • 443 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Use of the polymerase chain reaction in the quantitation of MDR-1 gene expression

1990 • 427 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1986 • 410 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

1991 • 407 citations

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.

1990 • 396 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil.

1991 • 388 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1987 • 384 citations

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1983 • 384 citations

MDR1 Gene Expression and Treatment Outcome in Acute Myeloid Leukemia

1991 • 372 citations

Alternating Non-Cross-Resistant Combination Chemotherapy or MOPP in Stage IV Hodgkin's Disease

1986 • 370 citations

Induction of Multidrug Resistance in Human Cells by Transient Exposure to Different Chemotherapeutic Drugs

1993 • 366 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Functional involvement of P-glycoprotein in blood-brain barrier.

1992 • 352 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 347 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.

1992 • 322 citations

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

1986 • 321 citations

Modulation of multidrug-resistant multiple myeloma by cyclosporin

1992 • 317 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

Important Advances in Oncology 1989

1990 • 304 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

1992 • 298 citations

The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein.

1993 • 297 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 290 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1992 • 288 citations

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.

1993 • 284 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

DNA sequence of the white locus of Drosophila melanogaster

1984 • 282 citations

Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

1991 • 281 citations

Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance

1988 • 278 citations

Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

1986 • 275 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

Binding protein-dependent transport systems

1990 • 272 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells.

1978 • 268 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

P-glycoprotein in human sarcoma: evidence for multidrug resistance.

1987 • 261 citations

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis.

1991 • 261 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Reversal of multidrug resistance by surfactants

1992 • 230 citations

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

1987 • 229 citations

Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer

1991 • 228 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

DETECTION OF A MULTIDRUG RESISTANT PHENOTYPE IN ACUTE NON-LYMPHOBLASTIC LEUKAEMIA

1987 • 223 citations

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

1988 • 223 citations

Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents

1989 • 222 citations

Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance.

1992 • 221 citations

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

1989 • 217 citations

Expression of the multidrug resistance-associated P-glycoprotein (P- 170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications [see comments]

1993 • 213 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Clinical Relevance of Immunohistochemical Detection of Multidrug Resistance P-Glycoprotein in Breast Carcinoma

1991 • 208 citations

P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy

1993 • 207 citations

Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line

1987 • 205 citations

Prediction of Doxorubicin Resistance In Vitro in Myeloma, Lymphoma, and Breast Cancer by P-Glycoprotein Staining

1989 • 202 citations

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

1982 • 201 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Multidrug-resistance phenotype in Chinese hamster ovary cells.

1983 • 194 citations

Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia

1989 • 191 citations

The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

1992 • 190 citations

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.

1991 • 187 citations

Systemic Toxic Effects Associated With High-Dose Verapamil Infusion and Chemotherapy Administration

1991 • 185 citations

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues.

1984 • 182 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.

1987 • 180 citations

P-Glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance

1989 • 179 citations

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1987 • 179 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Coinduction of MDR-1 Multidrug-Resistance and Cytochrome P-450 Genes in Rat Liver by Xenobiotics

1988 • 174 citations

P-glycoproteins in pathology: The multidrug resistance gene family in humans

1990 • 173 citations

Detection of activity of P‐glycoprotein in human tumour samples using rhodamine 123

1992 • 172 citations

Expression of the multidrug resistance-associated P-glycoprotein (P- 170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications [see comments]

1993 • 171 citations

Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response.

1968 • 171 citations

Reversal of the multidrug resistance phenotype with cremophor EL, a common vehicle for water-insoluble vitamins and drugs.

1990 • 168 citations

Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line

1991 • 165 citations

P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD

1989 • 162 citations

Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene

1986 • 161 citations

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.

1990 • 157 citations

Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin.

1972 • 157 citations

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

1992 • 157 citations

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

1987 • 156 citations

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

1991 • 156 citations

Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.

1990 • 155 citations

Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines.

1988 • 154 citations

Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines.

1993 • 153 citations

Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.

1991 • 152 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

1987 • 147 citations

The effect of verapamil on the pharmacokinetics of adriamycin

1986 • 146 citations

P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines.

1989 • 144 citations

Mechanisms of multidrug resistance in HL60 cells

1989 • 140 citations

Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression.

