Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Localization of mitochondria in living cells with rhodamine 123.

1980 • 1,529 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Long-term culture of human bone marrow cells.

1980 • 624 citations

Antigen CD34+ marrow cells engraft lethally irradiated baboons.

1988 • 608 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Engraftment after infusion of CD34+ marrow cells in patients with breast cancer or neuroblastoma

1991 • 538 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties.

1989 • 453 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

Monoclonal antibody 12-8 recognizes a 115-kd molecule present on both unipotent and multipotent hematopoietic colony-forming cells and their precursors

1986 • 371 citations

Resting and activated subsets of mouse multipotent hematopoietic stem cells.

1990 • 333 citations

Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells

1990 • 300 citations

Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

1991 • 281 citations

Use of fluorescent dyes as molecular probes for the study of multidrug resistance

1988 • 249 citations

"Pure" Human Hematopoietic Progenitors: Permissive Action of Basic Fibroblast Growth Factor

1990 • 248 citations

Antigenic analysis of hematopoiesis. VI. Flow cytometric characterization of My-10-positive progenitor cells in normal human bone marrow.

1987 • 226 citations

Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro.

1988 • 213 citations

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.

1991 • 212 citations

Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell.

1989 • 209 citations

Multiparameter analysis of transplantable hemopoietic stem cells: I. The separation and enrichment of stem cells homing to marrow and spleen on the basis of rhodamine-123 fluorescence.

1985 • 203 citations

Prognostic importance of immunophenotyping in adults with acute myelocytic leukaemia: the significance of the stem‐cell glycoprotein CD34 (My 10)

1990 • 190 citations

Antigenic analysis of hematopoiesis. V. Characterization of My-10 antigen expression by normal lymphohematopoietic progenitor cells.

1986 • 181 citations

Coinduction of MDR-1 Multidrug-Resistance and Cytochrome P-450 Genes in Rat Liver by Xenobiotics

1988 • 174 citations

Hoechst 33342 dye uptake as a probe of membrane permeability changes in mammalian cells.

1981 • 152 citations

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals

1988 • 125 citations

Genetic basis of multidrug resistance of tumor cells

1990 • 124 citations

The L4F3 antigen is expressed by unipotent and multipotent colony- forming cells but not by their precursors

1986 • 119 citations

Separation and functional analysis of bone marrow cells separated by rhodamine-123 fluorescence.

1987 • 105 citations

Purification of pluripotent hemopoietic stem cells: past and present.

1990 • 102 citations

Cells with marrow and spleen repopulating ability and forming spleen colonies on day 16, 12, and 8 are sequentially ordered on the basis of increasing rhodamine 123 retention

1988 • 101 citations

Multidrug-resistance phenotype of a subpopulation of T-lymphocytes without drug selection

1989 • 101 citations

Reversal of resistance to rhodamine 123 in adriamycin-resistant Friend leukemia cells.

1985 • 69 citations

Marrow repopulating cells, but not CFU-S, establish long-term in vitro hemopoiesis on a marrow-derived stromal layer.

1990 • 58 citations

Two pyridine analogues with more effective ability to reverse multidrug resistance and with lower calcium channel blocking activity than their dihydropyridine counterparts.

1990 • 49 citations

Simultaneous use of Rhodamine 123, phycoerythrin, Texas red, and allophycocyanin for the isolation of human hematopoietic progenitor cells

1991 • 45 citations

Expression of a Multidrug Resistance Gene in Blast Crisis of Chronic Myelogenous Leukemia

1989 • 44 citations

Enrichment of murine hemopoietic clonogenic cells by multivariate analyses and sorting.

1985 • 35 citations

Further enrichment and analysis of rat CFU‐s

1990 • 7 citations

Detection of a Human Hematopoietic Progenitor Cell Capable of Forming Blast Cell Containing Colonies In Vitro

1988 • 5 citations