SDZ PSC 833, A non‐immunosuppressive cyclosporine: Its potency in overcoming P‐glycoprotein‐mediated multidrug resistance of murine leukemia

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

GLUTATHIONE S-TRANSFERASES: GENE STRUCTURE, REGULATION, AND BIOLOGICAL FUNCTION

1989 • 624 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance

1988 • 301 citations

Multidrug Resistance in Cancer

1989 • 258 citations

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein.

1989 • 242 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Expression of mdr1 and mdr3 Multidrug-resistance Genes in Human Acute and Chronic Leukemias and Association With Stimulation of Drug Accumulation by Cyclosporine

1990 • 210 citations

Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma

1986 • 147 citations

The effect of verapamil on the pharmacokinetics of adriamycin

1986 • 146 citations

Modification of cytotoxic drug resistance by non-immuno-suppressive cyclosporins

1988 • 125 citations

SDZ PSC 833, a non-immunosuppressive cyclosporin analog, is a very potent multidrug-resistance modifier

1991 • 87 citations

Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.

1990 • 87 citations

Overcoming multidrug resistance in Chinese hamster ovary cells in vitro by cyclosporin A (Sandimmune) and non-immunosuppressive derivatives

1989 • 66 citations

What determines the substrate specificity of the multi-drug-resistance pump?

1990 • 61 citations

Effect of cyclosporin A on daunorubicin accumulation in multidrug-resistant P388 leukemia cells measured by real-time flow cytometry

1989 • 60 citations

In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52.

1989 • 54 citations

Comparison of the synergistic potentiation of etoposide, doxorubicin, and vinblastine cytotoxicity by dipyridamole.

1989 • 53 citations

Effects of verapamil on the pharmacokinetics of daunomycin in the rat

1987 • 36 citations

Karnofsky memorial lecture. The oncologic end game.

1986 • 35 citations

Heavy water enhances the antineoplastic effect of 5‐fluoro‐uracil and bleomycin in nude mice bearing human carcinoma

1990 • 15 citations

[An experimental study on subrenal capsule assay (SRCA)--problems for the use of immunosuppressive agents].

1989 • 2 citations