1989 • 140 citations

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.

1992 • 140 citations

Cortisol is transported by the multidrug resistance gene product P-glycoprotein

1993 • 138 citations

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia

1989 • 135 citations

Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation.

1993 • 135 citations

Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gets

1983 • 135 citations

Expression of the multidrug resistance, MDR1, gene in neuroblastomas.

1990 • 132 citations

Phosphorylation of the multidrug resistance associated glycoprotein

1987 • 131 citations

Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype

1992 • 131 citations

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.

1990 • 129 citations

Immunohistochemical analysis of P-glycoprotein expression correlated with chemotherapy resistance in locally advanced breast cancer

1990 • 127 citations

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

1990 • 126 citations

Expression of the multidrug resistance gene product (P‐glycoprotein) in myelodysplasia is associated with a stem cell phenotype

1991 • 126 citations

Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.

1991 • 126 citations

Genetic basis of multidrug resistance of tumor cells

1990 • 124 citations

Measurement of Multidrug-Resistance Messenger RNA in Urogenital Cancers; Elevated Expression in Renal Cell Carcinoma is Associated with Intrinsic Drug Resistance

1988 • 124 citations

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

1990 • 123 citations

Efficacy of intensive chemotherapy for acute myelogenous leukemia associated with a preleukemic syndrome.

1989 • 120 citations

MEDICAL ONCOLOGY

1977 • 116 citations

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.

1992 • 114 citations

Multidrug Resistance: Molecular Biology Clinical Relevance

1989 • 114 citations

MDR1 RNA Levels in Human Renal Cell Carcinomas: Correlation With Grade and Prediction of Reversal of Doxorubicin Resistance by Quinidine in Tumor Explants

1989 • 114 citations

Cellular resistance to daunomycin in Chinese hamster cells in vitro.

1971 • 113 citations

SDZ PSC 833, A non‐immunosuppressive cyclosporine: Its potency in overcoming P‐glycoprotein‐mediated multidrug resistance of murine leukemia

1992 • 112 citations

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

1992 • 111 citations

Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.

1987 • 110 citations

Feasibility of using quinine, a potential multidrug resistance-reversing agent, in combination with mitoxantrone and cytarabine for the treatment of acute leukemia.

1992 • 108 citations

Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.

1990 • 108 citations

A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase

1993 • 107 citations

Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection.

1988 • 107 citations

Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage.

1988 • 105 citations

Immunohistochemical detection of the multidrug transport protein P1 70 in human normal tissues and malignant lymphomas

1991 • 104 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.

1986 • 102 citations

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.

1985 • 100 citations

On the characteristics of actinomycin D resistance in L5178Y cells.

1970 • 100 citations

Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression

1992 • 100 citations

Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.

1992 • 99 citations

Effect of verapamil and other agents on the distribution of anthracyclines and on reversal of drug resistance.

1987 • 96 citations

Identification of 5‘ and 3‘ sequences involved in the regulation of transcription of the human mdr1 gene in vivo.

1993 • 96 citations

Monoclonal antibody to an external epitope of the human mdr1 P-glycoprotein.

1993 • 93 citations

Expression of the multidrug transporter, P‐glycoprotein, in chronic myelogenous leukaemia cells in blast crisis

1990 • 92 citations

Phase I pharmacokinetic study of cyclosporin A combined with doxorubicin.

1993 • 91 citations

Optimization of immunocytochemical P-glycoprotein assessment in multidrug-resistant plasma cell myeloma using three antibodies.

1990 • 90 citations

Modulation of drug permeability in chinese hamster ovary cells. Possible role for phosphorylation of surface glycoproteins

1977 • 89 citations

Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage

1989 • 88 citations

Decreased retention of actinomycin D as the basis for cross-resistance in anthracycline-resistant sublines of P388 leukemia.

1977 • 87 citations

Immunohistochemical identification of P-glycoprotein in previously untreated, diffuse large cell and immunoblastic lymphomas.

1992 • 87 citations

Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

1989 • 86 citations

Restoration of doxorubicin responsiveness in doxorubicin-resistant P388 murine leukaemia cells

1984 • 86 citations

Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins

1988 • 86 citations

Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression or gene amplification.

1989 • 86 citations

Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells

1986 • 85 citations

Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles

1991 • 85 citations

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

1991 • 85 citations

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

1992 • 85 citations

Decreased nuclear matrix DNA topoisomerase II in human leukemia cells resistant to VM-26 and m-AMSA

1990 • 84 citations

The Anatomic Basis of the Blood-Brain Barrier

1989 • 83 citations

Phase I study of vinblastine and verapamil given by concurrent iv infusion.

1985 • 81 citations

Progesterone photoaffinity labels P-glycoprotein in multidrug-resistant human leukemic lymphoblasts.

1990 • 80 citations

Pharmacologic interactions between the resistance‐modifying cyclosporine sdz psc 833 and etoposide (VP 16–213) enhance In Vivo cytostatic activity and toxicity

1992 • 80 citations

Expression of a Human Complementary DNA for the Multidrug Resistance Gene in Murine Hematopoietic Precursor Cells With the Use of Retroviral Gene Transfer

1990 • 80 citations

Advances in Pathology and Laboratory Medicine

1994 • 80 citations

Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts

1989 • 78 citations

Active efflux common to vincristine and daunorubicin in vincristine-resistant P388 leukemia

1981 • 77 citations

Regulation of the multidrug resistance gene in regenerating rat liver.

1990 • 77 citations

A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines.

1988 • 77 citations

Reversal by cefoperazone of resistance to etoposide, doxorubicin, and vinblastine in multidrug resistant human sarcoma cells.

1989 • 74 citations

Implications of the Blood-Brain Barrier and Its Manipulation

1989 • 74 citations

Combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines.

1990 • 73 citations

Verapamil-mediated sensitization of doxorubicin-selected pleiotropic resistance in human sarcoma cells: selectivity for drugs which produce DNA scission.

1986 • 73 citations

Reversal of multidrug resistance by lipophilic drugs.

1990 • 73 citations

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.

1987 • 72 citations

Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein.

1990 • 72 citations

Quantitative Polymerase Chain-Reaction Analysis of mdr1 mRNA in Multiple Myeloma Cell Lines and Clinical Specimens

1993 • 71 citations

Lysosomotropic agents reverse multiple drug resistance in human cancer cells

1986 • 70 citations

Overexpression of multidrug resistance‐associated p170‐glycoprotein in acute non‐lymphocytic leukemia

1992 • 70 citations

Continued expression of vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase.

1982 • 68 citations

Molecular and Clinical Advances in Anticancer Drug Resistance

1991 • 66 citations

A pilot study of quinidine and epirubicin in the treatment of advanced breast cancer

1990 • 66 citations

Circumvention of resistance to daunorubicin by N-acetyldaunorubicin in Ehrlich ascites tumor.

1980 • 66 citations

Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression

1991 • 66 citations

Expression of hamster P-glycoprotein and multidrug resistance in DNA-mediated transformants of mouse LTA cells.

1987 • 63 citations

Drug and Hormone Resistance in Neoplasia

2019 • 63 citations

Deletion and Insertion Mutants of the Multidrug Transporter

1989 • 63 citations

Differential effect of the calmodulin inhibitor trifluoperazine on cellular accumulation, retention, and cytotoxicity of anthracyclines in doxorubicin (adriamycin)-resistant P388 mouse leukemia cells.

1984 • 63 citations

Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone.

1988 • 62 citations

Multidrug Resistance: P-glycoprotein and Its Allies--The Elusive Foes

1989 • 61 citations

HT1080/DR4: A P-Glycoprotein-Negative Human Fibrosarcoma Cell Line Exhibiting Resistance to Topoisomerase II-Reactive Drugs Despite the Presence of a Drug-Sensitive Topoisomerase II

1990 • 60 citations

Structural and functional analysis of the mouse mdr1b gene promoter

1991 • 59 citations

Multidrug resistance genes, p-glycoprotein and the liver

1990 • 57 citations

Dimerization of the P-glycoprotein in membranes

1990 • 57 citations

Verapamil Reversal of Clinical Doxorubicin Resistance in Human Cancer A Wilshire Oncology Medical Group Pilot Phase I-II Study

1986 • 56 citations

P-glycoprotein expression in human breast cancer cells.

1987 • 55 citations

Further Observations on the Effects of Cancer Chemotherapeutic Agents on the <italic>in Vitro</italic> Dehydrogenase Activity of Cancer Tissue<xref ref-type="fn" rid="fn1">2</xref>

1954 • 55 citations

The Clinical Relevance of Multidrug Resistance

1990 • 55 citations

Terfenadine (seldane®): A new drug for restoring sensitivity to multidrug resistant cancer cells

1993 • 53 citations

Expression of the multiple drug resistance gene (mdr‐1) and epitope masking in chronic lymphatic leukaemia

1990 • 53 citations

High expression of the multidrug resistance P-glycoprotein in high-risk myelodysplasia is associated with immature phenotype.

1993 • 53 citations

Immunohistochemical detection of P‐glycoprotein in human tumor cells with a low degree of drug resistance

1989 • 53 citations

Activity of P-Glycoprotein in B-Cell Chronic Lymphocytic Leukemia Determined by a Flow Cytometric Assay

1993 • 52 citations

P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma.

1992 • 52 citations

Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro.

1990 • 52 citations

Decreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA.

1987 • 51 citations

Enhancement of anthracycline growth inhibition in parent and multidrug-resistant Chinese hamster ovary cells by cyclosporin A and its analogues.

1989 • 50 citations

Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.

1992 • 49 citations

Identification and characterization of a plasma membrane phosphoprotein which is present in chinese hamster lung cells resistant to adriamycin

1983 • 49 citations

Modulation of induced resistance to adriamycin in two human breast cancer cell lines with tamoxifen or perhexiline maleate

1988 • 49 citations

SDZ 280-446, a novel semi-synthetic cyclopeptolide: in vitro and in vivo circumvention of the P-glycoprotein-mediated tumour cell multidrug resistance

1992 • 48 citations

The human multidrug resistance gene: sequences upstream and downstream of the initiation site influence transcription.

1990 • 48 citations

Structural Determinants of Phenoxazine Type Compounds Required to Modulate the Accumulation of Vinblastine and Vincristine in Multidrug-Resistant Cell Lines

1990 • 47 citations

Modulators of P-glycoprotein-associated multidrug resistance

1991 • 47 citations

Expression of a Multidrug Resistance Gene in Esophageal Adenocarcinoma: Correlation with Response to Chemotherapy and Comparison with Gastric Adenocarcinoma

1990 • 46 citations

Is the mdr 1 gene relevant in chronic lymphocytic leukemia

1990 • 45 citations

Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells

1992 • 45 citations

Expression of a Multidrug Resistance Gene in Blast Crisis of Chronic Myelogenous Leukemia

1989 • 44 citations

Structural and Functional Analyses of the Promoter of the Murine Multidrug Resistance Genemdr3/mdrlaReveal a Negative Element Containing the AP-1 Binding Site

1991 • 44 citations

The tissue dependent expression of hamster P‐glycoprotein genes

1988 • 42 citations

Expression of the mdr (P-glycoprotein) Gene in Chinese Hamster Digestive Tracts1

1988 • 42 citations

Structure-activity study and design of multidrug-resistant reversal compounds by a computer automated structure evaluation methodology.

1992 • 41 citations

Potentiation of Some Anticancer Agents by Dipyridamole against Drug‐sensitive and Drug‐resistant Cancer Cell Lines

1989 • 41 citations

Characteristics of Multidrug Resistance in Human Tumor Cells

1991 • 40 citations

Effects of verapamil on the pharmacokinetics of daunomycin in the rat

1987 • 36 citations

ATP and GTP as alternative energy sources for vinblastine transport by P‐170 in KB‐V1 plasma membrane vesicles

1992 • 36 citations

Mitomycin C resistant L1210 leukemia cells: Association with pleiotropic drug resistance

1987 • 36 citations

An in vivo model of human multidrug-resistant multiple myeloma in SCID mice.

1993 • 35 citations

Amiodarone is more efficient than verapamil in reversing resistance to anthracyclines in tumour cells

1987 • 34 citations

Treatment of refractory multiple myeloma and considerations for future therapy.

1986 • 32 citations

Development and characterization of a human myelogenous leukemia cell line resistant to 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide.

1987 • 32 citations

Differential effect of the calmodulin inhibitor trifluoperazine in modulating cellular accumulation, retention and cytotoxicity of doxorubicin in progressively doxorubicin-resistant L1210 mouse leukemia cells

1988 • 31 citations

The multidrug resistance phenotype in human cancer.

1991 • 31 citations

Multidrug resistance gene expression in pediatric primitive neuroectodermal tumors of the central nervous system

1992 • 30 citations

Is the mdr 1 gene relevant in chronic lymphocytic leukemia?

1990 • 29 citations

Adequate tumour quinidine levels for multidrug resistance modulation can be achieved in vivo

1992 • 29 citations

Reduced mRNA levels for the multidrug‐resistance genes in cAMP‐dependent protein kinase mutant cell lines

1992 • 29 citations

In situ hybridization analysis of acquisition and loss of the human multidrug-resistance gene.

1988 • 28 citations

Activity of Cyclosporin A and a Non-Immunosuppressive Cyclosporin Against Multidrug Resistant Leukemic Cell Lines

1989 • 27 citations

DNA Cross-linking and Cytotoxicity of the Alkylating Cyanomorpholino Derivative of Doxorubicin in Multidrug-Resistant Cells2

1988 • 27 citations

Rapid Functional Assay for Multidrug Resistance in Human Tumor Cell Lines Using the Fluorescent Indicator Fluo-3

1991 • 25 citations

Pseudomonas Exotoxin Conjugated to Monoclonal Antibody MRK16 Specifically Kills Multidrug Resistant Cells in Cultured Renal Carcinomas and In Mdr-Transgenic Mice

1993 • 24 citations

Mdr1P-glycoprotein expression in natural killer (NK) cells enriched from peripheral or umbilical cord blood

1993 • 23 citations

PCR-determined expression of the MDR1 gene in chronic lymphocytic leukemia

1992 • 22 citations

Reversal of etoposide resistance in non-P-glycoprotein expressing multidrug resistant tumor cell lines by novobiocin.

1993 • 22 citations

Expression of a multidrug-resistance gene in human malignant lymphoma and related disorders

1991 • 22 citations

Comparison of western blot analysis and immunocytochemical detection of P-glycoprotein in multidrug resistant cells.

1989 • 21 citations

Immunohistochemical detection of the multi-drug-resistance marker P-glycoprotein in uterine cervical carcinomas and normal cervical tissue

1992 • 20 citations

P-glycoprotein expression in locally advanced breast cancer treated by neoadjuvant chemotherapy

1992 • 19 citations

Non-antitumor vinca alkaloids reverse multidrug resistance in P388 leukemia cells in vitro.

1986 • 18 citations

The effects of verapamil and a tiapamil analogue, DMDP, on adriamycin-induced cytotoxicity in P388 adriamycin-resistant and-sensitive leukemia in vitro and in vivo

1988 • 18 citations

Topoisomerase II activity involved in cleaving DNA into topological domains is altered in a multiple drug-resistant Chinese hamster ovary cell line.

1993 • 17 citations

Molecular and Cytogenetic Analysis of Multidrug Resistance-Associated Gene Amplification in Chinese Hamster, Mouse Sarcoma, and Human Neuroblastoma Cells

1991 • 15 citations

Circumvention of drug resistance with calcium channel blockers and monoclonal antibodies

1989 • 14 citations

Molecular diagnosis of multidrug resistance

1994 • 14 citations

Structure and Evolution of P-Glycoproteins

1991 • 12 citations

Structural and functional characterization of the mouse multidrug resistance gene family.

1990 • 11 citations

Cloning and Characterization of Mouse mdr Genes

1991 • 10 citations

Detection of the 170 kDa P-Glycoprotein in Neoplastic and Normal Tissues

1989 • 10 citations

P-glycoprotein gene amplification or overexpression is not detected in clinical breast cancer specimens.

1988 • 7 citations

Chemosensitisation of a drug-sensitive parental cell line by low-dose cyclosporin A

1991 • 3 citations

An in vivo model of chemosensitization of multidrug resistant human myeloma cell line in SCID mice

1994 • 3 citations